The diagnostic weight of hemogram parameters in diagnosis, severity, and disease duration of childhood atopic dermatitis: a thorough evidence-focused study

Abstract

Aims: We aimed to assess the association of hemogram parameters with atopic dermatitis (AD), severity of AD, and disease duration. Methods: We included the hemogram parameters of patients under follow-up in our pediatric allergy outpatient clinic and healthy group. The blood samples were drawn when they had no complaints or after at least 30 days of infection or a drug-free period. We built H1 and H0 (null) hypotheses, subjected data to Bayesian statistics, and assessed which hemogram parameters have potential and which shall not be used, with presenting evidence levels. We split the transactions into two groups (<49 and ≥49 months old) as there is a lymphocyte predominancy before four years of age and built another model with all individuals. Results: We included 197 AD-diagnosed patients and 150 controls in the study. Eosinophil was the significant confounder for AD, and White Blood Cell Count, Absolute Neutrophil Count, Platelet Count, and Red Cell Distribution Width (RDW)/Platelet Ratio were independent of AD. Eosinophil/Lymphocyte Ratio (ELR) was correlated with SCORAD index (anecdotal evidence) under four years old, ELR and total IgE in older four years old, and ELR and Eosinophil/Neutrophil Ratio in all age groups. None of the hemogram parameters were correlated with disease duration in our under-4-year-old patient group. However, there was anecdotal evidence for RDW correlation with disease duration in the older four years group. Age, Neutrophil/ Lymphocyte Ratio, and Platelet/Lymphocyte Ratio had a strong association with disease duration. Conclusion: We presented which hemogram parameter could be used and should not be used in children for AD diagnosis and AD follow-up. Multicenter studies are needed for the final conclusion.

Keywords

• Atopic dermatitis
• Hemogram
• Parameters
• Children

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