Effect of Telerehabilitation Based High Intensity Interval Training on Biochemistry Parameters and Symptoms in Patients with Fibromyalgia

Year 2025, Volume: 9 Issue: 1, 151 - 157, 31.01.2025

Selin Akıl Ağdere , Esra Pehlivan , Ezgi Kat , Nazlı Helvacı , Alev Kural , Meltem Vural

https://doi.org/10.30621/jbachs.1535186

Abstract

Effect of Telerehabilitation Based High Intensity Interval Training on Biochemistry Parameters and Symptoms in Patients with Fibromyalgia

Abstract

Purpose: The aim of this study was to evaluate the effect of telerehabilitation-based high intensity interval training (HIIT) on biochemistry parameters and disease symptoms in fibromyalgia patients. Fibromyalgia syndrome (FMS) is a chronic musculoskeletal disease of unknown etiology accompanied by symptoms such as pain, hyperalgesia, sleep disorders, fatigue and mood disorders.

Material and Methods: 33 fibromyalgia patients were randomly assigned as HIIT (n = 11), moderate-intensity continuous training (MICT)(n = 11) and control group (CG)(n = 11). While the patients in the study groups were given upper extremity exercise with telerehabilitation for 6 weeks, no intervention was applied to the CG. Disease symptoms and blood parameters were evaluated before and after treatment.

Results: After the treatment, significant changes were found in the results of superoxide dismutase (SOD), malondialdehyde (MDA), glutathione peroxidase GSH(Px), right hand grip strength, pressure pain threshold, fatigue severity and disability in the HIIT group, and in the results of SOD, myeloperoxidase (MPO), left hand grip strength and fatigue severity in the MICT group (p<0 .05). There was a difference in the results of SOD, right hand grip strength, disability, and fatigue severity between the post-treatment groups due to the HIIT group (p<0.05).

Conclusion: HIIT may be an effective treatment choice for patients.

Keywords

Fibromyalgia , High Intensity Interval Exercise , Telerehabilitation

Ethical Statement

Approval for this study was received from the Clinical Research Ethics Committee of Bakırköy Sadi Konuk Training and Research Hospital.

Supporting Institution

There is a source of support from Health Sciences University BAP Coordination Unit. Project Number: 2022/043. All authors declare that there is no conflict of interest. The study was carried out in Bakirkoy Dr. Sadi Konuk Training and Research Hospital.

