A Huge Lesion in the Maxillary Posterior Region Diagnosed High Grade Mucoepidermoid Carcinoma of Minor Salivary Glands: A Case Report

Yıl 2022, Cilt: 6 Sayı: 1, 306 - 313, 27.01.2022

Güldane Mağat Sevgi Özcan Fatma Yüce Mine Çetin Mehmet Esad Güven Fakih Cihat Eravcı Kaan Orhan

https://doi.org/10.30621/jbachs.1017162

Öz

Mucoepidermoid carcinoma (MEC) is the most common malignant tumor of the minor and major salivary glands. These tumors occur commonly in the major salivary glands, especially the parotid, and they are the most frequently located in the palate intraorally. The similarity between MEC and other odontogenic cysts in the mouth is a critical situation that needs attention in clinical examination. Early diagnosis is very important in the diagnosis of asymptomatic growth, reaching very large sizes easily, its recurrence potential, and malignant character. The treatment and prosthetic rehabilitation of MEC are specified according to histopathological grade, location, and invasion pattern of the tumors. The purpose of this case is to present a 19-years-old female with high-grade MEC of minor salivary glands at the palate.

Anahtar Kelimeler

mucoepidermoid, carcinoma, cone-beam computed tomography, diagnostic imaging.

A Huge Lesion in the Maxillary Posterior Region Diagnosed High Grade Mucoepidermoid Carcinoma of Minor Salivary Glands: A Case Report

Öz

Mukoepidermoid karsinom (MEK), minör ve majör tükürük bezlerinin en sık görülen malign tümörüdür. Bu tümörler sıklıkla majör tükürük bezlerinde, özellikle parotis bezinde görülür ve en sık ağız içinde damakta yerleşim gösterirler. Ağızdaki MEK ile diğer odontojenik kistlerin benzerliği klinik muayenede dikkat edilmesi gereken kritik bir durumdur. Asemptomatik büyüme, çok büyük boyutlara kolayca ulaşması, nüks potansiyeli ve malign karakterin tanısında erken teşhis çok önemlidir. MEK'nin tedavisi ve protetik rehabilitasyonu, tümörlerin histopatolojik derecesi, yeri ve invazyon paternine göre belirlenir. Bu vakanın amacı, damakta yüksek dereceli minör tükürük bezi MEK'si olan 19 yaşında bir kadın hastayı sunmaktır.

Anahtar Kelimeler

mukoepidermoid, karsinom, konik ışınlı bilgisayarlı tomografi, tanısal görüntüleme.

Kaynakça

• 1. López-Terrada D, Bloom M, Cagle PT, Ostrowski ML. Oncocytic mucoepidermoid carcinoma of the trachea. Archives of Pathology and Laboratory Medicine. 1999;123(7):635-7.
• 2. Nance MA, Seethala RR, Wang Y, Chiosea SI, Myers EN, Johnson JT, et al. Treatment and survival outcomes based on histologic grading in patients with head and neck mucoepidermoid carcinoma. Cancer. 2008;113(8):2082-9.
• 3. Ellis MA, Graboyes EM, Day TA, Neskey DM. Prognostic factors and occult nodal disease in mucoepidermoid carcinoma of the oral cavity and oropharynx: an analysis of the National Cancer Database. Oral oncology. 2017;72:174-8.
• 4. Peraza A, Gómez R, Beltran J, Amarista FJ. Mucoepidermoid carcinoma. An update and review of the literature. Journal of stomatology, oral and maxillofacial surgery. 2020.
• 5. Schwarz S, Stiegler C, Müller M, Ettl T, Brockhoff G, Zenk J, et al. Salivary gland mucoepidermoid carcinoma is a clinically, morphologically and genetically heterogeneous entity: a clinicopathological study of 40 cases with emphasis on grading, histological variants and presence of the t (11; 19) translocation. Histopathology. 2011;58(4):557-70.
• 6. Brandwein MS, Ivanov K, Wallace DI, Hille JJ, Wang B, Fahmy A, et al. Mucoepidermoid carcinoma: a clinicopathologic study of 80 patients with special reference to histological grading. The American journal of surgical pathology. 2001;25(7):835-45.
• 7. Sultan I, Rodriguez-Galindo C, Al-Sharabati S, Guzzo M, Casanova M, Ferrari A. Salivary gland carcinomas in children and adolescents: a population-based study, with comparison to adult cases. Head Neck. 2011;33(10):1476-81.
• 8. Poletto AG, Mello FW, Melo G, Rivero ERC. Prevalence of mucoepidermoid carcinoma among intraoral minor salivary gland tumors: a systematic review and meta‐analysis. Journal of Oral Pathology & Medicine. 2020.
• 9. Spiro RH, Huvos AG, Berk R, Strong EW. Mucoepidermoid carcinoma of salivary gland origin: a clinicopathologic study of 367 cases. The American Journal of Surgery. 1978;136(4):461-8.
• 10. Li X, Wang F, Wang Y, Sun S, Yang H. An unusual case of intraosseous mucoepidermoid carcinoma of the mandible: A case report and literature review. Medicine. 2018;97(51).
• 11. Russell JL, Chen NW, Ortiz SJ, Schrank TP, Kuo YF, Resto VA. Racial and Ethnic Disparities in Salivary Gland Cancer Survival. JAMA otolaryngology-- head & neck surgery. 2014;140(6):504-12.
• 12. da Silva L, Serpa M, da Silva L, Sobral A. Central mucoepidermoid carcinoma radiographically mimicking an odontogenic tumor: A case report and literature review. Journal of Oral and Maxillofacial Pathology. 2016;20(3):518-22.
• 13. Kato H, Kanematsu M, Makita H, Kato K, Hatakeyama D, Shibata T, et al. CT and MR imaging findings of palatal tumors. European journal of radiology. 2014;83(3):e137-e46.
• 14. Liu S, Ow A, Ruan M, Yang W, Zhang C, Wang L, et al. Prognostic factors in primary salivary gland mucoepidermoid carcinoma: an analysis of 376 cases in an Eastern Chinese population. International Journal of Oral and Maxillofacial surgery. 2014;43(6):667-73.
• 15. Ali SA, Memon AS, Shaik NA, Soomro AG. Mucoepidermoid carcinoma of parotid presenting as unilocular cyst. J Ayub Med Coll Abbottabad. 2008;20(2):141-43.