Vitamin D yetersizliği ve eksikliğine güncel yaklaşım

Year 2019, , 58 - 61, 01.04.2019

Murat Doğan , Ayşe Gülşen Doğan

https://doi.org/10.32322/jhsm.496326

Cited By: 1

Abstract

Vitamin D
adipoz dokuda eriyen sekosteroid yapıda bir hormon olup en önemli etkisi kemik
metabolizması ve serum kalsiyum dengesi üzerindedir. Vitamin D eksikliği ve
yetersizliği kanser, enfeksiyöz hastalık, metabolik sendrom, hipertansiyon,
miyokard enfarktüsü ve kardiyovasküler hastalık sonucu ölüm riskinin artması,
multipl skleroz, romatoid artrit, tip I diyabet dahil olmak üzere bir çok
otoimmün hastalıkların insidansı ve şiddeti ile ilişkilendirilmiştir. Vitamin D’nin optimal düzeyi hakkında bir fikir birliğine
varılmamış olsa da çoğu araştırmacı tarafından 25(OH)D düzeyinin; 30 ng/mL’nin
üzerindeki değer yeterli, 20 ile 30 ng/mL arasındaki değer yetersizlik, 20
ng/mL’nin altındaki değer eksiklik olarak kabul edilir. Ülkemizde
vitamin D eksikliğinin sık görülmesi ve vitamin D eksikliğinin kanser, sistemik
hastalıklar ve kemik sağlığı üzerine olumsuz etkilerinden dolayı bu derlemede, erişkinlerde D vitamini
fizyolojisinin anlaşılması, vitamin D eksikliğinin tanımlanması ve tedavi
sürecinde güncel yaklaşım sunmayı amaçladık.

Keywords

Vitamin D eksikliği, yetersizliği, tanı, güncel tedavi

Current approach to vitamin D insufficiency and deficiency

Abstract

Vitamin D is a secosteroid hormone in adipose tissue
which has a significant impact on the bone metabolism and serum calsium
balance. Vitamin D deficiency and insufficiency associated with the incidence
and severity of many autoimmune diseases including common cancers, infectious
diseases, metabolic syndrome, hypertension, myocardial infarctions and increase
of the risc of cardiovasculer illnesses, multipl sclerosis, rheumatoid
arthritis and type 1 diabetes. Although there is no consensus on optimal level
of vitamin D the most researches have accepted the level of 25(OH)D in the
following order: the value above 30 ng/mL indicates competency, between 20-30
ng/mL indicates insufficiency, below 20 ng/mL indicates deficiency. In our
country vitamin D deficiency is a common problem and it has a negative effects on
cancer, systematic diseases, bone health therefore in our revieve we aimed to
present the physiology of vitamin D in adults, define vitamin D deficiency and present
the current approach in the treatment process.

Keywords

Vitamin D deficiency, insufficiency, diagnosis, current treatment

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