Review

Effects of exercise-induced myokines on rehabilitation and metabolic regulation

Volume: 9 Number: 3 May 19, 2026

Effects of exercise-induced myokines on rehabilitation and metabolic regulation

Abstract

Recent research on exercise has introduced a new biological dimension by demonstrating that skeletal muscle functions not only as a mechanical structure but also as an endocrine organ. Myokines released from skeletal muscle during exercise play critical roles in metabolic regulation, inflammation control, nervous system function, and tissue regeneration. Consequently, growing research interest has focused on elucidating the biological and therapeutic significance of myokines. This review examines the effects of exercise-induced myokines on clinical rehabilitation and metabolic regulation, highlighting their therapeutic potential in neurological and cardiac rehabilitation as well as in the management of metabolic syndrome, while emphasizing the biological properties and functional roles of the most extensively studied myokines.

Keywords

References

  1. Barbalho SM, Flato UAP, Tofano RJ, et al. Physical exercise and myokines: relationships with sarcopenia and cardiovascular complications. Int J Mol Sci. 2020;21(10):3607. doi:10.3390/ijms21103607
  2. Qi C, Song X, Wang H, Yan Y, Liu B. The role of exercise-induced myokines in promoting angiogenesis. Front Physiol. 2022;13:981577. doi:10.3389/fphys.2022.981577
  3. Severinsen MCK, Pedersen BK. Muscle–organ crosstalk: the emerging roles of myokines. Endocr Rev. 2020;41(4):594-609. doi:10.1210/endrev/bnaa016
  4. Iglesias P. Muscle in endocrinology: from skeletal muscle hormone regulation to myokine secretion and its implications in endocrine-metabolic diseases. J Clin Med. 2025;14(13):4490. doi:10.3390/jcm1413 4490
  5. Zhu M, Chen W, Zhang J. Aerobic exercise, an effective intervention for cognitive impairment after ischemic stroke. Front Aging Neurosci. 2025; 17:1514271. doi:10.3389/fnagi.2025.1514271
  6. De Assis GG, Murawska-Ciałowicz E. Brain-derived neurotrophic factor and stroke: perspectives on exercise as a health care strategy. Hum Mov. 2024;25(1):1-14. doi:10.5114/hm.2024.136050
  7. Jodeiri Farshbaf M, Alviña K. Multiple roles in neuroprotection for the exercise-derived myokine irisin. Front Aging Neurosci. 2021;13:649929. doi:10.3389/fnagi.2021.649929
  8. Villamil-Parra W, Moscoso-Loaiza L. Effects of physical exercise on irisin and BDNF concentrations, and their relationship with cardiometabolic and mental health of individuals with metabolic syndrome: a systematic review. Exp Gerontol. 2024;198:112640. doi:10.1016/j.exger.2024.112640

Details

Primary Language

English

Subjects

Clinical Chemistry

Journal Section

Review

Publication Date

May 19, 2026

Submission Date

February 5, 2026

Acceptance Date

April 17, 2026

Published in Issue

Year 2026 Volume: 9 Number: 3

APA
Öztürk, E. Z., & Alataş, M. (2026). Effects of exercise-induced myokines on rehabilitation and metabolic regulation. Journal of Health Sciences and Medicine, 9(3), 846-851. https://doi.org/10.32322/jhsm.1883007
AMA
1.Öztürk EZ, Alataş M. Effects of exercise-induced myokines on rehabilitation and metabolic regulation. J Health Sci Med / JHSM. 2026;9(3):846-851. doi:10.32322/jhsm.1883007
Chicago
Öztürk, Elif Zeynep, and Mehlika Alataş. 2026. “Effects of Exercise-Induced Myokines on Rehabilitation and Metabolic Regulation”. Journal of Health Sciences and Medicine 9 (3): 846-51. https://doi.org/10.32322/jhsm.1883007.
EndNote
Öztürk EZ, Alataş M (May 1, 2026) Effects of exercise-induced myokines on rehabilitation and metabolic regulation. Journal of Health Sciences and Medicine 9 3 846–851.
IEEE
[1]E. Z. Öztürk and M. Alataş, “Effects of exercise-induced myokines on rehabilitation and metabolic regulation”, J Health Sci Med / JHSM, vol. 9, no. 3, pp. 846–851, May 2026, doi: 10.32322/jhsm.1883007.
ISNAD
Öztürk, Elif Zeynep - Alataş, Mehlika. “Effects of Exercise-Induced Myokines on Rehabilitation and Metabolic Regulation”. Journal of Health Sciences and Medicine 9/3 (May 1, 2026): 846-851. https://doi.org/10.32322/jhsm.1883007.
JAMA
1.Öztürk EZ, Alataş M. Effects of exercise-induced myokines on rehabilitation and metabolic regulation. J Health Sci Med / JHSM. 2026;9:846–851.
MLA
Öztürk, Elif Zeynep, and Mehlika Alataş. “Effects of Exercise-Induced Myokines on Rehabilitation and Metabolic Regulation”. Journal of Health Sciences and Medicine, vol. 9, no. 3, May 2026, pp. 846-51, doi:10.32322/jhsm.1883007.
Vancouver
1.Elif Zeynep Öztürk, Mehlika Alataş. Effects of exercise-induced myokines on rehabilitation and metabolic regulation. J Health Sci Med / JHSM. 2026 May 1;9(3):846-51. doi:10.32322/jhsm.1883007

