Evaluation of serum perlecan levels in pregnancy with mild and severe preeclampsia

Abstract

Aim: To determine the levels of perlecan, which contributes to autophagy inhibition and angiogenesis, in severe and mild preeclamptic women. Material and Method: A total of 89 patients including severe preeclampsia, group 1 (n: 30), mild preeeclampsia, group 2 (n: 30) and control group, group 3 (n: 29) were included in the study. Results: All three groups were evaluated in terms of perlecan levels. Perlecan level in group 1 was determined at higher levels than other groups, and this level difference was statistically significant compared to the other two groups (p <0.0001). Group 2 was found to be significantly higher in favor of group 2 when compared with the control group (p <0.0001). Considering the distribution and average values of the Perlecan level among the groups, 2.43 ng / ml in group 1, 1.22 ng / ml in group 2 and 0.89 ng / ml in the control group were detected. In the correlation of perlecan level with hematological parameters, we found that systolic blood pressure, diastolic blood pressure, AST, ALT, creatinine, proteinuria, and LDH levels were positively correlated with perlecan level in the severe preeclampsia group. Conclusion: In our study, we found that serum perlecan levels were higher in preeclamptic pregnant women and this increased more especially in those with severe preeclampsia clinic.

Keywords

• Perlecan
• preeclampsia
• autophagy
• angiogenesis
• pathophysiology

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