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A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction

Yıl 2021, Cilt 21, Sayı 2, 215 - 217, 20.09.2021

Öz

Cetirizine is a selective H1 histamine receptor antagonist derived from piperazine. Piperazine is a cyclic moiety molecule located in the structure of many drugs, including anxiolytics, antidepressants, and antipsychotics. Drug-induced dystonia is reported mostly due to antipsychotic and antiemetic drugs. It occurs due to the disruption of dopamine and acetylcholine balance in favor of acetylcholine. Although cetirizine is a relatively safe drug, it has rarely been reported to cause a dystonic reaction. To the best of our knowledge, there is no reported case of dystonia due to cetirizine in infancy. Here, we present a 7-month-old patient who developed a dystonic reaction after cetirizine administration.

Kaynakça

  • 1. Brito AF, Moreira LKS, Menegatti R, Costa EA. Piperazine derivatives with central pharmacological activity used as therapeutic tools. Fundam Clin Pharmacol 2019;33(1):13-24. doi: 10.1111/fcp.12408. Epub 2018 Sep 17. google scholar
  • 2. Singh K, Siddiqui HH, Shakya P, Bagga P, Kumar A, Khalid, M et al. Piperazine - A biologically active scaffold. Int J Pharm Sci Res 2015;6(10);4145-58. google scholar
  • 3. Fitzsimons R, van der Poel LA, Thornhill W et al. Antihistamine use in children. Arch Dis Child Educ Pract Ed 2015;100(3):122-31. doi: 10.1136/archdischild-2013-304446. Epub 2014 Aug 21. google scholar
  • 4. Kawauchi H, Yanai K, Wang DY, Itahashi K, Okubo K. Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci 2019;20(1). pii: E213. doi: 10.3390/ ijms20010213. google scholar
  • 5. Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, et al. The clinical pharmacology of non-sedating antihistamines. Pharmacol Ther 2017;178:148-56. google scholar
  • 6. Rajan S, Kaas B, Moukheiber E. Movement disorders emergencies. Semin Neurol 2019;39(1):125-36. doi: 10.1055/s-0038-1677050. Epub 2019 Feb 11. google scholar
  • 7. Sharawat IK, Dawman L. Acute focal dystonia after a single dose of oral cetirizine in a 9-year-old boy. Pediatr Emerg Care 2019;35(2):e30-e31. doi: 10.1097/PEC. 0000000000001062 google scholar
  • 8. Esen I, Demirpence S, Yis U, Kurul S. Cetirizine-induced dystonic reaction in a 6-year-old boy. Pediatr Emerg Care 2008;24(9):627-8. doi: 10.1097/PEC.0b013e3181850c35. google scholar
  • 9. Rajput A, Baerg K. Cetirizine-induced dystonic movements. Neurology 2006;66:143-44. google scholar
  • 10. Yılmaz-Topal Ö, Tuygun N, Akça H, Polat E, Karacan CD. Cetirizine and albendazole induced dystonia in a child. Turk J Pediatr 2015;57(4):407-8. google scholar
  • 11. Sânchez-Borges M, Ansotegui IJ. Second generation antihistamines: An update. Curr Opin Allergy Clin Immunol 2019;19(4):358-64. doi: 10.1097/ACI.0000000000000556. google scholar
  • 12. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30(2):239-45. google scholar

Yedi Aylık Bebekte Setirizin’in Nadir Bir Yan Etkisi: Distonik Reaksiyon

Yıl 2021, Cilt 21, Sayı 2, 215 - 217, 20.09.2021

Öz

Setirizin, piperazinden türetilen seçici bir H1 histamin reseptör antagonis- tidir. Piperazin, anksiyolitikler, antidepresanlar ve antipsikotikler dahil olmak üzere birçok ilacın yapısında yer alan siklik bir moleküldür. İlaca bağlı distoni, çoğunlukla antipsikotik ve antiemetik ilaçlara bağlı olarak bildirilmektedir. Dopamin ve asetilkolin dengesinin asetilkolin lehine bozulması sonucu oluşur. Setirizin nispeten güvenli bir ilaç olmasına rağ- men, nadiren distonik reaksiyona neden olduğu bildirilmiştir. Şimdiye kadar süt çocukluğu döneminde setirizine bağlı olarak bildirilmiş bir dis- toni vakası yoktur. Burada setirizin uygulaması sonrası distonik reaksiyon gelişen 7 aylık bir hasta sunulmuştur.