References

• Barjandi G, Louca Jounger S, Löfgren M, Bileviciute-Ljungar I, Kosek E, Ernberg M. Plasma tryptophan and kynurenine in females with temporomandibular disorders and fibromyalgia-An exploratory pilot study. J Oral Rehabil 2020;47(2):150-157.
• Jauhar S, Cowen PJ, Browning M. Fifty years on: Serotonin and depression. J Psychopharmacol 2023;37(3):237-241.
• Makrani AH, Afshari M, Ghajar M, Forooghi Z, Moosazadeh M. Vitamin D and fibromyalgia: a meta-analysis. Korean J Pain 2017;30(4):250–257.
• Silva LAD, Tortelli L, Motta J, Menguer L, Mariano S, Tasca G, et al. Effects of aquatic exercise on mental health, functional autonomy and oxidative stress in depressed elderly individuals: A randomized clinical trial. Clinics (Sao Paulo) 2019;74:e322.
• Atan T, Karavelioğlu Y. Effectiveness of High-Intensity Interval Training vs Moderate-Intensity Continuous Training in Patients with Fibromyalgia: A Pilot Randomized Controlled Trial. Arch Phys Med Rehabil 2020;101(11):1865–1876.
• Pinto N, Salassi JW 3rd, Donlin A, Schroeder J, Rozenek R. Effects of a 6-Week Upper Extremity Low-Volume, High-Intensity Interval Training Program on Oxygen Uptake, Peak Power Output, and Total Exercise Time. J Strength Cond Res 2019;33(5):1295–1304.
• Hernando-Garijo I, Ceballos-Laita L, Mingo-Gómez MT, Medrano-de-la-Fuente R, Estébanez-de-Miguel E, Martínez-Pérez MN, et al. Immediate Effects of a Telerehabilitation Program Based on Aerobic Exercise in Women with Fibromyalgia. Int J Environ Res Public Health 2021;18(4): 1–12.
• Ahmed S, Aggarwal A, Lawrence A. Performance of the American College of Rheumatology 2016 criteria for fibromyalgia in a referral care setting. Rheumatol Int 2019 ;39(8):1397-1403.
• Wu YQ, Long Y, Peng WJ, Gong C, Liu YQ, Peng XM et al. The Efficacy and Safety of Telerehabilitation for Fibromyalgia: Systematic Review and Meta-analysis of Randomized Controlled Trials. J Med Internet Res 2023;25;25:e42090.
• Pietta-Dias C, Bello MD, da Silva R, Vargas C, Machado GDB, Roncada C, et al. Differential impact of endurance, strength, or combined training on quality of life and plasma serotonin in healthy older women. Aging Clin Exp Res 2019;31(11):1573-1581.
• de la Coba P, Montoro CI, Reyes Del Paso GA, Galvez-Sánchez CM. Algometry for the assessment of central sensitisation to pain in fibromyalgia patients: a systematic review. Ann Med 2022;54(1):1403-1422.
• Nadal-Nicolás Y, Rubio-Arias JÁ, Martínez-Olcina M, Reche-García C, Hernández-García M, Martínez-Rodríguez A. Effects of Manual Therapy on Fatigue, Pain, and Psychological Aspects in Women with Fibromyalgia. Int J Environ Res Public Health 2020;26;17(12):4611.
• Esteban-Cornejo I, Ho FK, Petermann-Rocha F, Lyall DM, Martinez-Gomez D, Cabanas-Sánchez V, et al. Handgrip strength and all-cause dementia incidence and mortality: findings from the UK Biobank prospective cohort study. J Cachexia Sarcopenia Muscle 2022;13(3):1514-1525.
• Celepkolu T, Gamze Erten Bucaktepe P, Yilmaz A, Pervane VD, Batmaz I, Sariyildiz MA. Assessment of quality of life, anxiety, depression, and sleep quality in women with fibromyalgia and their spouses. Eur Rev Med Pharmacol Sci 2021;25(13):4506-4513.
• Lee M. Clinimetrics: The Revised Fibromyalgia Impact Questionnaire. J Physiother 2021;67(3):220-221.
• Schneider CD, Barp J, Ribeiro JL, Belló-Klein A, Oliveira AR. Oxidative stress after three different intensities of running. Can J Appl Physiol 2005;30(6):723–734.
• Kang H. Sample size determination and power analysis using the G*Power software. J Educ Eval Health Prof 2021;18:1–12.
• Haghshenas R, Jamshidi Z, Doaei S, Gholamalizadeh M. The Effect of a High-intensity Interval Training on Plasma Vitamin D Level in Obese Male Adolescents. Indian J Endocrinol Metab 2019;23(1):72–75.
• Santos JM, Mendonça VA, Ribeiro VGC, Tossige-Gomes R, Fonseca SF, Prates CAN. Does whole body vibration exercise improve oxidative stress markers in women with fibromyalgia? Brazilian J Med Biol Res 2019;52(8).
• Algul S, Ugras S, Kara M. Comparative evaluation of MDA levels during aerobic exercise in young trained and sedentary male subjects. East J Med 2018;23(2), 98–101.
• Assavarittirong C, Samborski W, Grygiel-Górniak B. Oxidative Stress in Fibromyalgia: From Pathology to Treatment. Oxid Med Cell Longev 2022;1582432.
• Jiménez-García JD, Hita-Contreras F, de la Torre-Cruz MJ, Aibar-Almazán A, Achalandabaso-Ochoa A, Fábrega-Cuadros R, Martínez-Amat A. Effects of HIIT and MIIT Suspension Training Programs on Sleep Quality and Fatigue in Older Adults: Randomized Controlled Clinical Trial. Int J Environ Res Public Health 2021;29;18(3):1211.
• Geraghty AWA, Maund E, Newell D, Santer M, Everitt H, Price C, Pincus T, Moore M, Little P, West R, Stuart B. Self-management for chronic widespread pain including fibromyalgia: A systematic review and meta-analysis. PLoS One 2021;16(7):e0254642.