The association between diabetes mellitus and functionality in knee osteoarthritis: a cross-sectional study

Abstract

Objective: The aim of this study was to determine the roles of diabetes mellitus (DM) on quality of life, function of knee, and muscle strength in patients with knee osteoarthritis (OA). Material and Method: This single-center, case-control study prospectively enrolled outpatients with knee OA visiting a physical therapy and rehabilitation clinic. The patients were grouped according to the presence of DM diagnosis. Demographic data, disease duration, and medical treatments of patients were recorded. Clinical parameters, radiographic grading (Kellgren-Lawrence grades), functional scales of the knee and quality of life were evaluated. Results: The study included 82 participants [age: 61.3±6.7 years; female: 76.8%]. The mean Western Ontario and McMaster Universities Osteoarthritis Index of OA patients with (n=37) and without DM (n=45) were 45.79±18.04 vs. 65.94±16.23, respectively (p=0.003). The Hb A1c levels showed a negative correlation with Knee Injury and Osteoarthritis Outcome Score components (pain, quality of life, sports, daily activities, symptom duration) (p<0.001, r:-0.440; p<0.001, r:-0.393; p<0.001, r:-0.396; p<0.001, r:-0.336; p:0.002, r:-0.342, respectively) and also, a negative correlation with knee flexion degree (p<0.001, r:-0.401). Conclusion: DM has a negative effect on quality of life and activities of life in knee OA.

Keywords

• Osteoarthritis
• diabetes
• functionality
• quality of life

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