Predictive importance of systemic inflammation response index in de novo brain metastatic small cell lung cancer patients

Abstract

Aims: The subtype of lung cancer, known as small cell lung cancer (SCLC), tends to have a highly fatal course, especially in advanced stages. In particular, the overall survival durations further decrease in cases of brain metastases in SCLC. There is increasing evidence for the role of systemic inflammation parameters in predicting cancer prognosis, and they appear likely to become potential target markers for clinical treatments in the future. We aimed to evaluate the systemic inflammation response index (SIRI), a novel inflammatory laboratory marker that could predict long-term survival and serve as a potential target marker for clinical treatment, in patients with de novo brain metastatic small cell lung carcinoma (DNBM SCLC)." Methods: Clinicopathological features of adult patients diagnosed with DNBM SCLC were recorded from the patient registry of the hospital. Patients without medical records were not included in the study. Investigations were carried out to assess the prognostic effect of the SIRI parameter in predicting the 12-month overall survival (OS12) in DNBM SCLC patients, by determining a cut-off value and conducting appropriate statistical analyses, considering p-values (<0.05) as statistically significant. Results: In this study 256 SCLC patients screened from the hospital database and detected 42 patients with de novo brain metastases (DNBM) were included in the study.The median age of patients was 61; 85.7% of the sample was male while 14.3% was female. When the SIRI marker was 1.79 or below, OS12 in patients was statistically significantly better predicted than in those with values above 1.79 (Cut off ≤ 1.79 AUC: 0.751, sensitivity: 66.7%, specificity: 66.7%; p=0.022). Also, SIRI ≤ 1.79 was found to be an independent variable predicting OS12 in DNBM SCLC patients. Conclusion: Our study is important in terms of the short overall survival durations observed in DNBM SCLC patients and the identification of conventional laboratory parameters that can be used to predict longer survival durations in these patients.

Keywords

• small cell lung cancer
• systemic inflammation
• 12-month overall survival
• brain metastasis

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