SİGARANIN MİNE MATRİKS PROTEİNLERİ VE BİYOAKTİF CAM ESASLI VEYA SIĞIR KAYNAKLI KEMİK GREFT MATERYALİ KOMBİNASYONLARI ÜZERİNE ETKİLERİ

Year 2011, Volume: 45 Issue: 3, 1 - 11, 26.08.2013

Şebnem Dirikan İpçi Gökser Çakar Gürlüman Berber Noyun Selçuk Yılmaz

Abstract

Bu çalışmada, sigaranın, mine matriks proteinleri (MMP) ve biyoaktif cam esaslı (BC) veya sığır kaynaklı kemik greft
(SKKG) materyali ile kombine kullanımı üzerindeki etkisinin değerlendirilmesi amaçlandı. Çalışmaya 10 sigara içen 10
sigara içmeyen 20 generalize agresif periodontitis hastası dahil edildi. Her hastada MMP+BC ve MMP+SKKG
kombinasyonları sondalama derinliği (SD) > 5 mm ve kemik içi defekt derinliği > 3 mm olan kemik içi defektlere uygulandı.
Klinik ve radyografik değerlendirmeler operasyondan önce ve operasyon sonrası 8. ayda yapıldı. Defektin en derin
noktasında, sigara içen bireylerde, MMP+BC ve MMP+SKKG gruplarında sırasıyla, 3.16±0.96 mm ve 3.09±1.18 mm SD
azalması, 1.86 ±0.72 mm ve 1.93±0.64 mm ataşman kazancı, 0.92±0.31 mm ve 1.24±0.33 mm klinik kemik kazancı,
0.59±0.80 mm ve 0.58±0.31 mm radyografik kemik kazancı, sigara içmeyen bireylerde, MMP+BC ve MMP+SKKG
gruplarında sırasıyla, 3.43±1.30 mm ve 3.55±1.07 mm SD azalması, 2.0±0.69 mm ve 2.17±0.61 mm ataşman kazancı,
1.20±0.25 mm ve 1.29±0.31 mm klinik kemik kazancı, 0.60± 0.75 mm ve 0.69±0.37 mm radyografik kemik kazancı elde
edildi. Her iki tedavi grubunda da sigara içen ve içmeyen bireyler arasında incelenen parametreler açısından istatistiksel
olarak anlamlı bir fark bulunmadı (p>0.05). Bu çalışmanın sınırları dahilinde sigaranın her iki rejeneratif materyal
kombinasyonları üzerinde anlamlı bir etkisinin olmadığı sonucuna varılabilir.

Keywords

Mine matriks proteinleri, biyoaktif cam, sığır kaynaklı kemik grefti, generalize agresif periodontitis, sigara

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