ankara ecz. fak. derg. Journal of Faculty of Pharmacy of Ankara University 1015-3918 2564-6524 Ankara Üniversitesi 10.33483/jfpau.1588378 Pharmaceutical Biochemistry Eczacılık Biyokimyası OBEZ ÇOCUKLARDA SERUM ADİPOKİN HORMON DÜZEYLERİNİN OBEZİTE DERECELERİ VE BAZI BELİRTEÇLERİ İLE İLİŞKİSİNİN İNCELENMESİ EXAMINATION OF THE RELATIONSHIP OF SERUM ADIPOKINE HORMONE LEVELS WITH THE DEGREE AND SOME MARKERS OF OBESITY IN OBESE CHILDREN https://orcid.org/0000-0002-6170-4349 Demirbilek Kayalı Merve GAZI UNIVERSITY https://orcid.org/0000-0002-8376-1328 Fakıoğlu Dolunay Merve GAZI UNIVERSITY https://orcid.org/0000-0003-2865-4420 Buluş Derya UNIVERSITY OF HEALTH SCIENCES, ANKARA KEÇİÖREN EDUCATION AND RESEARCH HOSPITAL https://orcid.org/0000-0002-8567-907X Fakıoğlu Erhan UNIVERSITY OF HEALTH SCIENCES, ANKARA KEÇİÖREN HEALTH RESEARCH CENTER https://orcid.org/0000-0002-4424-5232 Kışlal Fatih Mehmet SAĞLIK BİLİMLERİ ÜNİVERSİTESİ, ANKARA KEÇİÖREN SAĞLIK UYGULAMA VE ARAŞTIRMA MERKEZİ https://orcid.org/0000-0002-0927-5188 Akaydın Sevgi Gazı University 05 19 2025 49 2 437 446 12 15 2024 02 26 2025 Copyright © 1971, Ankara Üniversitesi Eczacılık Fakültesi Dergisi 1971 Ankara Üniversitesi Eczacılık Fakültesi Dergisi

Amaç: Obezite, vücuttaki yağ dokusunun aşırı artışı olarak tanımlanır. Yağ dokusu ayrıca metabolizma ve enerji homeostazında önemli rol oynayan leptin, adiponektin, asprosin ve apelin gibi adipokin hormonlarının salgılanmasını sağlar. Bu nedenle, sadece yağ dokusundaki artış değil, yağ dokusundan salgılanan bu adipokin hormonlarının düzeylerindeki değişiklikler çocukluk çağı obezitesini belirlemede ve patolojik mekanizmaları açıklamada etkilidir. Bu polipeptitlerin değerlendirilmesi obezitenin tanısında ve obeziteyle ilişkili patolojik mekanizmaların aydınlatılmasında etkili olacaktır.Gereç ve Yöntem: Çalışmamız, obez çocukların serum leptin, adiponektin, asprosin ve apelin düzeyleri gibi bazı obezite belirteçleri ile kan lipitleri, açlık kan şekeri ve insülin direnci indeksi (HOMA-IR) değerleri arasındaki ilişkiyi ortaya koymak amacıyla yapıldı. Çalışmamıza 105 obez çocuk ve 38 normal kilolu çocuk dahil edildi. Çocukların demografik bilgileri yüz yüze anket yöntemi ile belirlendi. Leptin, adiponektin, asprosin ve apelin düzeyleri obez ve normal kilolu çocuklardan alınan sabah açlık kan örneklerinde ticari Elisa kiti yardımıyla tayin edildi.Sonuç ve Tartışma: Leptin ve adiponektin düzeyleri obez ve normal kilolu çocuklarda farklı değildi (p>0,05). Asprosin ve apelin düzeyleri obez çocuklarda normal kilolu çocuklara göre anlamlı olarak yüksek bulundu (p<0,001). Hem obez hem de normal kilolu çocuklarda adipokin hormonları arasında pozitif korelasyonlar gözlendi. Leptin/asprosin, leptin/apelin, adiponektin/asprosin, adiponektin/apelin, asprosin/apelin oranları obez çocuklarda normal kilolu çocuklara göre istatistiksel olarak anlamlı şekilde düşük bulundu (p<0,05). Çalışmamızda literatürde çelişkili sonuçlar bulunan asprosin ve apelin düzeylerinin yüksek olması ve adipokin hormonları arasındaki pozitif korelasyonlar önemli bulgular olarak değerlendirilebilir.

Objective: Obesity is defined as excessive increase in adipose tissue in the body. Adipose tissue also provides the secretion of adipokine hormones such as leptin, adiponectin, asprosin and apelin, which play an important role in metabolism and energy homeostasis. For this reason, changes in the levels of these adipokine hormones secreted from the adipose tissue, not the increase in adipose tissue alone, are effective in determining childhood obesity and explaining the pathological mechanisms. Evaluation of these polypeptides will be effective in the diagnosis of obesity and elucidating the pathological mechanisms associated with obesity. Material and Method: In our study, it was conducted to reveal the relationship of obese children with some markers of obesity such as serum leptin, adiponectin, asprosin and apelin levels, and blood lipids, fasting blood glucose and insulin resistance index (HOMA-IR) values. 105 obese children and 38 normal weight children participated in our study. The demographic information of the children was determined by the face-to-face survey method. Leptin, adiponectin, asprosin and apelin levels were determined in morning fasting blood samples from obese and normal weight children with the help of commercial Elisa kit. Result and Discussion: Leptin and adiponectin levels were not different in obese and normal weight children (p>0.05). Asprosin and apelin levels were found to be significantly higher in obese children compared to normal weight children (p<0.001). Positive correlations were observed between adipokine hormones in both obese and normal children. The ratios of leptin/asprosin, leptin/apelin, adiponectin/asprosin, adiponectin/apelin, asprosin/apelin were found to be statistically significantly lower in obese children when compared with normal weight children (p<0.05). In our study, high levels of asprosin and apelin, which have conflicting results in the literature, and positive correlations between adipokine hormones can be considered as important findings.

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