Kaynakça

  • 1. Brito AF, Moreira LKS, Menegatti R, Costa EA. Piperazine derivatives with central pharmacological activity used as therapeutic tools. Fundam Clin Pharmacol 2019;33(1):13-24. doi: 10.1111/fcp.12408. Epub 2018 Sep 17. google scholar
  • 2. Singh K, Siddiqui HH, Shakya P, Bagga P, Kumar A, Khalid, M et al. Piperazine - A biologically active scaffold. Int J Pharm Sci Res 2015;6(10);4145-58. google scholar
  • 3. Fitzsimons R, van der Poel LA, Thornhill W et al. Antihistamine use in children. Arch Dis Child Educ Pract Ed 2015;100(3):122-31. doi: 10.1136/archdischild-2013-304446. Epub 2014 Aug 21. google scholar
  • 4. Kawauchi H, Yanai K, Wang DY, Itahashi K, Okubo K. Antihistamines for allergic rhinitis treatment from the viewpoint of nonsedative properties. Int J Mol Sci 2019;20(1). pii: E213. doi: 10.3390/ ijms20010213. google scholar
  • 5. Yanai K, Yoshikawa T, Yanai A, Nakamura T, Iida T, Leurs R, et al. The clinical pharmacology of non-sedating antihistamines. Pharmacol Ther 2017;178:148-56. google scholar
  • 6. Rajan S, Kaas B, Moukheiber E. Movement disorders emergencies. Semin Neurol 2019;39(1):125-36. doi: 10.1055/s-0038-1677050. Epub 2019 Feb 11. google scholar
  • 7. Sharawat IK, Dawman L. Acute focal dystonia after a single dose of oral cetirizine in a 9-year-old boy. Pediatr Emerg Care 2019;35(2):e30-e31. doi: 10.1097/PEC. 0000000000001062 google scholar
  • 8. Esen I, Demirpence S, Yis U, Kurul S. Cetirizine-induced dystonic reaction in a 6-year-old boy. Pediatr Emerg Care 2008;24(9):627-8. doi: 10.1097/PEC.0b013e3181850c35. google scholar
  • 9. Rajput A, Baerg K. Cetirizine-induced dystonic movements. Neurology 2006;66:143-44. google scholar
  • 10. Yılmaz-Topal Ö, Tuygun N, Akça H, Polat E, Karacan CD. Cetirizine and albendazole induced dystonia in a child. Turk J Pediatr 2015;57(4):407-8. google scholar
  • 11. Sânchez-Borges M, Ansotegui IJ. Second generation antihistamines: An update. Curr Opin Allergy Clin Immunol 2019;19(4):358-64. doi: 10.1097/ACI.0000000000000556. google scholar
  • 12. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30(2):239-45. google scholar

Ayrıntılar

Birincil Dil İngilizce
Konular Pediatri
Bölüm Olgu Sunumu
Yazarlar

Ayşe SÜLEYMAN
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0002-9190-6849
Türkiye


Esra ÖZEK (Sorumlu Yazar)
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0003-3712-2522
Türkiye


Zeynep HIZLI DEMİRKALE
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0001-6159-9895
Türkiye


Sevgi SİPAHİ ÇİMEN Bu kişi benim
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0003-3026-0906
Türkiye


Ayşe KILIÇ
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of General Pediatrics, Istanbul, Turkey
0000-0003-3217-4075
Türkiye


Cevdet ÖZDEMİR
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0002-9284-4520
Türkiye


Nermin GÜLER
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0002-9702-0491
Türkiye


Zeynep Ülker TAMAY
Istanbul University, Istanbul Faculty of Medicine, Department of Pediatrics, Department of Pediatric Immunology and Allergy Diseases, Istanbul, Turkey
0000-0002-3200-5493
Türkiye

Destekleyen Kurum yoktur
Yayımlanma Tarihi 20 Eylül 2021
Yayınlandığı Sayı Yıl 2021, Cilt 21, Sayı 2

