İMPLANTLARIN ERKEN DÖNEM BAŞARISINA PROFLAKTİK ANTİBİYOTİK KULLANILMASININ ETKİSİ

Year 2013, Volume: 47 Issue: 1, 38 - 46, 14.05.2013

Nilüfer Bölükbaşı Sinem Yeniyol Sinem Yeniyol Tayfun Özdemir Tayfun Özdemir

Abstract

Amaç: Bu retrospektif çalışmanın amacı pre-operatif doz ile birlikte post-operatif 5 gün veya sadece
post-operatif 5 gün boyunca antibiyotik profilaksisi yapılması ile hiç antibiyotik kullanılmamasının
etkinliğini karşılaştırmaktır.
Gereç ve Yöntem: Çalışmaya 150 hasta 403 implant dâhil edilmiştir. Komplikasyonlar (enfeksiyon,
implant kaybı, yara kenarında açılma, kanama) ve subjektif hasta şikayetleri (ağrı, ödem, hematom,
gastrointestinal şikâyet) değerlendirilmiştir.
Bulgular: Hiçbir hasta gastrointestinal şikâyet veya hemoraji bildirmemiştir. Hastaların çoğunda
ödem görülmüştür. Çalışma grupları arasında diğer komplikasyonlar ve şikâyetler arası istatistiksel
olarak anlamlı fark bulunmamıştır.
Sonuç: Bu çalışmanın sonuçları, 5 gün süre ile uygulanan antibiyotik profilaksisinin hiç antibiyotik
kullanılmamasına göre üstünlük kazandırmadığını göstermektedir. Kesin sonuçlara varmak için hasta
sayısının yüksek olduğu uzun dönemli randomize takip çalışmaları gerekmektedir.

