Impact of Ramadan fasting on eGFR in patients with late stage chronic kidney disease

Yıl 2023, Cilt: 6 Sayı: 5, 1016 - 1021, 28.09.2023

Mahmud İslam

https://doi.org/10.32322/jhsm.1330331

Cited By: 1

Öz

Aims: Ramadan fasting is a significant religious practice observed annually by approximately 1.9 billion adult Muslims worldwide. However, its potential impact on kidney health in individuals with chronic kidney disease (CKD) remains a subject of concern. This study aimed to investigate the effects of Ramadan fasting on renal function in patients with stage 3-5 CKD and to identify any associated risk factors.
Methods: A single-center, self-controlled longitudinal observational study was conducted on 192 stable patients with stage 3-5 CKD who observed Ramadan fasting. The fasting period was about 14-15 hours per day for one month Various clinical parameters, including eGFR, blood urea nitrogen (BUN), sodium (Na+), potassium (K+), calcium (Ca++), phosphorus, parathyroid hormone (PTH), albumin, uric acid, fasting glucose, total cholesterol, triglyceride, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and hemoglobin (Hgb), were measured before and after Ramadan fasting. P<0.05 was assumed significant.
Results: The study results demonstrated no significant deterioration in eGFR during Ramadan fasting (pre-Ramadan: 43.54±11.04 vs post-Ramadan: 44.28±11.51, p=0.063). Additionally, traditional risk factors for CKD progression, such as diabetes mellitus (DM), hypertension (HT), cardiovascular disease CVD, and age, did not show a significant association with eGFR changes during fasting (p>0.05). Furthermore, the use of angiotensin-converting enzyme inhibitors/angiotensin receptor blockers (ACEi/ARB) did not impact eGFR (0.084). Notably, Ramadan fasting led to improvements in metabolic parameters, such as fasting glucose and lipid profile, except for triglyceride levels (p<0.001).
Conclusion: The study results indicate that Ramadan fasting does not appear to have adverse effects on kidney function in individuals with CKD, although certain metabolic changes were observed.

Anahtar Kelimeler

Ramadan fasting, chronic kidney disease, glomerular filtration rate, metabolic parameters, kidney function

Teşekkür

The author would like to thank Prof. Dr. Hamad Dheir for ideas and suggestions for improving the manuscript. Great thanks to my nurses: Betul Turkoglu and Sonay Boz, for their assistance in organizing and supervising the study population. Finally, warm thanks to Medical secretery Ayşe Karagülmez for her organiztion efforts in our nephrogy outpatient clinic .

Kaynakça

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