Technological developments, which have gained great momentum in recent years, have profoundly affected the field of health services and paved the way for the widespread use of minimally invasive techniques such as laparoscopic interventions, especially in the surgical field. Laparoscopic surgery has gained an important place among modern surgical applications with the development of minimally invasive methods. However, this technological transformation in healthcare has not only brought innovations but also some structural and operational challenges. Laparoscopic surgery creates significant physical strain and cognitive stress on operating room nurses due to limited intraoperative field of view, limited motor range of motion, high level of equipment density and ergonomic limitations due to static working positions. The cables and connection systems used in laparoscopic interventions increase the risks of frequent falls, entrapment, and contamination of the sterile field; they also complicate the coordination of the surgical team. In addition to these situations, the rapid technological advances in the field of surgery and the integration of advanced devices bring about the need for continuous professional development and technological adaptation of operating room nurses. In this review study, the main challenges faced by operating room nurses during laparoscopic surgery are discussed in the light of the literature; modern technology-based solutions such as simulation-based trainings, ergonomic arrangements, artificial intelligence-based planning systems and cable management solutions are included. Therefore, in order to make laparoscopic surgery processes safer, more efficient and sustainable, innovative and holistic approaches need to be developed to manage the difficulties experienced by operating room nurses.