Are There Any Sex-Depended Differences in Water Transporting Proteins of Choroid Plexus in Mice?

Abstract

Background: It is known that sex hormones show modulatory effects on the central nervous system CNS . Various CNS pathologies show sex-related differences in terms of rates, symptoms, and the course of the disease. Some of the functions of choroid plexus CP are under the control of sex hormones. The aim of this descriptive study was to evaluate sex effects on CP water channels. Methods: Expressions of Aquaporin AQP 1, 2 and 4 proteins in CP were compared between in male and female Balb/C mice brains; and also in different stages of the estrous cycle, with immunohistochemistry. Results: No difference is observed for AQP 1, 2 and 4 immunoreactivities in male and female brain, including different stages of the estrous cycle. Conclusion: In conclusion, to the best of our knowledge, AQP2 expression was shown in the CP for the first time, and no sex hormonedependent differences were found in terms of expressions of AQP1, 2 and 4.

Keywords

• choroid plexus, water channels, sex differences, aquaporin 1, aquaporin 2, aquaporin 4

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