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Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients

Yıl 2024, Cilt: 8 Sayı: 2, 483 - 489, 31.05.2024
https://doi.org/10.30621/jbachs.1416117

Öz

Kaynakça

  • Nathwani AC. Gene therapy for hemophilia. Hematology Am Soc Hematol Educ Program. 2019;2019(1):1-8.
  • Franchini M, Mannucci PM. Co-morbidities and quality of life in elderly persons with haemophilia. Br J Haematol. 2010;148(4):522-33.
  • Aledort L, Bullinger M, von Mackensen S, et al. Why should we care about quality of life in persons with haemophilia? Haemophilia. 2012;18(3):e154-7.
  • Kempton CL, Makris M, Holme PA. Management of comorbidities in haemophilia. Haemophilia. 2021;27 Suppl 3:37-45.
  • Mannucci PM. Aging with Hemophilia: The Challenge of Appropriate Drug Prescription. Mediterr J Hematol Infect Dis. 2019;11(1):e2019056.
  • Alam AU, Goodyear MD, Wu C, et al. Increased acute care utilisation, comorbidities and mortality in adults with haemophilia: A population-based cohort study from 2012 to 2019. Haemophilia. 2023;29(1):219-229.
  • Shapiro S, Makris M. Haemophilia and ageing. Br J Haematol. 2019;184(5):712-720.
  • Skjefstad K, Solberg O, Glosli H, et al. Life expectancy and cause of death in individuals with haemophilia A and B in Norway, 1986-2018. Eur J Haematol. 2020;105(5):608-615.
  • Kavakli K, Aktuglu G, Kemahli S, et al. Inhibitor screening for patients with hemophilia in Turkey. Turk J Haematol. 2006;23(1):25-32.
  • Ghosh K, Shetty S, Kulkarni B, et al. Development of inhibitors in patients with haemophilia from India. Haemophilia. 2001;7(3):273-8.
  • Oren H, Yaprak I, Irken G. Factor VIII inhibitors in patients with hemophilia A. Acta Haematol. 1999;102(1):42-6.
  • Lusher JM, Arkin S, Abildgaard CF, et al. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med. 1993;328(7):453-9.
  • Marchesini E, Oliovecchio E, Coppola A, et al. Comorbidities in persons with haemophilia aged 60 years or more compared with age-matched people from the general population. Haemophilia. 2018;24(1):e6-e10.
  • Curtis R, Baker J, Riske B, et al. Young adults with hemophilia in the U.S.: demographics, comorbidities, and health status. Am J Hematol. 2015;90 Suppl 2:S11-6.
  • Sun J, Zhao Y, Yang R, et al. The demographics, treatment characteristics and quality of life of adult people with haemophilia in China - results from the HERO study. Haemophilia. 2017;23(1):89-97.
  • Fransen van de Putte DE, Fischer K, Makris M, et al. Increased prevalence of hypertension in haemophilia patients. Thromb Haemost. 2012;108(4):750-5.
  • Siboni SM, Mannucci PM, Gringeri A, et al. Health status and quality of life of elderly persons with severe hemophilia born before the advent of modern replacement therapy. J Thromb Haemost. 2009;7(5):780-6.
  • Chang CY, Li TY, Cheng SN, et al. Obesity and overweight in patients with hemophilia: Prevalence by age, clinical correlates, and impact on joint bleeding. J Chin Med Assoc. 2019 ;82(4):289-294.
  • Santos EM, Silva JM, Barbosa AN, et al. Clinico-epidemiological and sociodemographic profile of patients with hemophilia in the Brazilian Amazon: High prevalence of hepatitis C infection and its possible corrrelation with inhibitor development. Front Public Health. 2022;10:963790.

Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients

Yıl 2024, Cilt: 8 Sayı: 2, 483 - 489, 31.05.2024
https://doi.org/10.30621/jbachs.1416117

Öz

Purpose: The association between socio-demographic factors and hemophilia status and the prevalence of comorbidities were evaluated.
Material and Methods: Patients with hemophilia A (n=111) and B (n=24) who were filled a questionnaire form about their sociodemographic factors were included in our study. Factor and inhibitor levels, comorbidities, factor replacement therapies, hemophilic arthropathy, viral status and annual bleeding episodes were recorded.
Results: Median age was 39 years in 135 hemophilia patients and 63.1 % of all the patients had severe hemophilia which was significantly higher among hemophilia A patients (p=0.002). Most of the patients (74.8%) were treated with prophylactic factor replacement therapy. Inhibitor status was positive in 8.9% of all patients. Unemployment rate was found 33.3%. Annual bleeding episodes were higher in patients who had a job. Most of the patients (60 %) were graduated from at least high school. The prevalence of cardiovascular disease, hypertension, diabetes mellitus and obesity were 6.7%; 17.8%, 13.3%, 11.9% respectively. Although there is no association between the obesity and annual bleeding episodes, right ankle was the most affected joint in overweight/obese patients.
Conclusion: Age-related comorbidities and the relation of hemophilia status and social life are needed to be more investigated.

Etik Beyan

The study was approved by Ege University, Clinical Research Ethics Committee (Date: 09.08.2016, Decision No: 16-7/1).

Destekleyen Kurum

The authors declare no conflict of interest.

Teşekkür

None

Kaynakça

  • Nathwani AC. Gene therapy for hemophilia. Hematology Am Soc Hematol Educ Program. 2019;2019(1):1-8.
  • Franchini M, Mannucci PM. Co-morbidities and quality of life in elderly persons with haemophilia. Br J Haematol. 2010;148(4):522-33.
  • Aledort L, Bullinger M, von Mackensen S, et al. Why should we care about quality of life in persons with haemophilia? Haemophilia. 2012;18(3):e154-7.
  • Kempton CL, Makris M, Holme PA. Management of comorbidities in haemophilia. Haemophilia. 2021;27 Suppl 3:37-45.
  • Mannucci PM. Aging with Hemophilia: The Challenge of Appropriate Drug Prescription. Mediterr J Hematol Infect Dis. 2019;11(1):e2019056.
  • Alam AU, Goodyear MD, Wu C, et al. Increased acute care utilisation, comorbidities and mortality in adults with haemophilia: A population-based cohort study from 2012 to 2019. Haemophilia. 2023;29(1):219-229.
  • Shapiro S, Makris M. Haemophilia and ageing. Br J Haematol. 2019;184(5):712-720.
  • Skjefstad K, Solberg O, Glosli H, et al. Life expectancy and cause of death in individuals with haemophilia A and B in Norway, 1986-2018. Eur J Haematol. 2020;105(5):608-615.
  • Kavakli K, Aktuglu G, Kemahli S, et al. Inhibitor screening for patients with hemophilia in Turkey. Turk J Haematol. 2006;23(1):25-32.
  • Ghosh K, Shetty S, Kulkarni B, et al. Development of inhibitors in patients with haemophilia from India. Haemophilia. 2001;7(3):273-8.
  • Oren H, Yaprak I, Irken G. Factor VIII inhibitors in patients with hemophilia A. Acta Haematol. 1999;102(1):42-6.
  • Lusher JM, Arkin S, Abildgaard CF, et al. Recombinant factor VIII for the treatment of previously untreated patients with hemophilia A. Safety, efficacy, and development of inhibitors. Kogenate Previously Untreated Patient Study Group. N Engl J Med. 1993;328(7):453-9.
  • Marchesini E, Oliovecchio E, Coppola A, et al. Comorbidities in persons with haemophilia aged 60 years or more compared with age-matched people from the general population. Haemophilia. 2018;24(1):e6-e10.
  • Curtis R, Baker J, Riske B, et al. Young adults with hemophilia in the U.S.: demographics, comorbidities, and health status. Am J Hematol. 2015;90 Suppl 2:S11-6.
  • Sun J, Zhao Y, Yang R, et al. The demographics, treatment characteristics and quality of life of adult people with haemophilia in China - results from the HERO study. Haemophilia. 2017;23(1):89-97.
  • Fransen van de Putte DE, Fischer K, Makris M, et al. Increased prevalence of hypertension in haemophilia patients. Thromb Haemost. 2012;108(4):750-5.
  • Siboni SM, Mannucci PM, Gringeri A, et al. Health status and quality of life of elderly persons with severe hemophilia born before the advent of modern replacement therapy. J Thromb Haemost. 2009;7(5):780-6.
  • Chang CY, Li TY, Cheng SN, et al. Obesity and overweight in patients with hemophilia: Prevalence by age, clinical correlates, and impact on joint bleeding. J Chin Med Assoc. 2019 ;82(4):289-294.
  • Santos EM, Silva JM, Barbosa AN, et al. Clinico-epidemiological and sociodemographic profile of patients with hemophilia in the Brazilian Amazon: High prevalence of hepatitis C infection and its possible corrrelation with inhibitor development. Front Public Health. 2022;10:963790.
Toplam 19 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Klinik Tıp Bilimleri (Diğer)
Bölüm Research Article
Yazarlar

