Does The Pregabalin Show Neuroprotection in a Head Injury Rat Model?

Abstract

Does The Pregabalin Show Neuroprotection in a Head Injury Rat Model?

Abstract

Background and Purpose: Traumatic brain injury (TBI) encompasses both primary and secondary injury mechanisms that contribute to its overall pathogenesis. Pregabalin is used in the treatment of neuropathic pain. Treatments targeting excitotoxicity may be useful in the posttraumatic period. Purpose of this study is to examine the possible neuroprotective effects of pregabalin administered in a rat model of head trauma. Methods: 32 male Wistar rats were used. The rats were randomly assigned into four distinct groups, each consisting of eight subjects: a control group, a trauma group, and groups receiving treatment with MPSS and pregabalin. In Brain Samples, assessment of malondialdehyde (MDA), glutathione peroxidase (GPx), and superoxide dismutase (SOD) enzyme activities were evaluated. Results: There was a notable statistical discrepancy in malondialdehyde (MDA) levels when comparing the control group with the others (P<0.05). Both the Pregabalin and MPSS groups exhibited elevated GPx and SOD levels relative to the control group, with the differences being statistically significant (P<0.05). Conclusion: Pregabalin and MPSS protected the brain against traumatic injury by attenuating lipid peroxidation and inflammatory process

Keywords

• Pregabalin
• Rat model
• Head injury
• Antioxidant

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