Effect of chitosan application on lung tissue in rats with experimental fluorine toxicity

Abstract

Aim: The aim of this study is to investigate the effects of chitosan application on lung tissue in rats with experimental fluorine toxicity. Material and Method: In the study, 21 healthy male wistar albino rats were used. Prior to the trial, the acclimation of the rats was provided. 3 groups were randomly generated in a way that there were 7 rats in each group. These were determined as the control group (C), the fluorosis group (NaF) and the fluorosis + chitosan (NaF+CS) group. Results: In the NaF group, CAT, SOD and GSH values were found to be low compared to other groups and MDA values were found to be high. It was found that the chitosan application reduced the CAT, SOD and GSH values, and increased the MDA value. Conclusion: It has been predicted that chitosan application may be beneficial in preventing cellular damage that may occur with fluorine exposure.

Keywords

• Chitosan
• Sodium fluoride
• Antioxidant
• Lung

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