Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma?

Hüseyin Salih Semiz; Merve Keskinkılıç; Zülal Arıcı; Ferahnaz Badem; Behzat Can; Muzaffer Sancı

doi:10.30621/jbachs.1167095

EN

Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma?

Abstract

Background and Purpose: Optimal cytoreduction (CRS) is the main treatment modality in epithelial ovarian cancer (OC). Inoperable OC at the time of diagnosis may become eligible for CRS after neoadjuvant chemotherapy (NACT). We aimed to investigate the effect of the time between NACT-CRS and CRS-adjuvant chemotherapy on survival in OC patients. Materials and Methods: Demographic and clinicopathological characteristics of sixty-nine patients with OC who underwent CRS after NACT between December 2009 and May 2020 were analyzed retrospectively. Results: The median age was 61.1, and the median overall survival (OS) was 75.8 months. The median time from the end of NACT to CRS was 6.53 weeks, and the median time from CRS to initiation of adjuvant therapy was 4.8 weeks. The mean OS was 123.4 months in patients with a NACT-CRS interval of 6.53 weeks or less, and it was 61.6 months in patients above this period (p>0.05). The OS was 75.7 months in patients with an interval between CRS and adjuvant therapy of 4.8 weeks or less and 55.1 months compared to those with 4.8 weeks or more (p>0.05). Conclusion: It was shown numerically, although not statistically significant, that a long time between NACT and CRS and CRS-adjuvant therapy had a negative effect on OS.

Keywords

Supporting Institution

Bulunmuyor

Project Number

Yok

References

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Details

Primary Language

English

Subjects

Health Care Administration

Journal Section

Research Article

Authors

Hüseyin Salih Semiz ^*
0000-0002-7083-8517
Türkiye

Merve Keskinkılıç
0000-0002-3342-3144
Türkiye

Zülal Arıcı
0000-0003-3844-9455
Türkiye

Ferahnaz Badem
0000-0002-0193-2251
Türkiye

Behzat Can
0000-0002-3797-8227
Türkiye

Muzaffer Sancı
0000-0002-8494-4302
Türkiye

Publication Date

September 29, 2022

Submission Date

August 26, 2022

Acceptance Date

September 5, 2022

Published in Issue

Year 2022 Volume: 6 Number: 3

DOI

https://doi.org/10.30621/jbachs.1167095

IZ

https://izlik.org/JA35SZ22CY

Cite

RIS / Bibtex

APA

Semiz, H. S., Keskinkılıç, M., Arıcı, Z., Badem, F., Can, B., & Sancı, M. (2022). Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma? Journal of Basic and Clinical Health Sciences, 6(3), 877-883. https://doi.org/10.30621/jbachs.1167095

AMA

1.Semiz HS, Keskinkılıç M, Arıcı Z, Badem F, Can B, Sancı M. Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma? JBACHS. 2022;6(3):877-883. doi:10.30621/jbachs.1167095

Chicago

Semiz, Hüseyin Salih, Merve Keskinkılıç, Zülal Arıcı, Ferahnaz Badem, Behzat Can, and Muzaffer Sancı. 2022. “Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma?”. Journal of Basic and Clinical Health Sciences 6 (3): 877-83. https://doi.org/10.30621/jbachs.1167095.

EndNote

Semiz HS, Keskinkılıç M, Arıcı Z, Badem F, Can B, Sancı M (September 1, 2022) Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma? Journal of Basic and Clinical Health Sciences 6 3 877–883.

IEEE

[1]H. S. Semiz, M. Keskinkılıç, Z. Arıcı, F. Badem, B. Can, and M. Sancı, “Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma?”, JBACHS, vol. 6, no. 3, pp. 877–883, Sept. 2022, doi: 10.30621/jbachs.1167095.

ISNAD

Semiz, Hüseyin Salih - Keskinkılıç, Merve - Arıcı, Zülal - Badem, Ferahnaz - Can, Behzat - Sancı, Muzaffer. “Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma?”. Journal of Basic and Clinical Health Sciences 6/3 (September 1, 2022): 877-883. https://doi.org/10.30621/jbachs.1167095.

JAMA

1.Semiz HS, Keskinkılıç M, Arıcı Z, Badem F, Can B, Sancı M. Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma? JBACHS. 2022;6:877–883.

MLA

Semiz, Hüseyin Salih, et al. “Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma?”. Journal of Basic and Clinical Health Sciences, vol. 6, no. 3, Sept. 2022, pp. 877-83, doi:10.30621/jbachs.1167095.

Vancouver

1.Hüseyin Salih Semiz, Merve Keskinkılıç, Zülal Arıcı, Ferahnaz Badem, Behzat Can, Muzaffer Sancı. Does Timing of Treatment Have an Effect on Survival in Ovarian Carcinoma? JBACHS. 2022 Sep. 1;6(3):877-83. doi:10.30621/jbachs.1167095