Is IGF-1 level actually lowered in the early stage following an acute myocardial infarction and is IGF-1 associated with the left ventricle dysfunction or cardiac events?

Yıl 2020, , 1 - 6, 15.01.2020

Yücel Yılmaz , Fatih Tanrıverdi , Mustafa Duran , Mustafa Altay Namık Kemal Eryol

https://doi.org/10.32322/jhsm.504184

Öz

Background: Insulin-like growth factor
(IGF) is the primary mediator of growth hormone. IGF-1 may have an important
role in protecting the myocardial functions following an acute myocardial
infarction (AMI). Literature reveals only a limited number of studies
investigating the relationship between the serum IGF-1/IGF binding protein-3 (IGFBP-3)
levels and the left ventricular functions post AMI.  We aimed to determine
IGF-1 and IGFBP-3 levels and evaluate their effect on cardiac functions post
AMI.

Material and Method: Sixty five patients who were included
in the study and the control group had 26 patients. Blood samples of the
patients were obtained on the second day of their admission. The patients
underwent echocardiographic examination on the 7^th day of their
hospitalization.

Results: The serum IGF-1 and IGFBP-3 levels of the patient group were
higher than those of the control group; however only IGF-1 levels were
statistically significant (243,2±87,9 ng/mL versus 177,2±81,8 ng/mL p=0,001).
The increase in the wall thickness and LV chamber size did not correlate with
the decrease in LVEF and IGF-1/IGFBP-3 levels. The patients who had minor
cardiac events had lower IGF-1 levels but this was not statistically
significant (210.5±88.5 versus 253.1±86.1 p>0.05).

Conclusion: IGF-1 and IGFBP-3 levels elevated
following an the early AMI, but these markers were not correlated with the
echocardiographical measurements in early post MI period.

Anahtar Kelimeler

Insulin-like growth factor, Insulin-like growth factor binding proteins, acute myocardial infarction

Serum IGF-1 düzeyleri akut miyokard infarktüsü sonrası gerçekten azalır mı ve sol ventrikül disfonksiyonu ile ilişkili midir?

Öz

Giriş; İnsülin benzeri büyüme faktörü (İGF), büyüme hormonunun primer mediatördür. İGF-1 akut miyokard infarktüsü (AMİ) sonrası miyokard fonksiyonlarının korunmasında önemli olabilir. Literatürde AMI sonrası İGF-1/İGF binding protein-3 (IGFBP-3) ​​düzeyleri ile sol ventrikül fonksiyonları arasındaki ilişkiyi araştıran sınırlı sayıda çalışma vardır. Bizim amacımız, AMİ sonrası serum İGF-1 ve İGFBP-3 düzeylerini belirlemek ve kardiyak fonksiyonlar üzerindeki etkisini değerlendirmektir.

Çalışma planı; Çalışamaya koroner yoğun bakım ünitesine yatırılan ve kabul edilme kriterlerine sahip olan 65 hasta alındı. Kontrol grubu daha önce koroner arter hastalığı olmayan ve dışlanma kriterlerine sahip olmayan 26 kişiden oluşturuldu. Hastaların kan örnekleri aç olarak yatışının ikinci gününde alındı. Serum İGF-1 ve İGFBP-3 düzeyleri ölçüldü. Hastaların ekokardiyografik değerlendirmesi ortalama yatışının 7. gününde yapıldı.

Bulgular; Hasta grubunun serum İGF-1 ve İGFBP-3 düzeyleri kontrol grubuna göre daha yüksek tespit edildi. Ancak sadece IGF-1 düzeyleri (243,2 ± 87,9 ng / ml ve 177,2 ± 81,8 ng / ml p = 0.001) istatistiksel olarak anlamlı idi. Sol ventrikül (SV) duvar kalınlığı ve boşluk boyutlarındaki artış veya SV ejeksiyon fraksiyonlarındaki azalma ile İGF-1/İGFBP-3 düzeyleri arasında ilişki saptanmadı. Hasta grubunda minör kardiyak olaylar ile düşük İGF-1 düzeyleri arasında istatiksel olarak anlamlı olmayan bir ilişki tespit edildi. (253,1 ± 86,1 ve 210,5 ± 88,5 p> 0.05).

Sonuç; Daha önceki benzer çalışma sonuçlarından farklı olarak AMİ sonrası serum İGF-1 düzeylerinde yükselme tespit ettik. Ancak İGF-1 düzeyleri ile hastane içi kardiyak olaylar ve ekokardiyografik parametreler arasında ilişki bulamadık. AMİ ile İGF / İGFBP düzeyleri arasındaki bağlantılar karmaşık gibi görünmektedir ve bu ilişkiyi açıklamak için daha ileri çalışmalar gereklidir.

Anahtar Kelimeler

: İnsülin benzeri büyüme faktörü, insülin benzeri büyüme faktörü bağlayıcı proteinler, akut miyokard infarktüsü

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