Akut koroner sendromlu hastalarda nötrofil yüzdesi/albumin oranı ile infakrt ilişkili arter açıklığı arasındaki ilişki

Abstract

Giriş: Dünya genelinde ölüm ve hastalık yükünün önde gelen nedenlerinden biri koroner kalp hastalığıdır (KKH). AKS'nin birincil nedeni aterosklerotik plak rüptürü ve trombüs gelişimidir. AKS hastalarının prognozu ayrıca aterosklerotik plaklar, enflamatuar hücre infiltrasyonu (lenfositler, monositler ve nötrofiller) ve enflamasyon göstergeleri ile bağlantılıdır. Daha önceki araştırmalarda düşük serum albümin düzeyleri AKS hastalarında ölümle ilişkilendirilmiştir. Çalışmamızda, NPAR'ın infarktla ilişkili advers kardiyak olaylar (MACE) ve infarktla ilişkili koroner arter açıklığı (IRA) ile ilişkisini araştırmayı amaçladık. Yöntem: NPAR oranı, xxx Eğitim ve Araştırma Hastanesi'ne AKS ile başvuran ve koroner anjiyografi (KAG) yapılan hastaların başvuru sırasında veri sisteminde kayıtlı olan geçmiş laboratuvar bulgularına dayanarak hesaplandı. Çalışmaya toplam 87 hasta dahil edilmiştir. Bu hastaların 62'si (%71) patent olmayan ve 25'i (%29) patent IRA hastasıydı. Sonuçlar: NPAR patenti olmayan grupta anlamlı olarak daha yüksekti (19.223.14 ve 17.142.78 p=0.004). Çok değişkenli lojistik regresyon analizinde, NPAR (p= 0.027, Odds Oranı (OR): 0.787, %95 Güven Aralığı CIs: 0.637-0.974) düzeylerinin patent IRA'nın bağımsız öngördürücüleri olduğu bulunmuştur.

Keywords

• nötrofil
• albümin
• enfarkt ilişkili arter
• akut koroner sendrom

The relationship between neutrophil percentage-to-albumin ratio and infarct related artery patency in patients with acute coronary syndrome

Abstract

Aims: One of the leading causes of death and disease burden globally is coronary heart disease (CHD). The primary cause of acute coronary syndrome (ACS) is atherosclerotic plaque rupture and thrombus development. The prognosis of ACS patients is also linked to atherosclerotic plaques, inflammatory cell infiltration (lymphocytes, monocytes, and neutrophils), and inflammation indicators. Low serum albumin (SA) levels have been linked to death in ACS patients in earlier research. In our study, we aimed to investigate the association of neutrophil percentage-to-albumin ratio (NPAR) with infarct-related adverse cardiac events (MACE) and infarct-related coronary artery patency (IRA). Methods: The NPAR ratio was calculated based on the past laboratory findings of patients admitted with ACS who underwent coronary angiography (CAG), which were registered in the data system at the time of admission. A total of 87 patients were included in the study. Of these patients, 62 (71%) were non-patent and 25 (29%) were patent IRA patients. Results: NPAR was significantly higher in the non-patent group (19.22±3.14 and 17.14±2.78 p=0.004). In multivariable logistic regression analysis, NPAR [p=0.027, odds ratio (OR): 0.787, 95% confidence intervals (CIs): 0.637-0.974] levels were found to be independent predictors of patent IRA. As revealed by the ROC curve analysis, the cut-off value of 17.88 for NPAR predicted the non-patent IRA with a sensitivity of 64% and specificity of 64% (AUC: 0.681; CIs: 0.588-0.809; p=0.008) NPAR was significantly higher in the MACE group (22.83±3.85 and 17.95±2.49 p<0.001). Conclusion: In conclusion, inflammatory markers have been and are being used as predictive parameters for cardiovascular diseases in many studies. In our study, we focused on neutrophils and albumin. These findings revealed that NPAR is a independent predictor of IRA patency and long term mortality. We also indicated that NPAR may have a predictive role for mortality in the long-term follow-up of ACS patients.

Keywords

• Neutrophil
• albumin
• infarct related artery
• acute coronary syndrome

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