BibTex RIS Kaynak Göster

Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women

Yıl 2012, Cilt: 6 Sayı: 1, 13 - 20, 01.02.2012

Öz

Estrogen receptor alpha (ER-α) belong to the nuclear receptor superfamily of ligand-inducible transcription factors. It is involve in both mammary development and in breast carcinogenesis. Many polymorphisms suggested association with the incidence of breast cancer. The most widely studied Polymorphisms are PvuII and XbaI restriction sites, they lies within intron one of estrogen receptor alpha gene. This study was done to evaluate the relationship of two well- studied polymorphisms in the estrogen receptor alpha gene, (PvuII and XbaI), and the risk of breast cancer in Jordanian women. In our study, 100 blood samples from Jordanian women with breast cancer had been obtained and used for subsequent DNA extraction and genotyped for the PvuII and XbaI polymorphisms using Restriction Fragment Length Polymorphism (RFLPs) technique. Also, a 100 blood samples from normal Jordanian women had been used as control. For statistical analysis, SPSS computerized program to calculate P-value for polymorphisms and Hardy-Weinberg equation for genotype frequencies was used. There was no significant difference between breast cancer patients and healthy control individuals in the distribution of the PvuII genotypes. There was no significant difference between breast cancer patients and healthy control individuals in the distribution of the PvuII genotypes (P>0.05;P=0.27), no association between XbaI polymorphism and breast cancer risk (P>0.05;P=0.111). Also there was no significant association with haplotype analysis (P>0.05;P=0.07) except for AGTC haplotype (P≤0.05;P=0.043) and AATC haplotype (P≤0.05;P=0.027). This result suggests that PvuII and XbaI polymorphism doesn’t play a role in the susceptibility to breast cancer in Jordanian women

Yıl 2012, Cilt: 6 Sayı: 1, 13 - 20, 01.02.2012

Öz

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Ayrıntılar

Diğer ID JA64FA62CY
Bölüm Dergi Bilgisi
Yazarlar

Fawzi Alsheyab Bu kişi benim

Anas Dannoun Bu kişi benim

Dalal Awad Bu kişi benim

Yousef Mosameh Bu kişi benim

Yayımlanma Tarihi 1 Şubat 2012
Yayımlandığı Sayı Yıl 2012 Cilt: 6 Sayı: 1

Kaynak Göster

APA Alsheyab, F., Dannoun, A., Awad, D., Mosameh, Y. (2012). Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women. Journal of Applied Biological Sciences, 6(1), 13-20.
AMA Alsheyab F, Dannoun A, Awad D, Mosameh Y. Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women. J.appl.biol.sci. Şubat 2012;6(1):13-20.
Chicago Alsheyab, Fawzi, Anas Dannoun, Dalal Awad, ve Yousef Mosameh. “Association Between Estrogen Receptor Alpha Polymorphisms and Breast Cancer Risk in Jordanian Women”. Journal of Applied Biological Sciences 6, sy. 1 (Şubat 2012): 13-20.
EndNote Alsheyab F, Dannoun A, Awad D, Mosameh Y (01 Şubat 2012) Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women. Journal of Applied Biological Sciences 6 1 13–20.
IEEE F. Alsheyab, A. Dannoun, D. Awad, ve Y. Mosameh, “Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women”, J.appl.biol.sci., c. 6, sy. 1, ss. 13–20, 2012.
ISNAD Alsheyab, Fawzi vd. “Association Between Estrogen Receptor Alpha Polymorphisms and Breast Cancer Risk in Jordanian Women”. Journal of Applied Biological Sciences 6/1 (Şubat 2012), 13-20.
JAMA Alsheyab F, Dannoun A, Awad D, Mosameh Y. Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women. J.appl.biol.sci. 2012;6:13–20.
MLA Alsheyab, Fawzi vd. “Association Between Estrogen Receptor Alpha Polymorphisms and Breast Cancer Risk in Jordanian Women”. Journal of Applied Biological Sciences, c. 6, sy. 1, 2012, ss. 13-20.
Vancouver Alsheyab F, Dannoun A, Awad D, Mosameh Y. Association between Estrogen Receptor alpha Polymorphisms and Breast Cancer Risk in Jordanian Women. J.appl.biol.sci. 2012;6(1):13-20.