Fatma Keklik Karadağ 0000-0001-6078-5944

Zühal Demirci 0000-0001-7509-8020

Fatoş Dilan Köseoğlu 0000-0002-3947-0355

Güray Saydam 0000-0001-8646-1673

Fahri Şahin 0000-0001-9315-8891

Yayımlanma Tarihi 31 Mayıs 2024
Gönderilme Tarihi 7 Ocak 2024
Kabul Tarihi 10 Mayıs 2024
Yayımlandığı Sayı Yıl 2024 Cilt: 8 Sayı: 2

Kaynak Göster

APA Keklik Karadağ, F., Demirci, Z., Köseoğlu, F. D., Saydam, G., vd. (2024). Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients. Journal of Basic and Clinical Health Sciences, 8(2), 483-489. https://doi.org/10.30621/jbachs.1416117
AMA Keklik Karadağ F, Demirci Z, Köseoğlu FD, Saydam G, Şahin F. Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients. JBACHS. Mayıs 2024;8(2):483-489. doi:10.30621/jbachs.1416117
Chicago Keklik Karadağ, Fatma, Zühal Demirci, Fatoş Dilan Köseoğlu, Güray Saydam, ve Fahri Şahin. “Evaluation of Socio-Demographic Factors and Comorbidities in Adult Hemophilia Patients”. Journal of Basic and Clinical Health Sciences 8, sy. 2 (Mayıs 2024): 483-89. https://doi.org/10.30621/jbachs.1416117.
EndNote Keklik Karadağ F, Demirci Z, Köseoğlu FD, Saydam G, Şahin F (01 Mayıs 2024) Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients. Journal of Basic and Clinical Health Sciences 8 2 483–489.
IEEE F. Keklik Karadağ, Z. Demirci, F. D. Köseoğlu, G. Saydam, ve F. Şahin, “Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients”, JBACHS, c. 8, sy. 2, ss. 483–489, 2024, doi: 10.30621/jbachs.1416117.
ISNAD Keklik Karadağ, Fatma vd. “Evaluation of Socio-Demographic Factors and Comorbidities in Adult Hemophilia Patients”. Journal of Basic and Clinical Health Sciences 8/2 (Mayıs 2024), 483-489. https://doi.org/10.30621/jbachs.1416117.
JAMA Keklik Karadağ F, Demirci Z, Köseoğlu FD, Saydam G, Şahin F. Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients. JBACHS. 2024;8:483–489.
MLA Keklik Karadağ, Fatma vd. “Evaluation of Socio-Demographic Factors and Comorbidities in Adult Hemophilia Patients”. Journal of Basic and Clinical Health Sciences, c. 8, sy. 2, 2024, ss. 483-9, doi:10.30621/jbachs.1416117.
Vancouver Keklik Karadağ F, Demirci Z, Köseoğlu FD, Saydam G, Şahin F. Evaluation of Socio-demographic Factors and Comorbidities in Adult Hemophilia Patients. JBACHS. 2024;8(2):483-9.