Çoklu HPV DNA pozitifliğinin kolposkopik biyopsi sonuçları ile ilişkisi

Year 2026, Volume: 9 Issue: 2, 365 - 369, 12.03.2026

Dilek Buldum , Şefik Eser Özyürek , Önder Aydın , Nurşen Kurtoğlu

https://izlik.org/JA83WG22ML

Abstract

Amaç: Bu çalışmada çoklu HPV DNA pozitifliklerinin servikal yüksek dereceli lezyonlarla veya servikal kanserle ilişkisinin araştırılması amaçlanmıştır.
Gereçler ve Yöntem: Kadın Hastalıkları ve Doğum Kliniği’nde kolposkopik biyopsi uygulanmış 164 hastanın medikal kayıtları retrospektif olarak analiz edilerek, PAP smear sonucu: (LGSIL - ASCUS - ASC-H)-HPV testi (pozitif) - HPV alt tiplemeleri incelenmiştir. Olgular ; Grup I (negatif, LSIL, koilositoz ve CIN I) ve Grup II (HSIL, CIN II-III, skuamöz karsinom) olmak üzere 2 gruba ayrılmıştır.
Bulgular: Çalışma sonucunda hastaların bazı demografik özellikleri (yaş, parite, menstruasyon durumu), çoklu veya tekli HPV alt tipleri açısından pozitif olma durumları ile kolposkopik biyopsi sonuçları arasında istatistiksel olarak anlamlı fark saptanmamıştır.
Sonuç: Çoklu HPV enfeksiyonlarının servikal displazi ve kanser üzerindeki etkisini aydınlatmak için daha büyük kohortları içeren çalışmalara ihtiyaç vardır.
Anahtar Kelimeler: Çoklu HPV enfeksiyonu, Rahim ağzı kanseri, İnsan papilloma virüsü, Tarama
Kısaltmalar: HPV, Human papilloma virus; PAP, Papanicolaous; CIN, Cervical intraepithelial neoplasms; LSIL, Low grade squamous intraepithelial lesion; HSIL, High grade squamous intraepithelial lesion; ASCUS, Atypical squamous cell of undetermined significance; ASC-H, Atypical squamous cell- cannot exclude HSIL

Keywords

çoklu hpv enfeksiyonu , servikal kanser , insan papillomavirüs , tarama

Ethical Statement

Çalışmanın etik izni 2017-597 proje numarası ve 17.08.2017 tarihi ile alınmıştır.

Supporting Institution

Bu çalışma herhangi bir kurum tarafından desteklenmemiştir.

Project Number

2017-597

Thanks

Çalışma süreci boyunca veri toplama aşamasına destek veren tüm klinik personeline teşekkürlerimizi sunarız. Bu makalenin bazı bölümleri, yalnızca dil açıklığını, yazım kurallarını ve tutarlılığı artırmak amacıyla yapay zekâ tabanlı araçlar kullanılarak düzenlenmiştir. Tüm bilimsel içerik, veri yorumları ve sonuçlar tamamen araştırmacılar tarafından oluşturulmuş, doğrulanmış ve onaylanmıştır.

The relationship of multiple HPV DNA positivity with colposcopic biopsy results

https://izlik.org/JA83WG22ML

Abstract

Aims: This study aimed to investigate the association between multiple HPV DNA positivity and the presence of high-grade cervical intraepithelial lesions or cervical cancer.
Methods: The medical records of 164 patients who underwent colposcopic biopsy in the department of obstetrics and gynecology were retrospectively reviewed. PAP smear results (LGSIL, ASCUS, ASC-H), HPV test positivity, and HPV genotypes were evaluated. Based on colposcopic biopsy findings, patients were categorized into two groups: group I: negative, LSIL, koilocytosis, and CIN I; group II: HSIL, CIN II–III, and squamous cell carcinoma.
Results: No statistically significant association was found between the presence of multiple HPV genotypes, single HPV genotype positivity, and colposcopic biopsy outcomes. Additionally, demographic factors such as age, parity, and menstrual status were not associated with high-grade cervical lesion development.
Conclusion: The present study does not provide evidence that multiple HPV infections increase the risk of cervical dysplasia or cervical cancer. Larger, prospective studies are needed to better clarify the clinical impact of multiple HPV infections.

Keywords

Multiple HPV infection , cervical cancer , human papillomavirus , screening

Ethical Statement

Ethical approval for the study was obtained under project number 2017-597 on 17.08.2017.

Supporting Institution

This study received no financial support from any institution.

Project Number

2017-597

Thanks

The authors would like to thank all clinical staff who supported data collection during the study process. Portions of the manuscript benefited from the use of artificial intelligence–based tools solely for improving language clarity, grammar, and consistency; all scientific content, data interpretation, and conclusions were fully authored and approved by the researchers.

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