Abstract
Acromegaly is a rare disease characterized by bony and soft tissue overgrowth with an incidense of 3 cases per million population per year. These changes occur secondary to chronic hypersecretion of growth hormones by the anterior pituitary gland adenoma.In diagnosed acromegaly patients, radiotherapy after transsephonaidal or transfrontal surgery and systemical diseases such as diabetes, hypertension, cardiopulmonary diseases, sleep apnea, colon cancers and drugs should be considered. Acromegaly develops insidiously, the time between onset and diagnose of the disease may take 6-10 years. In the meantime, when symptoms such as enlargement in extremities, unexplained headache, visual disturbances, night sweat, prognathi inferior, diastemas, thickened lips, enlargened nose and macroglossia, condylar hyperplasia and unfitting prosthesis in edantolous patients raise doubts to acromegaly, evaluation of Insuline Like Growth Factor I and Growth Hormone levels in Oral Glucose Tolerance Test confirmation through magnetic resonance imaging is critical for early diagnose. In acromegaly cases mortality rate according to cardiovascular and respiratory diseases and malignancy is doubled.
Keywords
References
- