Behçet hastalığı olan kadınlarda gebelik sonuçları

Abstract

Amaçlar: Son 30 yılda yayınlanmış olgu sunumlarının birleştirilmiş analizine dayanarak, Behçet hastalığı (BH) ile komplike gebeliklerin maternal ve neonatal sonuçlarını tanımlamak. Yöntemler: Ocak 1995 ile Mart 2025 arasında yayınlanmış gebelikte BH olgu sunumlarını ve olgu serilerini belirlemek için PubMed, Web of Science Core Collection ve Google Akademik'te sistematik bir arama yapıldı. Anne yaşı, hastalık süresi, hastalık aktivitesi, doğum sonuçları ve yenidoğan doğum ağırlığına ilişkin veriler çıkarıldı. Bulgular: Toplam 61 olgu tespit edildi. Ortalama anne yaşı 32,3 ± 6,3 yıl ve ortalama hastalık süresi 5,2 ± 3,2 yıldı. Gebelik sırasında alevlenmeler kadınların %32,8'inde bildirildi. Preterm doğum (%11,5) ve düşük doğum ağırlığı (%11,5) en sık görülen komplikasyonlar iken, düşük (%3,3) ve preeklampsi (%1,6) daha az sıklıkta görüldü. Ortalama yenidoğan doğum ağırlığı 3045 ± 517 g olarak bulundu. Sonuç: Bu birleşik analizde, erken doğum ve düşük doğum ağırlığı, Behçet Hastalığı (BH) olan gebeliklerde en sık görülen komplikasyonlardı. Kadın doğum uzmanları, Behçet Hastalığı'nın (BH) ilk olarak gebelik sırasında ortaya çıkabileceğinin farkında olmalı ve özellikle yüksek prevalanslı bölgelerde etkilenen kadınları yakından takip etmelidir.

Keywords

• Behçet hastalığı
• gebelik
• erken doğum
• düşük doğum ağırlığı
• vaskülit

Supporting Institution

Yazar bu çalışmanın herhangi bir finansal destek almadığını beyan etmiştir.

Ethical Statement

Uygun değildir, çünkü bu çalışma yayınlanmış vaka raporlarının incelenmesine dayanmaktadır ve doğrudan hasta alımını içermemektedir.

Thanks

Yazar, dolaylı olarak katkıda bulunan tüm meslektaşlarına teşekkür eder.

Pregnancy outcomes in women with Behçet’s disease

Abstract

Aims: To describe maternal and neonatal outcomes of pregnancies complicated by Behçet’s disease (BD) based on a pooled analysis of published case reports over the past 30 years. Methods: A systematic search of PubMed, Web of Science Core Collection, and Google Scholar was performed to identify case reports and case series of BD in pregnancy published between January 1995 and March 2025. Data on maternal age, disease duration, disease activity, delivery outcomes, and neonatal birth weight were extracted. Results: A total of 61 cases were identified. The mean maternal age was 32.3±6.3 years, and the mean disease duration was 5.2±3.2 years. Flares during pregnancy were reported in 32.8% of women. Preterm delivery (11.5%) and low birth weight (11.5%) were the most common complications, while miscarriage (3.3%) and preeclampsia (1.6%) were less frequent. The mean neonatal birth weight was 3045±517 g. Conclusion: In this pooled analysis, preterm delivery and low birth weight were the most frequent complications among pregnancies with BD. Obstetricians should be aware that BD may first present during pregnancy and should closely monitor affected women, especially in high-prevalence regions.

Keywords

• Behçet’s disease
• pregnancy
• preterm birth
• low birth weight
• vasculitis

Supporting Institution

The author declared that this study has received no finnacial support.

Ethical Statement

Not applicable, as this study is based on a review of published case reports and did not involve direct patient recruitment.

Thanks

The author thanks all colleagues who contributed indirectly.

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