ID Besin Proteini İlişkili Enterokolit Sendromu

Yıl 2019, Cilt: 19 Sayı: 1, 1 - 9, 01.04.2019

Zeynep Hızlı Demirkale Zeynep Tamay

https://doi.org/10.5222/j.child.2019.08760

Öz

Besin proteini ilişkili enterokolit sendromu BPİES , immunglobulin E IgE aracılı olmayan besin alerjisidir. BPİES’in patofizyolojisi henüz tam aydınlatılamamakla birlikte, patofizyolojisinde hücre aracılı mekanizmaların sorumlu olduğu düşünülmektedir. Akut ve kronik olmak üzere iki şekilde sınıflandırılır. Tanı koydurucu laboratuvar testleri yoktur fakat ayırıcı tanıya giren diğer hastalıklar için laboratuvar yöntemlerinden yararlanılabilir. Tanı şüpheli besin diyetten çıkarıldıktan sonra yakınmaların tamamen düzelmesi ve besin provokasyonla yine verildiğinde akut BPİES bulgularının oluşması ile konulur. Akut BPİES sık görülen diğer çocukluk çağı hastalıkları ile karıştırılabilir. Bu derlemede, BPİES’in klinik bulguları, tanısı, ayırıcı tanıya giren hastalıkları, tedavisi ve izlemi son yayınlar ve öneriler eşliğinde incelenmiştir

Anahtar Kelimeler

Besin protein ilişkili enterokolit sendromu, IgE aracılı olmayan besin alerjisi, besin alerjisi, BPİES

Food Protein-Induced Enterocolitis Syndrome

Öz

Food protein–induced enterocolitis syndrome FPIES is a non-immunoglobulin E IgE - mediated food allergy. However, the exact pathophysiology of FPIES is not clearly understood, cell mediated mechanisms are considered to be responsible. FPIES is classified in two forms: acute and chronic. There are no diagnostic laboratory tests for FPIES but laboratory methods can be used for other diseases in the differential diagnosis. The diagnosis of FPIES is based on clinical responses to elimination of suspected diets with resolution of symptoms, oral food challenges with reappearance of symptoms following provocation test by providing the offending food. Acute FPIES can be confused with other frequently seen childhood diseases. In this review, the clinical findings, diagnosis, diseases included in the differential diagnosis, treatments and follow-up of FPIES are examined in the light of the latest publications and recommendations.

Anahtar Kelimeler

Food protein–induced enterocolitis syndrome, non-IgE mediated food allergy, food allergy, FPIES

