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Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients

Year 2023, , 471 - 478, 31.01.2023

Emine Acar , Ayşegül Aksu , Ender Berat Ellidokuz , Yasemin Başbınar , Gamze Çapa Kaya

https://doi.org/10.30621/jbachs.1189713

Abstract

The aim of this study; evaluation of treatment response and survival with post-therapy images in patients who received one cycle of Lu-177 PSMA I&T treatment.

Keywords

prostate cancer Lu-177 PSMA radioligand therapy scintigraphy

References

  • 1. Kind F, Fassbender TF, Andrieux G, Boerries M, Meyer PT, Ruf J. Early PSA Change after [(177)Lu]PSMA-617 Radioligand Therapy as a Predicator of Biochemical Response and Overall Survival. Cancers (Basel). 2021;14(1).
  • 2. Gupta M, Karthikeyan G, Choudhury PS, Sharma A, Singh A, Rawal S. Is (177)Lu-PSMA an effective treatment modality for mCRPC patients with bone and visceral metastasis? Hell J Nucl Med. 2020;23(3):312-20.
  • 3. Baumann R, Koncz M, Luetzen U, Krause F, Dunst J. Oligometastases in prostate cancer : Metabolic response in follow-up PSMA-PET-CTs after hypofractionated IGRT. Strahlenther Onkol. 2018;194(4):318-24.
  • 4. Asif S, Teply BA. Biomarkers for Treatment Response in Advanced Prostate Cancer. Cancers (Basel). 2021;13(22).
  • 5. Donin NM, Reiter RE. Why Targeting PSMA Is a Game Changer in the Management of Prostate Cancer. J Nucl Med. 2018;59(2):177-82.
  • 6. Sartor O, de Bono J, Chi KN, et al. Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. N Engl J Med. 2021;385(12):1091-103.
  • 7. Khreish F, Ghazal Z, Marlowe RJ, et al. 177 Lu-PSMA-617 radioligand therapy of metastatic castration-resistant prostate cancer: Initial 254-patient results from a prospective registry (REALITY Study). Eur J Nucl Med Mol Imaging. 2022;49(3):1075-85.
  • 8. Virgolini I, Decristoforo C, Haug A, Fanti S, Uprimny C. Current status of theranostics in prostate cancer. Eur J Nucl Med Mol Imaging. 2018;45(3):471-95.
  • 9. Nioche C, Orlhac F, Boughdad S, et al. LIFEx: A Freeware for Radiomic Feature Calculation in Multimodality Imaging to Accelerate Advances in the Characterization of Tumor Heterogeneity. Cancer Res. 2018;78(16):4786-9.
  • 10. Hall M, Frank E, Holmes G, Pfahringer B, Reutemann P, Witten IH. The WEKA data mining software: an update. SIGKDD Explor Newsl. 2009;11(1):10-8.
  • 11. Dorff TB, Fanti S, Farolfi A, Reiter RE, Sadun TY, Sartor O. The Evolving Role of Prostate-Specific Membrane Antigen-Based Diagnostics and Therapeutics in Prostate Cancer. Am Soc Clin Oncol Educ Book. 2019;39:321-30.
  • 12. Kletting P, Thieme A, Eberhardt N, et al. Modeling and Predicting Tumor Response in Radioligand Therapy. J Nucl Med. 2019;60(1):65-70.
  • 13. Grubmüller B, Senn D, Kramer G, et al. Response assessment using (68)Ga-PSMA ligand PET in patients undergoing (177)Lu-PSMA radioligand therapy for metastatic castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2019;46(5):1063-72.
  • 14. Liu C, Liu T, Zhang N, et al. (68)Ga-PSMA-617 PET/CT: a promising new technique for predicting risk stratification and metastatic risk of prostate cancer patients. Eur J Nucl Med Mol Imaging. 2018;45(11):1852-61.
  • 15. Michalski K, Klein C, Brueggemann T, Meyer PT, Jilg CA, Ruf J. Assessing Response to [(177)Lu]PSMA Radioligand Therapy using modified PSMA PET Progression Criteria. J Nucl Med. 2021;62(12):1741-6.
