Determinants of intensive care prognosis in patients with “platelet indices” in chronic obstructive pulmonary disease and lung cancer

Abstract

Aim: Platelet activation and consumption indicate worse prognosis in critical ill patients. Researchers found that the lungs play an important role in the production of mature platelets. Chronic obstructive pulmonary disease(COPD) is a respiratory disease affects the lungs and also has systemic effects due to inflammation. This study was conducted to examine prognosis and mortality with Platelet indices in COPD and lung cancer patients in intensive care. Methods: We extracted clinical datas including patient demographics, Charlson Comorbidite Index, Acute Physiology and Chronic Health Evaluation II, Sequential Organ Failure Assessment scores, length of stay in ICU, length of stay in hospital, duration of mechanical ventilation, inotrope use, Plt count, MPV, PDW, and PCT values and 30-day mortality retrospectively. Results: This study was conducted with the 344 COPD and 84 lung cancer patients’ data analysis admitted to ICU .In this study we found that Plt count, PDW, and MPV are also predict COPD while Plt count and MPV predict lung cancer.The study shown that, CCI, APACHE II, SOFA score, intrope use, MV duration and mortality were higher in lung cancer patients compared to COPD patients. Conclusion: Plt indices can be a determinant in patients with COPD and lung cancer but they might not make a clear distinction for prognosis.

Keywords

• Platelet Indices
• Chronic obstructive pulmonary disease
• Lung Cancer
• Platelet count
• MPV
• intensive care

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