Alkaptonurik ocronosisde total diz artroplastisi: bir vaka raporu

Year 2026, Volume: 9 Issue: 1, 253 - 255, 05.01.2026

Bedrettin Akar , Yusuf Öztürkmen , Mehmet Bülent Balıoğlu , Murat Erkek , Selim Harmanşa

https://doi.org/10.32322/jhsm.1786236

https://izlik.org/JA57YK83RD

Abstract

Olgu: Her iki dizde ağrı ve fonksiyonel kısıtlılık şikayetiyle hastanemize başvuran 65 yaşında erkek hasta; preop Alkaptonuri teşhisi konmadan klasik Kellgren-Lawrence sınıflamasına göre grade IV osteoartroz olarak değerlendirilerek total diz artroplasti tedavisi uygulanmıştır. Alkaptonuri teşhisi cerrahi sırasında alınan biopsi materyalerinin incelenmesi ile post op dönemde konulmuştur. Alkaptonüri, yavaş ilerlemesi nedeniyle genellikle geç teşhis edilir. Büyük eklem artriti ile başvuran genç hastalarda, ocronozis tanısı için şüphelenilmelidir.İleri düzey ocronotik artrozda, total eklem replasman tedavisi ile başarılı sonuçlar alınabilmektedir.

Keywords

Alkaptonüri , Homogentisik asit oksidaz , Osteoartroz , Diz Replasmanı , Artroplasti

Total knee arthroplasty in alkaptonuric ochronosis: a case report

https://izlik.org/JA57YK83RD

Abstract

A 65-year-old male patient presented to our hospital with complaints of bilateral knee pain and functional limitation. Without a preoperative diagnosis of alkaptonuria, the patient was evaluated as grade IV osteoarthrosis according to the classical Kellgren Lawrence classification, and total knee arthroplasty was performed. The diagnosis of alkaptonuria was established in the postoperative period by examination of biopsy materials obtained during surgery. Alkaptonuria is generally diagnosed late due to its slow progression. In young patients presenting with large joint arthritis, ochronosis should be suspected as a possible diagnosis. In advanced ochronotic arthrosis, successful outcomes can be achieved with total joint replacement therapy.

Keywords

Alkaptonuria , homogentisic acid oxidase , osteoarthrosis , knee replacement , arthroplasty

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