  • 16. Prasad V, Huang K, Prasad S, Makowski MR, Czech N, Brenner W. In Comparison to PSA, Interim Ga-68-PSMA PET/CT Response Evaluation Based on Modified RECIST 1.1 After 2(nd) Cycle Is Better Predictor of Overall Survival of Prostate Cancer Patients Treated With (177)Lu-PSMA. Front Oncol. 2021;11:578093.
  • 17. Rasul S, Hacker M, Kretschmer-Chott E, et al. Clinical outcome of standardized (177)Lu-PSMA-617 therapy in metastatic prostate cancer patients receiving 7400 MBq every 4 weeks. Eur J Nucl Med Mol Imaging. 2020;47(3):713-20.
  • 18. Zacherl MJ, Gildehaus FJ, Mittlmeier L, et al. First Clinical Results for PSMA-Targeted α-Therapy Using (225)Ac-PSMA-I&T in Advanced-mCRPC Patients. J Nucl Med. 2021;62(5):669-74.
  • 19. Rathke H, Giesel FL, Flechsig P, et al. Repeated (177)Lu-Labeled PSMA-617 Radioligand Therapy Using Treatment Activities of Up to 9.3 GBq. J Nucl Med. 2018;59(3):459-65.
  • 20. Han S, Woo S, Kim YI, et al. Concordance between Response Assessment Using Prostate-Specific Membrane Antigen PET and Serum Prostate-Specific Antigen Levels after Systemic Treatment in Patients with Metastatic Castration Resistant Prostate Cancer: A Systematic Review and Meta-Analysis. Diagnostics (Basel). 2021;11(4).
  • 21. Rathke H, Holland-Letz T, Mier W, et al. Response Prediction of (177)Lu-PSMA-617 Radioligand Therapy Using Prostate-Specific Antigen, Chromogranin A, and Lactate Dehydrogenase. J Nucl Med. 2020;61(5):689-95.
  • 22. Sadaghiani MS, Sheikhbahaei S, Werner RA, et al. (177) Lu-PSMA radioligand therapy effectiveness in metastatic castration-resistant prostate cancer: An updated systematic review and meta-analysis. Prostate. 2022;82(7):826-35.
  • 23. Sun M, Niaz MO, Nelson A, Skafida M, Niaz MJ. Review of 177Lu-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer. Cureus. 2020;12(6):e8921.
  • 24. Jackson PA, Hofman MS, Hicks RJ, Scalzo M, Violet J. Radiation Dosimetry in (177)Lu-PSMA-617 Therapy Using a Single Posttreatment SPECT/CT Scan: A Novel Methodology to Generate Time- and Tissue-Specific Dose Factors. J Nucl Med. 2020;61(7):1030-6.
  • 25. Maffey-Steffan J, Scarpa L, Svirydenka A, et al. The (68)Ga/(177)Lu-theragnostic concept in PSMA-targeting of metastatic castration-resistant prostate cancer: impact of post-therapeutic whole-body scintigraphy in the follow-up. Eur J Nucl Med Mol Imaging. 2020;47(3):695-712.
  • 26. Yordanova A, Linden P, Hauser S, et al. Outcome and safety of rechallenge [(177)Lu]Lu-PSMA-617 in patients with metastatic prostate cancer. Eur J Nucl Med Mol Imaging. 2019;46(5):1073-80.
  • 27. Kelk E, Ruuge P, Rohtla K, Poksi A, Kairemo K. Radiomics Analysis for (177)Lu-DOTAGA-(l-y)fk(Sub-KuE) Targeted Radioligand Therapy Dosimetry in Metastatic Prostate Cancer-A Model Based on Clinical Example. Life (Basel). 2021;11(2).
  • 28. Manafi-Farid R, Harsini S, Saidi B, et al. Factors predicting biochemical response and survival benefits following radioligand therapy with [(177)Lu]Lu-PSMA in metastatic castrate-resistant prostate cancer: a review. Eur J Nucl Med Mol Imaging. 2021;48(12):4028-41.
  • 29. O'Dwyer E, Bodei L, Morris MJ. The Role of Theranostics in Prostate Cancer. Semin Radiat Oncol. 2021;31(1):71-82.
  • 30. Sorace AG, Elkassem AA, Galgano SJ, et al. Imaging for Response Assessment in Cancer Clinical Trials. Semin Nucl Med. 2020;50(6):488-504.

Year 2023, , 471 - 478, 31.01.2023

Emine Acar , Ayşegül Aksu , Ender Berat Ellidokuz , Yasemin Başbınar , Gamze Çapa Kaya

https://doi.org/10.30621/jbachs.1189713

Abstract

References

  • 1. Kind F, Fassbender TF, Andrieux G, Boerries M, Meyer PT, Ruf J. Early PSA Change after [(177)Lu]PSMA-617 Radioligand Therapy as a Predicator of Biochemical Response and Overall Survival. Cancers (Basel). 2021;14(1).
  • 2. Gupta M, Karthikeyan G, Choudhury PS, Sharma A, Singh A, Rawal S. Is (177)Lu-PSMA an effective treatment modality for mCRPC patients with bone and visceral metastasis? Hell J Nucl Med. 2020;23(3):312-20.
  • 3. Baumann R, Koncz M, Luetzen U, Krause F, Dunst J. Oligometastases in prostate cancer : Metabolic response in follow-up PSMA-PET-CTs after hypofractionated IGRT. Strahlenther Onkol. 2018;194(4):318-24.
  • 4. Asif S, Teply BA. Biomarkers for Treatment Response in Advanced Prostate Cancer. Cancers (Basel). 2021;13(22).
  • 5. Donin NM, Reiter RE. Why Targeting PSMA Is a Game Changer in the Management of Prostate Cancer. J Nucl Med. 2018;59(2):177-82.
  • 6. Sartor O, de Bono J, Chi KN, et al. Lutetium-177-PSMA-617 for Metastatic Castration-Resistant Prostate Cancer. N Engl J Med. 2021;385(12):1091-103.
  • 7. Khreish F, Ghazal Z, Marlowe RJ, et al. 177 Lu-PSMA-617 radioligand therapy of metastatic castration-resistant prostate cancer: Initial 254-patient results from a prospective registry (REALITY Study). Eur J Nucl Med Mol Imaging. 2022;49(3):1075-85.
  • 8. Virgolini I, Decristoforo C, Haug A, Fanti S, Uprimny C. Current status of theranostics in prostate cancer. Eur J Nucl Med Mol Imaging. 2018;45(3):471-95.
  • 9. Nioche C, Orlhac F, Boughdad S, et al. LIFEx: A Freeware for Radiomic Feature Calculation in Multimodality Imaging to Accelerate Advances in the Characterization of Tumor Heterogeneity. Cancer Res. 2018;78(16):4786-9.
  • 10. Hall M, Frank E, Holmes G, Pfahringer B, Reutemann P, Witten IH. The WEKA data mining software: an update. SIGKDD Explor Newsl. 2009;11(1):10-8.
  • 11. Dorff TB, Fanti S, Farolfi A, Reiter RE, Sadun TY, Sartor O. The Evolving Role of Prostate-Specific Membrane Antigen-Based Diagnostics and Therapeutics in Prostate Cancer. Am Soc Clin Oncol Educ Book. 2019;39:321-30.
  • 12. Kletting P, Thieme A, Eberhardt N, et al. Modeling and Predicting Tumor Response in Radioligand Therapy. J Nucl Med. 2019;60(1):65-70.
  • 13. Grubmüller B, Senn D, Kramer G, et al. Response assessment using (68)Ga-PSMA ligand PET in patients undergoing (177)Lu-PSMA radioligand therapy for metastatic castration-resistant prostate cancer. Eur J Nucl Med Mol Imaging. 2019;46(5):1063-72.
  • 14. Liu C, Liu T, Zhang N, et al. (68)Ga-PSMA-617 PET/CT: a promising new technique for predicting risk stratification and metastatic risk of prostate cancer patients. Eur J Nucl Med Mol Imaging. 2018;45(11):1852-61.
  • 15. Michalski K, Klein C, Brueggemann T, Meyer PT, Jilg CA, Ruf J. Assessing Response to [(177)Lu]PSMA Radioligand Therapy using modified PSMA PET Progression Criteria. J Nucl Med. 2021;62(12):1741-6.
  • 16. Prasad V, Huang K, Prasad S, Makowski MR, Czech N, Brenner W. In Comparison to PSA, Interim Ga-68-PSMA PET/CT Response Evaluation Based on Modified RECIST 1.1 After 2(nd) Cycle Is Better Predictor of Overall Survival of Prostate Cancer Patients Treated With (177)Lu-PSMA. Front Oncol. 2021;11:578093.
  • 17. Rasul S, Hacker M, Kretschmer-Chott E, et al. Clinical outcome of standardized (177)Lu-PSMA-617 therapy in metastatic prostate cancer patients receiving 7400 MBq every 4 weeks. Eur J Nucl Med Mol Imaging. 2020;47(3):713-20.
  • 18. Zacherl MJ, Gildehaus FJ, Mittlmeier L, et al. First Clinical Results for PSMA-Targeted α-Therapy Using (225)Ac-PSMA-I&T in Advanced-mCRPC Patients. J Nucl Med. 2021;62(5):669-74.
  • 19. Rathke H, Giesel FL, Flechsig P, et al. Repeated (177)Lu-Labeled PSMA-617 Radioligand Therapy Using Treatment Activities of Up to 9.3 GBq. J Nucl Med. 2018;59(3):459-65.
  • 20. Han S, Woo S, Kim YI, et al. Concordance between Response Assessment Using Prostate-Specific Membrane Antigen PET and Serum Prostate-Specific Antigen Levels after Systemic Treatment in Patients with Metastatic Castration Resistant Prostate Cancer: A Systematic Review and Meta-Analysis. Diagnostics (Basel). 2021;11(4).
  • 21. Rathke H, Holland-Letz T, Mier W, et al. Response Prediction of (177)Lu-PSMA-617 Radioligand Therapy Using Prostate-Specific Antigen, Chromogranin A, and Lactate Dehydrogenase. J Nucl Med. 2020;61(5):689-95.
  • 22. Sadaghiani MS, Sheikhbahaei S, Werner RA, et al. (177) Lu-PSMA radioligand therapy effectiveness in metastatic castration-resistant prostate cancer: An updated systematic review and meta-analysis. Prostate. 2022;82(7):826-35.
  • 23. Sun M, Niaz MO, Nelson A, Skafida M, Niaz MJ. Review of 177Lu-PSMA-617 in Patients With Metastatic Castration-Resistant Prostate Cancer. Cureus. 2020;12(6):e8921.
  • 24. Jackson PA, Hofman MS, Hicks RJ, Scalzo M, Violet J. Radiation Dosimetry in (177)Lu-PSMA-617 Therapy Using a Single Posttreatment SPECT/CT Scan: A Novel Methodology to Generate Time- and Tissue-Specific Dose Factors. J Nucl Med. 2020;61(7):1030-6.
  • 25. Maffey-Steffan J, Scarpa L, Svirydenka A, et al. The (68)Ga/(177)Lu-theragnostic concept in PSMA-targeting of metastatic castration-resistant prostate cancer: impact of post-therapeutic whole-body scintigraphy in the follow-up. Eur J Nucl Med Mol Imaging. 2020;47(3):695-712.
  • 26. Yordanova A, Linden P, Hauser S, et al. Outcome and safety of rechallenge [(177)Lu]Lu-PSMA-617 in patients with metastatic prostate cancer. Eur J Nucl Med Mol Imaging. 2019;46(5):1073-80.
  • 27. Kelk E, Ruuge P, Rohtla K, Poksi A, Kairemo K. Radiomics Analysis for (177)Lu-DOTAGA-(l-y)fk(Sub-KuE) Targeted Radioligand Therapy Dosimetry in Metastatic Prostate Cancer-A Model Based on Clinical Example. Life (Basel). 2021;11(2).
  • 28. Manafi-Farid R, Harsini S, Saidi B, et al. Factors predicting biochemical response and survival benefits following radioligand therapy with [(177)Lu]Lu-PSMA in metastatic castrate-resistant prostate cancer: a review. Eur J Nucl Med Mol Imaging. 2021;48(12):4028-41.
  • 29. O'Dwyer E, Bodei L, Morris MJ. The Role of Theranostics in Prostate Cancer. Semin Radiat Oncol. 2021;31(1):71-82.
  • 30. Sorace AG, Elkassem AA, Galgano SJ, et al. Imaging for Response Assessment in Cancer Clinical Trials. Semin Nucl Med. 2020;50(6):488-504.
There are 30 citations in total.

