Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers

Deniz Kamacı Şener; Şenay Fırat; Özden Kamışlı

doi:10.32322/jhsm.1939967

Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers

Abstract

Aims: Migraine is a common neurological disorder that has been associated with various metabolic and cardiovascular conditions. The Triglyceride-Glucose (TyG) Index and the Atherogenic Index of Plasma (AIP) are practical markers used to assess insulin resistance and cardiometabolic risk. This study aimed to evaluate TyG and AIP levels in patients with migraine and compare them with healthy controls. Methods: This retrospective cross-sectional study included adult patients diagnosed with migraine according to the International Classification of Headache Disorders, 3rd edition (ICHD-3). Demographic and clinical data, along with laboratory parameters, were recorded. TyG Index and AIP values were calculated and compared with those of age- and sex-matched healthy individuals. Results: TyG Index and AIP values were significantly higher in patients with migraine compared to controls. Glucose and TyG levels were highest in patients with chronic migraine. In the episodic migraine group, both indices were positively correlated with BMI, whereas TyG also showed a positive correlation with age. Conclusion: Elevated TyG and AIP values in patients with migraine may reflect underlying cardiometabolic alterations and vascular susceptibility. These surrogate indices may contribute to a better understanding of the relationship between migraine and cardiometabolic pathways.

Keywords

Supporting Institution

none

Ethical Statement

• Ethical approval was obtained from the Bursa City Hospital Ethics Committee (Date: 30.10.2024; Approval No: E-13012450-514.99-2592265431).

Thanks

none

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Details

Primary Language

English

Subjects

Neurology and Neuromuscular Diseases

Journal Section

Research Article

Authors

Deniz Kamacı Şener ^*
0000-0003-3433-6859
Türkiye

Şenay Fırat
0000-0002-0011-8661
Türkiye

Özden Kamışlı
0000-0003-1114-7860
Türkiye

Publication Date

July 20, 2026

Submission Date

April 29, 2026

Acceptance Date

June 28, 2026

Published in Issue

Year 2026 Volume: 9 Number: 4

DOI

https://doi.org/10.32322/jhsm.1939967

IZ

https://izlik.org/JA72LE63MH

Cite

RIS / Bibtex

APA

Kamacı Şener, D., Fırat, Ş., & Kamışlı, Ö. (2026). Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers. Journal of Health Sciences and Medicine, 9(4), 1097-1103. https://doi.org/10.32322/jhsm.1939967

AMA

1.Kamacı Şener D, Fırat Ş, Kamışlı Ö. Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers. J Health Sci Med / JHSM. 2026;9(4):1097-1103. doi:10.32322/jhsm.1939967

Chicago

Kamacı Şener, Deniz, Şenay Fırat, and Özden Kamışlı. 2026. “Triglyceride–Glucose Index and Atherogenic Index of Plasma in Migraine: A Cross-Sectional Study of Cardiometabolic Surrogate Markers”. Journal of Health Sciences and Medicine 9 (4): 1097-1103. https://doi.org/10.32322/jhsm.1939967.

EndNote

Kamacı Şener D, Fırat Ş, Kamışlı Ö (July 1, 2026) Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers. Journal of Health Sciences and Medicine 9 4 1097–1103.

IEEE

[1]D. Kamacı Şener, Ş. Fırat, and Ö. Kamışlı, “Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers”, J Health Sci Med / JHSM, vol. 9, no. 4, pp. 1097–1103, July 2026, doi: 10.32322/jhsm.1939967.

ISNAD

Kamacı Şener, Deniz - Fırat, Şenay - Kamışlı, Özden. “Triglyceride–Glucose Index and Atherogenic Index of Plasma in Migraine: A Cross-Sectional Study of Cardiometabolic Surrogate Markers”. Journal of Health Sciences and Medicine 9/4 (July 1, 2026): 1097-1103. https://doi.org/10.32322/jhsm.1939967.

JAMA

1.Kamacı Şener D, Fırat Ş, Kamışlı Ö. Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers. J Health Sci Med / JHSM. 2026;9:1097–1103.

MLA

Kamacı Şener, Deniz, et al. “Triglyceride–Glucose Index and Atherogenic Index of Plasma in Migraine: A Cross-Sectional Study of Cardiometabolic Surrogate Markers”. Journal of Health Sciences and Medicine, vol. 9, no. 4, July 2026, pp. 1097-03, doi:10.32322/jhsm.1939967.

Vancouver

1.Deniz Kamacı Şener, Şenay Fırat, Özden Kamışlı. Triglyceride–Glucose Index and Atherogenic Index of plasma in migraine: a cross-sectional study of cardiometabolic surrogate markers. J Health Sci Med / JHSM. 2026 Jul. 1;9(4):1097-103. doi:10.32322/jhsm.1939967