Kaynakça

• 1. Wuthrich B. History of food allergy. Chem Immunol Allergy 2014;100:109-19. https://doi.org/10.1159/000358616
• 2. Rubin M. Allergic intestinal bleeding in the newborn. Am J Med Sci. 1940;200:385-7. https://doi.org/10.1097/00000441-194009000-00014
• 3. Gryboski J. Gastrointestinal milk allergy in infancy. Pediatrics 1967;40:354-62.
• 4. Powell GK. Enterocolitis in low-birth-weight infants associated with milk and soy protein intolerance. J Pediatr. 1976;88:840-4. https://doi.org/10.1016/S0022-3476(76)81128-6
• 5. Powell GK. Milk- and soy-induced enterocolitis of infancy. J Pediatr. 1978;93:553-60. https://doi.org/10.1016/S0022-3476(78)80887-7
• 6. WHO. ICD-10. http://wwwwhoint/classifications/icd/en/.
• 7. Nowak Wegrzyn A, et al. International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary -Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology. J Allergy Clin Immunol. 2017;139:1111-26. https://doi.org/10.1016/j.jaci.2016.12.966
• 8. Nowak Wegrzyn A, Jarocka-Cyrta E, Castro Moschione A. Food Protein-induced enterocolitis syndrome. J Investig Allergol Clin Immunol. 2017;27:1-18. https://doi.org/10.18176/jiaci.0135
• 9. Katz Y, Goldberg MR, Rajuan N, Cohen A, Leshno M. The prevalence and natural course of food proteininduced enterocolitis syndrome to cow’s milk: a largescale, prospective population-based study. J Allergy Clin Immunol. 2011;127:647-53. https://doi.org/10.1016/j.jaci.2010.12.1105
• 10. Mehr S, et al. Food protein-induced enterocolitis syndrome in Australia: A population-based study, 2012-2014. J Allergy Clin Immunol. 2017:140:1323- 30. https://doi.org/10.1016/j.jaci.2017.03.027
• 11. Nomura I, et al. Four distinct subtypes of non-IgE mediated gastrointestinal food allergies in neonates and infants, distinguished by their initial symptoms. J Allergy Clin Immunol. 2011;127:685. https://doi.org/10.1016/j.jaci.2011.01.019
• 12. Caubet JM FL, Sickles L, Järvinen KM, Sicherer SH, Sampson HA, Nowak-Węgrzyn A. Clinical features and resolution of food protein-induced enterocolitis syndrome: 10-year experience. J Allergy Clin Immunol. 2014;134:382-9. https://doi.org/10.1016/j.jaci.2014.04.008
• 13. Leonard SA, et al. Food protein-induced enterocolitis syndrome: a review of the new guidelines. World Allergy Organ J. 2018;11:4. https://doi.org/10.1186/s40413-017-0182-z
• 14. Mehr S, Kakakios A, Frith K, Kemp AS. Food protein-induced enterocolitis syndrome: 16-year experience. Pediatrics 2009;123:e459-64. https://doi.org/10.1542/peds.2008-2029
• 15. Murray KCD. Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea. J Pediatr. 1993;122:90-2. https://doi.org/10.1016/S0022-3476(05)83495-X
• 16. Goldman H, Proujansky R. Allergic proctitis and gastroenteritis in children. Clinical and mucosal biopsy features in 53 cases. Am J Surg Pathol. 1986;10:75. https://doi.org/10.1097/00000478-198602000-00001
• 17. Sicherer SH. Food protein-induced enterocolitis syndrome: Case presentations and management lessons. J Allergy Clin Immunol. 2005;115:149-56. https://doi.org/10.1016/j.jaci.2004.09.033
• 18. Sopo SM, et al. A multicentre retrospective study of 66 Italian children with food protein-induced enterocolitis syndrome: different management for different phenotypes. Clin Exp Allergy 2012;42:1257. https://doi.org/10.1111/j.1365-2222.2012.04027.x
• 19. Nowak Wegrzyn A, Muraro A. Food protein-induced enterocolitis syndrome. Curr Opin Allergy Clin Immunol. 2009;9:371. https://doi.org/10.1097/ACI.0b013e32832d6315
• 20. Onesimo R, et al. Can food protein-induced enterocolitis syndrome shift to immediate gastrointestinal hypersensitivity? A report of two cases. Eur Ann Allergy Clin Immunol. 2011;43:61.
• 21. Jayasooriya S, Fox AT, Murch SH. Do not laparotomize food protein-induced enterocolitis syndrome. Pediatr Emerg Care 2007;23:173-5. https://doi.org/10.1097/PEC.0b013e318032
• 22. Miceli Sopo S, et al. Food protein-induced enterocolitis syndrome caused by fish and/or shellfish in Italy. Pediatr Allergy Immunol. 2015;26:731-6. https://doi.org/10.1111/pai.12461
• 23. Vila L, Garcia V, Rial MJ, Novoa E, Cacharron T. Fish is a major trigger of solid food protein-induced enterocolitis syndrome in Spanish children. J Allergy Clin Immunol Pract. 2015;3:621-3. https://doi.org/10.1016/j.jaip.2015.03.006
• 24. Yilmaz EA, et al. Characteristics of children with food protein-induced enterocolitis and allergic proctocolitis. Allergy Asthma Proceed. 2017;38:54-62. https://doi.org/10.2500/aap.2017.38.4023
• 25. Monti G, et al. Food protein-induced enterocolitis syndrome by cow’s milk proteins passed through breast milk. J Allergy Clin Immunol. 2011;127:679. https://doi.org/10.1016/j.jaci.2010.10.017
• 26. Sopo SM, et al. Chronic food protein-induced enterocolitis syndrome caused by cow’s milk proteins passed through breast milk. Int Arch Allergy Immunol. 2014;164:207-209. https://doi.org/10.1159/000365104
• 27. Kaya A, et al. Food protein-induced enterocolitis syndrome in two exclusively breastfed infants. Pediatr Allergy Immunol. 2016;27:749. https://doi.org/10.1111/pai.12605
• 28. Fernandes BN, Boyle RJ, Gore C, Simpson A, Custovic A. Food protein-induced enterocolitis syndrome can occur in adults. J Allergy Clin Immunol. 2012;130:1199- 200. https://doi.org/10.1016/j.jaci.2012.06.017
• 29. Sicherer SH. Food protein-induced entercolitis syndrome: clinical perspectives. J Pediatr Gastroenterol Nutr. 2000;30:45-9. https://doi.org/10.1097/00005176-200001001-00007
• 30. Nowak-Wegrzyn A, Assa’ad AH, Bahna SL, Bock SA, Sicherer SH, Teuber SS. Work Group report: oral food challenge testing. J Allergy Clin Immunol. 2009;123:S365-83. https://doi.org/10.1016/j.jaci.2009.03.042
• 31. Jarvinen K, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome: Current management strategies. J Allergy Clin Immunol Pract. 2013;1:317. https://doi.org/10.1016/j.jaip.2013.04.004
• 32. de Boissieu D, Matarazzo P, Dupont C. Allergy to extensively hydrolyzed cow milk proteins in infants: identification and treatment with an amino acid based formula. J Pediatr. 1997;131:744. https://doi.org/10.1016/S0022-3476(97)70104-5
• 33. Martorell-Aragonés A, et al. Position document: IgEmediated cow’s milk allergy. Allergol Immunopathol. 2015;43:507-26. https://doi.org/10.1016/j.aller.2015.01.003
• 34. Nowak Wegrzyn A, Sampson HA, Wood RA, Sicherer SH. Food protein-induced enterocolitis syndrome caused by solid food proteins. Pediatrics 2003;111: 829. https://doi.org/10.1542/peds.111.4.829
• 35. Liu AH, et al. National prevalence and risk factors for food allergy and relationship to asthma: results from the National Health and Nutrition Examination Survey 20052006. J Allergy Clin Immunol. 2010;126:798. https://doi.org/10.1016/j.jaci.2010.07.026
• 36. Holbrook T, Keet CA, Frischmeyer Guerrerio PA, Wood RA. Use of ondansetron for food protein-induced enterocolitis syndrome. J Allergy Clin Immunol. 2013;132:1219. https://doi.org/10.1016/j.jaci.2013.06.021
• 37. Miceli Sopo S, Battista A, Greco M, Monaco S. Ondansetron for food protein-induced enterocolitis syndrome. Int Arch Allergy Immunol. 2014;164:137. https://doi.org/10.1159/000363384
• 38. Hwang JB, Sohn SM, Kim AS. Prospective follow-up oral food challenge in food protein-induced enterocolitis syndrome. Arch Dis Child. 2009;94:425. https://doi.org/10.1136/adc.2008.143289
• 39. Meyer R, et al. Manifestations of food protein-induced gastrointestinal allergies presenting to a single tertiary pediatric gastroenterology unit. World Allergy Organ J. 2013;6:13. https://doi.org/10.1186/1939-4551-6-13