Kaynak Göster

Bibtex @olgu sunumu { jchild755569, journal = {Çocuk Dergisi}, issn = {}, eissn = {1308-8491}, address = {Çocuk Dergisi Yayın Kurulu Sekreterliği İstanbul Tıp Fakültesi, Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Çapa, 34390, İstanbul}, publisher = {İstanbul Üniversitesi}, year = {2021}, volume = {21}, pages = {215 - 217}, doi = {}, title = {A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction}, key = {cite}, author = {Süleyman, Ayşe and Özek, Esra and Hızlı Demirkale, Zeynep and Sipahi Çimen, Sevgi and Kılıç, Ayşe and Özdemir, Cevdet and Güler, Nermin and Tamay, Zeynep Ülker} }
APA Süleyman, A. , Özek, E. , Hızlı Demirkale, Z. , Sipahi Çimen, S. , Kılıç, A. , Özdemir, C. , Güler, N. & Tamay, Z. Ü. (2021). A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction . Çocuk Dergisi , 21 (2) , 215-217 . Retrieved from https://dergipark.org.tr/tr/pub/jchild/issue/64961/755569
MLA Süleyman, A. , Özek, E. , Hızlı Demirkale, Z. , Sipahi Çimen, S. , Kılıç, A. , Özdemir, C. , Güler, N. , Tamay, Z. Ü. "A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction" . Çocuk Dergisi 21 (2021 ): 215-217 <https://dergipark.org.tr/tr/pub/jchild/issue/64961/755569>
Chicago Süleyman, A. , Özek, E. , Hızlı Demirkale, Z. , Sipahi Çimen, S. , Kılıç, A. , Özdemir, C. , Güler, N. , Tamay, Z. Ü. "A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction". Çocuk Dergisi 21 (2021 ): 215-217
RIS TY - JOUR T1 - A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction AU - Ayşe Süleyman , Esra Özek , Zeynep Hızlı Demirkale , Sevgi Sipahi Çimen , Ayşe Kılıç , Cevdet Özdemir , Nermin Güler , Zeynep Ülker Tamay Y1 - 2021 PY - 2021 N1 - DO - T2 - Çocuk Dergisi JF - Journal JO - JOR SP - 215 EP - 217 VL - 21 IS - 2 SN - -1308-8491 M3 - UR - Y2 - 2021 ER -
EndNote %0 Çocuk Dergisi A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction %A Ayşe Süleyman , Esra Özek , Zeynep Hızlı Demirkale , Sevgi Sipahi Çimen , Ayşe Kılıç , Cevdet Özdemir , Nermin Güler , Zeynep Ülker Tamay %T A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction %D 2021 %J Çocuk Dergisi %P -1308-8491 %V 21 %N 2 %R %U
ISNAD Süleyman, Ayşe , Özek, Esra , Hızlı Demirkale, Zeynep , Sipahi Çimen, Sevgi , Kılıç, Ayşe , Özdemir, Cevdet , Güler, Nermin , Tamay, Zeynep Ülker . "A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction". Çocuk Dergisi 21 / 2 (Eylül 2021): 215-217 .
AMA Süleyman A. , Özek E. , Hızlı Demirkale Z. , Sipahi Çimen S. , Kılıç A. , Özdemir C. , Güler N. , Tamay Z. Ü. A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction. Çocuk Dergisi. 2021; 21(2): 215-217.
Vancouver Süleyman A. , Özek E. , Hızlı Demirkale Z. , Sipahi Çimen S. , Kılıç A. , Özdemir C. , Güler N. , Tamay Z. Ü. A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction. Çocuk Dergisi. 2021; 21(2): 215-217.
IEEE A. Süleyman , E. Özek , Z. Hızlı Demirkale , S. Sipahi Çimen , A. Kılıç , C. Özdemir , N. Güler ve Z. Ü. Tamay , "A Rare Adverse Effect of Cetirizine in a 7- Month-Old Infant: Dystonic Reaction", Çocuk Dergisi, c. 21, sayı. 2, ss. 215-217, Eyl. 2021