Keywords

İmplant, antibiyotik, profilaksi, implant başarı oranı

References

• Maestre Vera JR, Gómez-Lus Centelles ML. Antimicrobial prophylaxis in oral surgery and dental procedures. Med Oral Patol Oral Cir Bucal, 2007; 12(1): E44-52. Peterson LJ. Antibiotic prophylaxis against wound infections in oral and maxillofacial surgery. J Oral Maxillofac Surg, 1990; 48(6): 617-20. Olson M, O’Connor M, Schwartz ML.
• Surgical wound infection: a 5-year prospective study of 10193 wounds at the Minneapolis VA Medical Center. Ann Surg, 1984; 199(3): 253-59.
• Boyle N, Gallagher C, Sleeman D. Antibiotic prophylaxis for bacterial endocarditis--a study of knowledge and application of guidelines among dentists and cardiologists. J Ir Dent Assoc, 2006; 51(5): 232-37.
• Gould FK, Elliott TS, Foweraker J, Fulford M, Perry JD, Roberts GJ, Sandoe JA, Watkin RW. Guidelines for the prevention of endocarditis: report of the Working Party of the British Society for Antimicrobial Chemotherapy. J Antimicrob Chemother, 2006; 57(6): 1035-42.
• Wilson W, Taubert KA, Gewitz M, Lockhart PB, Baddour LM, Levison M, Bolger A, Cabell CH, Takahashi M, Baltimore RS, Newburger JW, Strom BL, Tani LY, Gerber M, Bonow RO, Pallasch T, Shulman ST, Rowley AH, Burns JC, Ferrieri P, Gardner T, Goff D, Durack DT; American Heart Association. Prevention of infective endocarditis. Guidelines from the American Heart Association: a guideline from the American Heart Association Rheumatic Fever, Endocarditis and Kawasaki Disease Committee, Council on Clinical Cardiology, Council on Cardiovascular Surgery and Anesthesia, and the Quality of Qare Outcomes Research Interdisciplinary Working Group. J Am Dent Assoc. 2008; 139 suppl: 3S-24S. Erratum in: J Am Dent Assoc, 2008; 139(3): 253.
• Page CP, Bohnen JMA. Antimicrobial prophylaxis for surgical wounds: Guidelines for clinical care. Arch Surg, 1993; 128(1): 79Dent CD, Olson JW, Farish SE, Bellome F, Casino AJ, Morris HF, Ochi S. The influence of preoperative antibiotics on success of endosseous implants up to and including stage II surgery: a study of 2,641 implants. J Oral Maxillofac Surg, 1997; 55(12 Suppl 5): 19-24.
• Göran W, Gynther, Per Ake Kandell, Moberg LE, Heimdahl A. Dental implant installation without antibiotic prophylaxis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998; 85(5): 509-11. Larsen P, McGlumphy E. Antibiotic prophylaxis for placement of dental implants.
• J Oral Maxillofac Surg, 1993; 51: 194. Laskin D, Dent C, Morris H. The Influence of preoperative antibiotics on success of endosseous implants at 36 months. Ann
• Periodontol, 2000; 5(1): 166-74. Mazzocchi A, Passi L, Moretti R. Retrospective analysis of 736 implants inserted without antibiotic therapy. J Oral Maxillofac
• Surg, 2007; 65(11): 2321-23. Peterson LJ. Long term antibiotic prophylaxis is not necessary for placement of dental implants. J Oral Maxillofac Surg, 1996; 54 (Suppl3): 76. Esposito M, Cannizzaro G, Bozzoli
• P, Checchi L, Ferri V, Landriani S, Leone M,Todisco M, Torchio C, Testori T, Galli F, Felice P. Effectiveness of prophylactic antibiotics at placement of dental implants: a pragmatic multicentre placebo-controlled randomised clinical trial. Eur J Oral Implantol, 2010; 3(2): 135-43. Binahmed A, Stoykewych A, Peterson
• L. Single preoperative dose versus long-term prophylactic antibiotic regimens in dental implant surgery. Int J Oral Maxillofac Implants, 2005; 20(1): 115-17. Karaky AE, Sawair FA, Al-Karadsheh OA, Eimar HA, Algarugly SA, Baqain
• ZH. Antibiotic prophylaxis and early dental implant failure: a quasi-random controlled clinical trial. Eur J Oral Implantol, 2011; 4(1): 31-38. Gynther GW, Köndell PA, Moberg
• LE, Heimdahl A. Dental implant installation without antibiotic prophylaxis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998; 85(5): 509-11.
• Mombelli A. Microbiology of the dental implant. Adv Dent Res, 1993; 7(2): 202-0
• Bölükbaşı N, Özdemir T, Öksüz L, Gürler N. Bacteremia following dental implant surgery: preliminary results. Med Oral Patol Oral Cir Bucal, 2012; 17(1): e69-75.
• Maestre JR, Giménez MJ, Bascones A et al. Odontopathogen susceptibility to amoxicillin/clavulanic acid and other common antibiotics used in odontology. 7th European Congress of Chemotherapy and Infection. October 19-22, Florence, Italy. 2005, p.209.
• Brescó-Salinas M, Costa-Riu N, Berini-Aytés L, Gay-Escoda C. Antibiotic susceptibility of the bacteria causing odontogenic infections. Med Oral Patol Oral Cir Buccal, 2006; 11(1): E70-75.
• Paterson JA, Cardo VA, Stratigos GT. An examination of antibiotic prophylaxis in oral and maxillofacial surgery. J Oral Surg, 1970; 28: 753-59.
• Lang NP, Wet, AC. Histologic probe penetration in healthy and inflamed periimplant tissues. In: Brånemark, P.-I., Zarb, G.A. & Albrektsson, T. eds. Tissue-Integrated prostheses: osseointegrationin clinical dentistry. Chicago: Quintessence, 1985; p.211-32.
• Quirynen M, De Soete M, van Steenberghe D. Infectious risks for oral implants: a review of the literature. Clin Oral Impl Res, 2002; 13(1): 1-19.
• Arısan V, Bölükbaşı N, Oksüz L. Computer-assisted flapless implant placement reduces the incidence of surgery-related bacteremia. Clin Oral Investig, 2012 Dec 6. Piñeiro A, Tomás I, Blanco J, Alvarez M, Seoane J, Diz P. Bacteraemia following dental implants’ placement. Clin Oral Implants Res, 2010; 21(9): 913-18. van Winkelhoff AJ. Antibiotics in the treatment of peri-implantitis. Eur J Oral Implantol, 2012; 5 Suppl: S43-50. Alanis A, Weinstein AJ. Adverse reactions associated with the use of oral penicillins and cephalosporins. Med Clin North Am, 1983; 67(1): 113-29. Yazışma Adresi: Nilüfer Bölükbaşı
• İstanbul Üniversitesi Diş Hekimliği Fakültesi Oral İmplantoloji A.D. 34093 Çapa-Fatih/İSTANBUL Tel: [phone] e-posta: [e-mail]