The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit
Abstract
Aims: To evaluate the role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline.
Methods: This retrospective study included 320 pregnant female who delivered at the Perinatology Unit of Şanlıurfa Training and Research Hospital. Participants were divided into two groups according to postpartum hemoglobin decline; <2 g/dl (n=160) and ≥2 g/dl (n=160). Maternal demographic characteristics, obstetric data, first-trimester complete blood count parameters, and delivery and postpartum outcomes were analyzed. Variables associated with clinically significant postpartum hemoglobin decline were assessed using logistic regression analysis, and predictive performance was evaluated by receiver operating characteristic analysis.
Results: Female with postpartum hemoglobin decline ≥2 g/dl had lower first-trimester hemoglobin and hematocrit levels and higher red cell distribution width and Mentzer Index values. This group also had significantly higher rates of cesarean delivery, estimated blood loss, postpartum hemorrhage, additional uterotonic requirement, red blood cell transfusion, and longer hospital stay. In multivariable analysis, lower first-trimester hemoglobin, higher red cell distribution width, higher Mentzer Index, and cesarean delivery remained independent predictors. The combined model showed better discriminative performance than any single marker.
Conclusion: First-trimester hematological parameters, particularly hemoglobin, red cell distribution width, and Mentzer Index, are associated with clinically significant postpartum hemoglobin decline. These readily available markers may contribute to early obstetric risk stratification.
Keywords
Supporting Institution
The authors declare that this study received no financial support.
Ethical Statement
The study was approved by the Ethics Committee of Diyarbakır Gazi Yaşargil Training and Research Hospital (Approval No: 99, Date: 02.03.2026).
Thanks
None
References
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Details
Primary Language
English
Subjects
Obstetrics and Gynaecology
Journal Section
Research Article
Publication Date
July 20, 2026
Submission Date
April 6, 2026
Acceptance Date
June 25, 2026
Published in Issue
Year 2026 Volume: 9 Number: 4
APA
Taşdemir, D., & Haksever, M. (2026). The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit. Journal of Health Sciences and Medicine, 9(4), 1058-1065. https://doi.org/10.32322/jhsm.1924174
AMA
1.Taşdemir D, Haksever M. The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit. J Health Sci Med / JHSM. 2026;9(4):1058-1065. doi:10.32322/jhsm.1924174
Chicago
Taşdemir, Deniz, and Murat Haksever. 2026. “The Role of First-Trimester Hematological Parameters in Predicting Clinically Significant Postpartum Hemoglobin Decline: A Retrospective Study from a Perinatology Unit”. Journal of Health Sciences and Medicine 9 (4): 1058-65. https://doi.org/10.32322/jhsm.1924174.
EndNote
Taşdemir D, Haksever M (July 1, 2026) The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit. Journal of Health Sciences and Medicine 9 4 1058–1065.
IEEE
[1]D. Taşdemir and M. Haksever, “The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit”, J Health Sci Med / JHSM, vol. 9, no. 4, pp. 1058–1065, July 2026, doi: 10.32322/jhsm.1924174.
ISNAD
Taşdemir, Deniz - Haksever, Murat. “The Role of First-Trimester Hematological Parameters in Predicting Clinically Significant Postpartum Hemoglobin Decline: A Retrospective Study from a Perinatology Unit”. Journal of Health Sciences and Medicine 9/4 (July 1, 2026): 1058-1065. https://doi.org/10.32322/jhsm.1924174.
JAMA
1.Taşdemir D, Haksever M. The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit. J Health Sci Med / JHSM. 2026;9:1058–1065.
MLA
Taşdemir, Deniz, and Murat Haksever. “The Role of First-Trimester Hematological Parameters in Predicting Clinically Significant Postpartum Hemoglobin Decline: A Retrospective Study from a Perinatology Unit”. Journal of Health Sciences and Medicine, vol. 9, no. 4, July 2026, pp. 1058-65, doi:10.32322/jhsm.1924174.
Vancouver
1.Deniz Taşdemir, Murat Haksever. The role of first-trimester hematological parameters in predicting clinically significant postpartum hemoglobin decline: a retrospective study from a perinatology unit. J Health Sci Med / JHSM. 2026 Jul. 1;9(4):1058-65. doi:10.32322/jhsm.1924174
