Trends in National Burden of Incidence and Mortality Rates Attributable to Cervical, Uterine, and Ovarian Cancer from 2008 to 2021 in Türkiye: Findings From the Global Burden of Disease Study

Abstract

Trends in National Burden of Incidence and Mortality Rates Attributable to Cervical, Uterine, and Ovarian Cancer from 2008 to 2021 in Türkiye: Findings From the Global Burden of Disease Study

Abstract

Purpose: Monitoring trends in cervical, uterine, and ovarian cancers is crucial for public health planning. This study aimed to investigate trends in mortality and incidence rates for these cancers in Türkiye between 2008 and 2021 using data from the Global Burden of Disease (GBD) study. Material and Methods: Age-standardized mortality and incidence rates per 100,000 population were obtained from the Global Health Data Exchange (GHDx) platform. Trends were assessed by simple linear regression analysis, estimating annual and cumulative changes over 13 years. Results: Between 2008 and 2021, cervical cancer incidence significantly decreased by 0.039 per 100,000 annually (95% CI: -0.049 to -0.029, p<0.001), totaling a cumulative decline of 0.51 per 100,000. Conversely, uterine cancer incidence significantly increased by 0.249 per 100,000 annually (95% CI: 0.196–0.301, p<0.001), resulting in a cumulative increase of 3.24 per 100,000. Ovarian cancer incidence rose moderately by 0.038 per 100,000 per year (95% CI: 0.022–0.054, p<0.001), with a cumulative increase of 0.49 per 100,000. Mortality from cervical cancer significantly decreased (annual change -0.032 per 100,000; 95% CI: -0.037 to -0.026, p<0.001), while uterine (annual change 0.017 per 100,000; 95% CI: 0.005–0.028, p=0.008) and ovarian (annual change 0.020 per 100,000; 95% CI: 0.008–0.031, p=0.003) cancer mortality rates increased modestly. Conclusion: Türkiye showed decreasing trends in cervical cancer incidence and mortality, likely due to effective screening programs. However, rising incidence rates of uterine and ovarian cancers necessitate intensified public health strategies targeting obesity, early

Keywords

• Cervical cancer
• uterine cancer
• ovarian cancer
• mortality trends
• incidence rates

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