Interuniversity Board (UAK) Equivalency: Article published in Ulakbim TR Index journal [10 POINTS], and Article published in other (excuding 1a, b, c) international indexed journal (1d) [5 POINTS].

The Directories (indexes) and Platforms we are included in are at the bottom of the page.

Note: Our journal is not WOS indexed and therefore is not classified as Q.

You can download Council of Higher Education (CoHG) [Yüksek Öğretim Kurumu (YÖK)] Criteria) decisions about predatory/questionable journals and the author's clarification text and journal charge policy from your browser. https://dergipark.org.tr/tr/journal/2316/file/4905/show







The indexes of the journal are ULAKBİM TR Dizin, ICI World of Journals, DOAJ, Directory of Research Journals Indexing (DRJI), General Impact Factor, ASOS Index, WorldCat (OCLC), MIAR, OpenAIRE, Türkiye Citation Index, Türk Medline Index, InfoBase Index, Scilit, etc.

       images?q=tbn:ANd9GcRB9r6zRLDl0Pz7om2DQkiTQXqDtuq64Eb1Qg&usqp=CAU

500px-WorldCat_logo.svg.png

atifdizini.png

logo_world_of_journals_no_margin.png

images?q=tbn%3AANd9GcTNpvUjQ4Ffc6uQBqMQrqYMR53c7bRqD9rohCINkko0Y1a_hPSn&usqp=CAU

doaj.png  

images?q=tbn:ANd9GcSpOQFsFv3RdX0lIQJC3SwkFIA-CceHin_ujli_JrqBy3A32A_Tx_oMoIZn96EcrpLwTQg&usqp=CAU

ici2.png

asos-index.png

drji.png





The platforms of the journal are Google Scholar, CrossRef (DOI), ResearchBib, Open Access, COPE, ICMJE, NCBI, ORCID, Creative Commons, etc.

COPE-logo-300x199.jpgimages?q=tbn:ANd9GcQR6_qdgvxMP9owgnYzJ1M6CS_XzR_d7orTjA&usqp=CAU

icmje_1_orig.png

cc.logo.large.png

ncbi.pngimages?q=tbn:ANd9GcRBcJw8ia8S9TI4Fun5vj3HPzEcEKIvF_jtnw&usqp=CAU

ORCID_logo.png

1*mvsP194Golg0Dmo2rjJ-oQ.jpeg


Our Journal using the DergiPark system indexed are;

Ulakbim TR Dizin,  Index Copernicus, ICI World of JournalsDirectory of Research Journals Indexing (DRJI), General Impact FactorASOS Index, OpenAIRE, MIAR,  EuroPub, WorldCat (OCLC)DOAJ,  Türkiye Citation Index, Türk Medline Index, InfoBase Index


Our Journal using the DergiPark system platforms are;

Google, Google Scholar, CrossRef (DOI), ResearchBib, ICJME, COPE, NCBI, ORCID, Creative Commons, Open Access, and etc.


Journal articles are evaluated as "Double-Blind Peer Review". 

Our journal has adopted the Open Access Policy and articles in JHSM are Open Access and fully comply with Open Access instructions. All articles in the system can be accessed and read without a journal user.  https//dergipark.org.tr/tr/pub/jhsm/page/9535

Journal charge policy   https://dergipark.org.tr/tr/pub/jhsm/page/10912

Our journal has been indexed in DOAJ as of May 18, 2020.

Our journal has been indexed in TR-Dizin as of March 12, 2021.


17873

Articles published in Journal of Health Sciences and Medicine have open access and are licensed under the Creative Commons CC BY-NC-ND 4.0 International License.