Investigation of gestational diabetic lipid levels

Abstract

Aim: Abnormal lipid profiles have been associated with gestational diabetes mellitus (GDM). We aimed to investigatethe lipid profile in gestational diabetes.

Methots:  This study was included 127 GDM and 30 healthy pregnant women to control group, similar BMI, gestational week and age group. Total cholesterol, high density lipoprotein (HDL-C) plasma concentrations were measured by cholesterol enzymatic tests. Low-density lipoprotein cholesterol (LDL-C) was calculated using Friedewald's formula.

Findings: Triglyceride, Total Cholesterol and LDL-C levels were found to be increased in pregnancy. However, it was not statistically significant. GDM compared with the control group in HDL-C were statistically significantly lower. When logistic regression was performed, HDL was lower than GDM control, regardless of age, BMD, gestational week. When Roc analysis was performed, it was seen that HDL <70 mg / dL GDM was predicted with 83% specificity and 64% sensitivity.

Results: Low HDL-C concentrations were significantly associated with an increased risk of GDM. Total cholesterol, LDL-C, TG values were not significantly elevated.

Keywords

• Gestasyonel diyabetes mellitus (gdm),Lipid düzeyleri,Total kolesterol,Hdl-k,Ldl-k,Trigliserit

Gestasyonel diyabette lipid düzeylerinin incelenmesi

Abstract

Amaç: Anormal lipid profilleri gestasyonel diabetes mellitus (GDM) ile ilişkilendirilmiştir. Biz gestasyonel diyabette lipid profilini incelemeyi amaçladık.

Metod: Çalışmamıza 127 GDM’li ve kontrol grubu olarak benzer BMİ, gebelik haftası ve yaş grubundan 30 sağlıklı gebe dahil edildi. Kan örnekleri12 saat açlıktan sonra alındı.  Trigliserid, Total Kolesterol, yüksek yoğunluklu lipoprotein(HDL-K)plazma konsantrasyonları kolesterol enzimatik testlerle ölçüldü. Düşük yoğunluklu lipoprotein kolesterol(LDL-K) Friedewald'ın formülü ile hesaplandı.

Bulgular: Trigliserid, Total Kolesterol ve LDL-K düzeyleri gebelikte artmış olarak bulundu. Ancak istatistiksel olarak anlamlı değildi. Hdl-k GDM grubunda kontrol ile karşılaştırılınca istatistiksel olarak anlamlı bir şekilde düşük bulundu. Logistik regresyon yapıldığında HDL’nin GDM’de kontrole göre düşük olması yaş, BMİ, gebelik haftasından bağımsız olarak bulundu. Roc analiz yapıldığında HDL < 70 mg/dl  GDM’yi %83 spesifite,  %64 sensivite ile predikte ettiği görüldü.

Sonuç: Düşük HDL-C konsantrasyonları, GDM riskinde artış ile anlamlı şekilde ilişkiliydi. Total kolesterol, LDL-C, TG değerlerinde anlamlı yükselmeler görülmedi.

Keywords

• Gestasyonel diyabetes mellitus (gdm),Lipid düzeyleri,Total kolesterol,Hdl-k,Ldl-k,Trigliserit

References

1. References 1. American Diabetes Association. Gestational diabetes mellitus. Diabetes Care. 2004; 27:S88-90. 2. Wang Q, Würtz P, Auro K, Mäkinen VP, Kangas AJ, Soininen P, Tiainen M, Tynkkynen T, Jokelainen J, Santalahti K, Salmi M, Blankenberg S, Zeller T, Viikari J, Kähönen M, Lehtimäki T, Salomaa V, Perola M, Jalkanen S, Järvelin MR, Raitakari OT, Kettunen J, Lawlor DA, Ala-Korpela M. Metabolic profiling of pregnancy: cross-sectional and longitudinal evidence. BMC Med. 2016 Dec 13;14(1):205. 3. Brizzi P1, Tonolo G, Esposito F, Puddu L, Dessole S, Maioli M, Milia S.Lipoprotein metabolism during normal pregnancy.Am J Obstet Gynecol. 1999 Aug;181(2):430-4 4. Goode GK, Miller JP, Heagerty AM. Hyperlipidemia,hypertension, and coronary heart desease. Lancet 1995;345: 362-4 5. Stewart DJ, Monge JC. Hyperlipidemia and endothelial dysfuntion. Curr Opin Lipidol 1993; 4: 319-24. 6. Meyers-Seifer CH, Vohr BR. Lipid levels in former gestational diabetic mothers. Diabetes Care 1996;19(12):1351-6. 41. 7. Dornhorst A, Bailey PC, Anyaoku V, Elkeles RS, Johnston DG, Beard RW. Abnormalities of glucose tolerance following gestational diabetes. Q J Med 1990;77(284):1219-28. 8. Cooney MT, Dudina A, Whincup P, Capewell S, Menotti A, Jousilahti P, Njølstad I, Oganov R, Thomsen T, Tverdal A, Wedel H, Wilhelmsen L, GrahamI.ReevaluatingtheRoseapproach: comparativebenefits of thepopulationandhighriskpreventivestrategies. Eur J CardiovascPrevRehabil 2009;16:541–549 9. Lippi G, Albiero A, Montagnana M, Salvagno GL, Scevarolli S, Franchi M, Guidi GC. Lipid and lipoprotein profile in physiological pregnancy. Clin Lab. 2007;53(3-4):173-7 10.Ryckman KK, Spracklen CN, Smith CJ, Robinson JG, Saftlas AF. Maternal lipid levels during pregnancyand gestational diabetes: a systematic review and meta-analysis. BJOG. 2015; 122:643-51. 11. Klingel R, Gohlen B, Schwarting A, Himmelsbach F, Straube R. Differential indication of lipoprotein apheresis during pregnancy. Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy. 2003;7(3):359-64 12. Knopp RH, Bergelin RO, Whal PW, et al: Population-lased lipoprotein lipid reference values for pregnant women compared to nonpregnant women classified by sex hormone usage. Am J Obstet Gynecol 143:626-637, 1982. 13. Jimenez SM, Pocovi M, Ramon-Caja J, et al: Longitidunal study of plasma lipids and lipoprotein cholesterol in normal pregnancy and puerperium. Gynecol Obstet Invest 25:158-164, 1988 14. Chirico S, Smith C, Merchant C, et al: Lipid peroxidation in hiperlipidemic patients; a study of plasma using an HdLC-based thiobarbituric acid test. Free Radic Res Commun 19:51-7, 199