The relationship between nutrition, inflammation and colchicine resistance in familial Mediterranean fever

Yıl 2022, , 1624 - 1630, 25.10.2022

Tülay Omma , Seda Çolak , Sevinç Can Sandıkçı , Fatmanur Hümeyra Zengin , Ahmet Omma

https://doi.org/10.32322/jhsm.1173363

Öz

Aim: Familial Mediterranean fever (FMF) is an autoinflammatory and genetic disease associated with chronic inflammation. Colchicine is the gold standard treatment for FMF, although some patients respond partially. Factors such as heavy exercise, cold exposure, stress, recent infection or surgery have been associated with the occurrence of attacks. Recently, nutrition is thought to be involved in the pathogenesis of autoimmune and autoinflammatory diseases. Therefore, we aimed to investigate the relationship between nutrition, inflammation and colchicine resistance by considering the nutritional status of FMF patients.
Material and Method: The study included 59 patients and 67 healthy individuals who were matched for gender, age and body mass index (BMI). Clinical, anthropometric, and biochemical measurements were obtained. Three-days, 24-hour diet records were recorded in the nutrient database program (BeBiS software program), the amounts of macro and micronutrient contents were determined and the Diet Inflammatory Index (DII) score was calculated and compared between groups.
Results: Statistically, the diets of FMF patients were found to be higher in omega-6, carbohydrate percentage and salt content, and lower in terms of lactose, fat percentage, monounsaturated fatty acids, retinol and biotin compared to controls. There was no correlation between DII and acute phase reactants and colchicine dose.
Conclusion: The course of FMF can be affected by environmental factors, as well as its genetic background. Nutrition is a new and interesting topic in this regard and may contribute to inflammation and disease activity in FMF patients.

Anahtar Kelimeler

Familial Mediterranean fever, inflammation, nutrition, colchicine resistance, dietary inflammatory index

