-

Abstract

Early detection of disease plays a crucial role in successful therapy. In most cases, the earlier the disease is diagnosed, the more likely it is to be successfully cured or well controlled. Salivary diagnostics offer an easy, inexpensive, safe and non-invasive approach for disease detection. This article presents an overview of salivary biomarkers for oral cancers, sistemic infections and peridontal diseases.

Keywords

• Biomarkers, saliva, early detection of disease

TÜKÜRÜK BİYOMARKERLARIN ERKEN TANIDAKİ ROLÜ-The Role of Salivary Biomarkers in Early Diagnostics

Abstract

ÖZ

Erken tanı, başarılı bir tedavide önemli rol oynar. Birçok vakada, hastalığın erken tanısı ile başarılı bir tedavi ya da kontrol gerçekleştirilebilmektedir. Tükürük tanı yöntemleri, hastalık tanısında kolay, ucuz, güvenilir ve invazif olmayan uygulamaları içermektedir. Bu makale, ağız kanserleri, sistemik enfeksiyonlar, periodontal hastalık tanısında kullanılan tükürük biyomarkerlarına ilişkin genel bilgi içermektedir.

Anahtar kelimeler: Biyomarker, tükürük, erken tanı

ABSTRACT

Early detection of disease plays a crucial role in successful therapy. In most cases, the earlier the disease is diagnosed, the more likely it is to be successfully cured or well controlled. Salivary diagnostics offer an easy, inexpensive, safe and non-invasive approach for disease detection. This article presents an overview of salivary biomarkers for oral cancers, sistemic infections and peridontal diseases.

Keywords: Biomarkers, saliva, early detection of disease

Keywords

• Biyomarker, tükürük, erken tanı

References

1. Marieb EN, Hoehn K. Human anatomy and physiology. 8th ed., San Francisco: Benjamin Cummings, 2009. Miller CS, Foley JD, Bailey AL, Campell CL, Humphries RL, Christodoulides N, Floriano PN, Simmons G, Bhagwandin B, Jacobson JW, Redding SW, Ebersole JL, McDevitt JT. Current developments in salivary diagnostics. Biomark Med, 2010; 4(1): 171 Lee YH, Wong DT. Saliva: an emerging biofluid for early detection of diseases. Am J Dent, 2009; 22(4): 241-48. Nagler R, Bahar G, Shpitzer T, Feinmesser R. Concomitant analysis of salivary tumor markers: a new diagnostic tool for oral cancer. Clin Cancer Res, 2006; 12(13): 3979–84. Sidransky D. Nucleic acid-based methods for the detection of cancer. Sciences, 1997; 278(5340): 1054–59. Tavassoli M, Brunel N, Maher R, Johnson NW, Soussi, T. p53 antibodies in the saliva of patients with squamous cell carcinoma of the oral cavity. Int J Cancer, 1998; 78(3): 390–91. Wagner P, Verma M, Srivastava S. Challenges for biomarkers in cancer detection. Ann NY Acad Sci, 2004; 1022: 9-16. Wong LJ, Lueth M, Li XN, Lau CC, Vogel H. Detection of mitochondrial DNA mutations in the tumor and cerebrospinal fluid of medulloblastoma patients. Cancer
2. Res, 2003; 63(14): 3866–71. Kocík M, Vymetalová Y, Málek I. Cellfree human DNA in body fluids-potential for clinical applications. Cas Lek Cesk, 2007; 146(2): 96–101. Schrohl AS, Würtz S, Kohn E, Banks
3. RE, Nielsen HJ, Sweep FC, Brünner N. Banking of biological fluids for studies of disease-associated protein biomarkers. Mol Cell Proteomics, 2008; 7(10): 2061–66. Gillison ML, Koch WM, Capone RB, Spafford M, Westra WH, Wu L, Zahurak
4. ML, Daniel RW, Viglione M, Symer DE, Shah KV, Sidransky D. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst, 2000; 92(9): 709–20. Herrero R, Castellsagué X, Pawlita M, Lissowska J, Kee F, Balaram P, Rajkumar
5. T, Sridhar H, Rose B, Pintos J, Fernandez L, Idris A, et al. Human papillomavirus and oral cancer: the International Agency for Research on Cancer multicenter study. J Natl Cancer Inst, 2003; 95(23): 1772–83. Farnaud SJ, Kosti O, Getting SJ, Renshaw D. Saliva: physiology and diagnostics potential in health and disease. Scientific
6. World Journal, 2010; 10: 434-56. Smith EM, Ritchie JM, Summersgill
7. KF, Klussmann JP, Lee JH, Wang D, Haugen TH, Turek LP. Age, sexual behavior and human papillomavirus infection in oral cavity and oropharyngeal cancers. Int J Cancer, 2004; 108(5): 766–72. Eguchi J, Ishihara K, Watanabe A, Fukumoto Y, Okuda K. PCR method is essential for detecting mycobacterium tuberculosis in oral cavity samples. Oral Microbiol Immunol, 2003; 18(3): 156–59.
8. Ahmed KS, Khan AA, Ahmed I, Tiwari SK, Habeeb MA, Ali SM, Ahi JD, Abid Z, Alvi A, Hussain MA, Ahmed N, Habibullah CM. Prevalence study to elucidate the transmission pathways of helicobacter pylori at oral and gastroduodenal sites of a South Indian population. Singapore Med J, 2006; 47(4): 291–96.

9. Park NJ, Li Y, Yu T, Brinkman BM, Wong DT. Characterization of RNA in saliva. Clin Chem, 2006; 52(6): 988–94.
10. Giannobile WV, McDevitt JT, Niedbala RS, Malamud D. Translational and clinical applications of salivary diagnostics. Adv Dent Res, 2011; 23(4): 375-80.
11. Griffiths GS. Formation, collection and significance of gingival crevice fluid. Periodontol 2000, 2003; 31: 32–42.
12. Hu S, Xie Y, Ramachandran P, Ogorzalek Loo RR, Li Y, Loo JA, Wong DT. Large-scale identification of proteins in human salivary proteome by liquid chromatography/ mass spectrometry and two-dimensional gel electrophoresis-mass spectrometry. Proteomics, 2005; 5(6): 1714–28.
13. Li Y, Zhou X, St John MA, Wong DT. RNA profiling of cell-free saliva using microarray technology. J Dent Res, 2004; 83(3): 199–203.
14. Hu S, Wang J, Meijer J, Leong S, Xie YM, Yu T, Zhou H, Henry S, Vissink A, Pijpe J, Kallenberg C, Elashoff D, Loo JA, Wong DT. Salivary proteomic and genomic biomarkers for primary Sjögren’s syndrome. Arthritis Rheum, 2007; 56(11): 3588-600. Li Y, St John MA, Zhou X, Kim Y, Sinha U, Jordan RC, Eisele D, Abemayor E, Elashoff D, Park NH, Wong DT. Salivary transcriptome diagnostics for oral cancer detection. Clin Cancer Res, 2004; 10(24): 8442–50. Segal A, Wong DT. Salivary diagnostics: enhancing disease detection and making medicine better. Eur J Dent Educ, 2008; 12
15. Suppl 1: 22-29. Yazışma adresi : Melis ARAZ İstanbul Üniversitesi Diş Hekimliği Fakültesi Pedodonti A.D. 34093 Çapa-Fatih/İstanbul Tel: [phone]/ 30400 e-posta: [e-mail]