Details

Primary Language English
Subjects Health Care Administration
Journal Section Research Article
Authors

Emine Acar 0000-0002-6861-8814

Ayşegül Aksu 0000-0002-6239-0660

Ender Berat Ellidokuz 0000-0001-5863-3298

Yasemin Başbınar 0000-0001-9439-2217

Gamze Çapa Kaya 0000-0002-1256-7325

Publication Date January 31, 2023
Submission Date October 18, 2022
Published in Issue Year 2023

Cite

APA Acar, E., Aksu, A., Ellidokuz, E. B., Başbınar, Y., et al. (2023). Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients. Journal of Basic and Clinical Health Sciences, 7(1), 471-478. https://doi.org/10.30621/jbachs.1189713
AMA Acar E, Aksu A, Ellidokuz EB, Başbınar Y, Çapa Kaya G. Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients. JBACHS. January 2023;7(1):471-478. doi:10.30621/jbachs.1189713
Chicago Acar, Emine, Ayşegül Aksu, Ender Berat Ellidokuz, Yasemin Başbınar, and Gamze Çapa Kaya. “Evaluation of Tumor Burden Response to Single-Cycle of Lu-177 PSMA Treatment With Whole Body Scintigraphic Planar Images in Prostate Cancer Patients”. Journal of Basic and Clinical Health Sciences 7, no. 1 (January 2023): 471-78. https://doi.org/10.30621/jbachs.1189713.
EndNote Acar E, Aksu A, Ellidokuz EB, Başbınar Y, Çapa Kaya G (January 1, 2023) Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients. Journal of Basic and Clinical Health Sciences 7 1 471–478.
IEEE E. Acar, A. Aksu, E. B. Ellidokuz, Y. Başbınar, and G. Çapa Kaya, “Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients”, JBACHS, vol. 7, no. 1, pp. 471–478, 2023, doi: 10.30621/jbachs.1189713.
ISNAD Acar, Emine et al. “Evaluation of Tumor Burden Response to Single-Cycle of Lu-177 PSMA Treatment With Whole Body Scintigraphic Planar Images in Prostate Cancer Patients”. Journal of Basic and Clinical Health Sciences 7/1 (January 2023), 471-478. https://doi.org/10.30621/jbachs.1189713.
JAMA Acar E, Aksu A, Ellidokuz EB, Başbınar Y, Çapa Kaya G. Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients. JBACHS. 2023;7:471–478.
MLA Acar, Emine et al. “Evaluation of Tumor Burden Response to Single-Cycle of Lu-177 PSMA Treatment With Whole Body Scintigraphic Planar Images in Prostate Cancer Patients”. Journal of Basic and Clinical Health Sciences, vol. 7, no. 1, 2023, pp. 471-8, doi:10.30621/jbachs.1189713.
Vancouver Acar E, Aksu A, Ellidokuz EB, Başbınar Y, Çapa Kaya G. Evaluation of Tumor Burden Response to Single-cycle of Lu-177 PSMA Treatment with Whole Body Scintigraphic Planar Images in Prostate Cancer Patients. JBACHS. 2023;7(1):471-8.