Destekleyen Kurum

Bulunmuyor

Proje Numarası

-

Teşekkür

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

Kaynakça

• Ozdogan H, Ugurlu S. Familial Mediterranean Fever. Presse Med 2019; 48: 61–76.
• Erer B, Demirkaya E, Ozen S, Kallinich T. What is the best acute phase reactant for familial Mediterranean fever follow-up and its role in the prediction of complications? A systematic review. Rheumatol Int 2016; 36: 483–7.
• Ben-Chetrit E, Aamar S. About colchicine compliance, resistance and virulence. Clin Exp Rheumatol 2009; 27: 1–3.
• Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr 2014; 17: 1689–96.
• Garcia-Arellano A, Ramallal R, Ruiz-Canela M, et al. Predimed Investigators. Dietary Inflammatory Index and Incidence of Cardiovascular Disease in the PREDIMED Study. Nutrients 2015; 7: 4124–38.
• Fowler ME, Akinyemiju TF. Meta-analysis of the association between dietary inflammatory index (DII) and cancer outcomes. Int J Cancer 2017; 141: 2215–27.
• Matsumoto Y, Shivappa N, Sugioka Y, et al. Change in dietary inflammatory index score is associated with control of long-term rheumatoid arthritis disease activity in a Japanese cohort: the TOMORROW study. Arthritis Res Ther 2021; 23: 105.
• Rambod M, Nazarinia M, Raieskarimian F. The impact of dietary habits on the pathogenesis of rheumatoid arthritis: a case-control study. Clin Rheumatol 2018; 37: 2643–48.
• Scrivo R, Perricone C, Altobelli A, et al. Dietary Habits Bursting into the Complex Pathogenesis of Autoimmune Diseases: The Emerging Role of Salt from Experimental and Clinical Studies. Nutrients 2019; 11: 1013.
• Korkmaz C, Ozdogan H, Kasapçopur O, Yazici H. Acute phase response in familial Mediterranean fever. Ann Rheum Dis 2002; 61: 79–81.
• Ebispro for Windows, Stuttgart, Germany; Turkish Version (BeBiS 8.2) (2019) Pasifik Elektirik Elektronik Ltd. Şti. (www.bebis.com.tr); Istanbul
• Faul F, Erdfelder E, Lang AG, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. Behav Res Methods 2007; 39:175-91.
• French FMF Consortium. A candidate gene for familial Mediterranean fever. Nat Genet 1997; 17: 25–31.
• Liston A, Masters SL. Homeostasis-altering molecular processes as mechanisms of inflammasome activation. Nat Rev Immunol 2017; 17: 208–14.
• Hermsdorff HH, Zulet MA, Puchau B, Martínez JA. Fruit and vegetable consumption and proinflammatory gene expression from peripheral blood mononuclear cells in young adults: a translational study. Nutr Metab 2010; 7: 42.
• Agrawal S, Agrawal A, Said HM. Biotin deficiency enhances the inflammatory response of human dendritic cells. Am J Physiol Cell Physiol 2016; 311: 386–91.
• Rodriguez-Melendez R, Schwab LD, Zempleni J. Jurkat cells respond to biotin deficiency with increased nuclear translocation of NF-kappaB, mediating cell survival. International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Int J Vitam Nutr Res 2004; 74: 209–16.
• Kuroishi T, Endo Y, Muramoto K, Sugawara S. Biotin deficiency up-regulates TNF-alpha production in murine macrophages. J Leukoc Biol 2008; 83: 912–20.
• Wiedmann S, Eudy JD, Zempleni J. Biotin supplementation increases expression of genes encoding interferon-gamma, interleukin-1beta, and 3-methylcrotonyl-CoA carboxylase, and decreases expression of the gene encoding interleukin-4 in human peripheral blood mononuclear cells. J Nutr 2003; 133: 716–19.
• Hotamisligil GS, Erbay E. Nutrient sensing and inflammation in metabolic diseases. Nat Rev Immunol 2008; 8: 923–34.
• Mellinkoff SM, Schwabe AD, Lawrence JS. A Dietary Treatment for Familial Mediterranean Fever. Arch Intern Med 1961; 108: 80-5.
• Sohar E, Gafni J, Chaimow M, Prass M, Heller H. Low-Fat Diet in Familial Mediterranean Fever. A Therapeutic Trial. Arch Intern Med 1962; 110: 150-4.
• Hu Y, Block G, Norkus EP, Morrow JD, Dietrich M, Hudes M. Relations of glycemic index and glycemic load with plasma oxidative stress markers. Am J Clin Nutr 2006; 84: 70–6.
• Dickinson S, Hancock DP, Petocz P, Ceriello A, Brand-Miller J. High-glycemic index carbohydrate increases nuclear factor-kappaB activation in mononuclear cells of young, lean healthy subjects. Am J Clin Nutr 2008; 87: 1188–93.
• Ma Y, Hébert JR, Li W, et al. Association between dietary fiber and markers of systemic inflammation in the Women's Health Initiative Observational Study. Nutrition 2008; 24: 941–9.
• Casas R, Estruch R, Sacanella E. The Protective Effects of Extra Virgin Olive Oil on Immune-mediated Inflammatory Responses. Endocr Metab Immune Disord Drug Targets 2018; 18: 23–35.
• Innes JK, Calder PC. Omega-6 fatty acids and inflammation. Prostaglandins Leukot Essent Fatty Acids 2018; 132: 41–8.
• Bordoni A, Danesi F, Dardevet D, et al. Dairy products and inflammation: A review of the clinical evidence. Crit Rev Food Sci Nutr 2017; 57: 2497–2525.
• Labonté MÈ, Couture P, Richard C, Desroches S, Lamarche B. Impact of dairy products on biomarkers of inflammation: a systematic review of randomized controlled nutritional intervention studies in overweight and obese adults. Am J Clin Nutr 2013; 97: 706–17.
• Tsai YT, Cheng PC, Pan T M. The immunomodulatory effects of lactic acid bacteria for improving immune functions and benefits. Appl Microbiol Biotechnol 2012; 96: 853–62.
• Tanumihardjo SA, Russell RM, Stephensen CB, et al. Biomarkers of Nutrition for Development (BOND)-Vitamin A Review. J Nutr 2016; 146: 1816S–48S.
• Barbaro NR, Foss JD, Kryshtal DO, et al. Dendritic Cell Amiloride-Sensitive Channels Mediate Sodium-Induced Inflammation and Hypertension. Cell Rep 2017; 21: 1009–20.
• Binger KJ, Gebhardt M, Heinig M, et al. High salt reduces the activation of IL-4- and IL-13-stimulated macrophages. J Clin Invest 2015; 125: 4223–38.
• Ip WK, Medzhitov R. Macrophages monitor tissue osmolarity and induce inflammatory response through NLRP3 and NLRC4 inflammasome activation. Nat Commun 2015; 6: 6931.