Research Article

Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis

Volume: 9 Number: 4 July 20, 2026
Journal of Health Sciences and Medicine Cover
Journal of Health Sciences and Medicine
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Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis

Abstract

Aims: This study aimed to evaluate laboratory findings in patients with brucellosis in our region where livestock farming is widespread and to examine their contribution in diagnosis. Methods: 254 patients who presented to our hospital’s infectious diseases outpatient clinic with various complaints between 2017 and 2021, tested positive standard tube agglutination (STA), were included in the study. Patients were divided into two groups based on their STA titers: low titers (1/80 and 1/160) and high titers (≥1/320). These two groups were compared regarding demographic data, laboratory data, and symptoms at presentation. Results: According to STA titer, 93 patients (36.6%) had low titers, while 161 patients (63.4%) had high titers. The most common complaints were low back pain and with no significant difference between the two groups. The mean C-reactive protein (CRP) value was higher in the low titer group than in the high titer group, and a significant difference was found between the two groups. Erythrocyte sedimentation rate (ESR), neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) values were slightly higher in the low titer group than in the high titer group, but this difference was not statistically significant. Conclusion: Our study found that laboratory parameters such as CRP, ESR, NLR, and PLR were higher in patients with low titers compared to those with high titers, but significant difference was found only in CRP. Therefore, we believe that in addition to the STA test used in the diagnosis of brucellosis, other laboratory parameters can also assist the clinician in diagnosis.

Keywords

Supporting Institution

There is no supporting institution

Project Number

There is no project number

Ethical Statement

Approval for this study was obtained from Balikesir University School of Medicine, Ethics Committee for Clinical Investigations (Decision Number 2023/02, Date: January 04, 2023).

Thanks

There is no thanks

References

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  4. Zheng R, Xie S, Lu X, et al. A systematic review and meta-analysis of epidemiology and clinical manifestations of human brucellosis in China. Biomed Res Int. 2018;2018:5712920. doi:10.1155/2018/5712920
  5. Yagupsky P, Morata P, Colmenero JD. Laboratory diagnosis of human brucellosis. Clin Microbiol Rev. 2019;33(1):00073-19. doi:10.1128/CMR.00073-19
  6. Nik Mazlan SA, Abdul Hadi Sabri FS, Mohamed Zahidi J, Seman Z, Ahmad N, Ramli SR. Human brucellosis: six years retrospective study on seropositivity in Malaysia. Malays J Pathol. 2022;44(2):269-276.
  7. Balin SO, Tartar AS, Akbulut A. The predictive role of haematological parameters in the diagnosis of osteoarticular brucellosis. Afri Health Sci. 2018;18(4):988-994. doi:10.4314/ahs.v18i4.19
  8. Bozdemir SE, Altintop YA, Uytun S. Diagnostic role of mean platelet volume and neutrophil to lymphocyte ratio in childhood brucellosis. Korean J Intern Med. 2017;32(6):1075-1081. doi:10.3904/kjim.2016.092

Details

Primary Language

English

Subjects

Medical Infection Agents

Journal Section

Research Article

Authors

Publication Date

July 20, 2026

Submission Date

March 2, 2026

Acceptance Date

June 3, 2026

Published in Issue

Year 2026 Volume: 9 Number: 4

IZ

https://izlik.org/JA87FL45TZ

Cite

RIS / Bibtex
APA
Duran, H., Çeken, N., Kula Atik, T., & Yeniiz, E. (2026). Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis. Journal of Health Sciences and Medicine, 9(4), 933-937. https://izlik.org/JA87FL45TZ
AMA
1.Duran H, Çeken N, Kula Atik T, Yeniiz E. Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis. J Health Sci Med / JHSM. 2026;9(4):933-937. https://izlik.org/JA87FL45TZ
Chicago
Duran, Hülya, Nihan Çeken, Tuğba Kula Atik, and Esma Yeniiz. 2026. “Contribution of Laboratory Data to Diagnosis and Treatment in Patients With Brucellosis: A 5-Year Cross-Sectional Analysis”. Journal of Health Sciences and Medicine 9 (4): 933-37. https://izlik.org/JA87FL45TZ.
EndNote
Duran H, Çeken N, Kula Atik T, Yeniiz E (July 1, 2026) Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis. Journal of Health Sciences and Medicine 9 4 933–937.
IEEE
[1]H. Duran, N. Çeken, T. Kula Atik, and E. Yeniiz, “Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis”, J Health Sci Med / JHSM, vol. 9, no. 4, pp. 933–937, July 2026, [Online]. Available: https://izlik.org/JA87FL45TZ
ISNAD
Duran, Hülya - Çeken, Nihan - Kula Atik, Tuğba - Yeniiz, Esma. “Contribution of Laboratory Data to Diagnosis and Treatment in Patients With Brucellosis: A 5-Year Cross-Sectional Analysis”. Journal of Health Sciences and Medicine 9/4 (July 1, 2026): 933-937. https://izlik.org/JA87FL45TZ.
JAMA
1.Duran H, Çeken N, Kula Atik T, Yeniiz E. Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis. J Health Sci Med / JHSM. 2026;9:933–937.
MLA
Duran, Hülya, et al. “Contribution of Laboratory Data to Diagnosis and Treatment in Patients With Brucellosis: A 5-Year Cross-Sectional Analysis”. Journal of Health Sciences and Medicine, vol. 9, no. 4, July 2026, pp. 933-7, https://izlik.org/JA87FL45TZ.
Vancouver
1.Hülya Duran, Nihan Çeken, Tuğba Kula Atik, Esma Yeniiz. Contribution of laboratory data to diagnosis and treatment in patients with brucellosis: a 5-year cross-sectional analysis. J Health Sci Med / JHSM [Internet]. 2026 Jul. 1;9(4):933-7. Available from: https://izlik.org/JA87FL45TZ

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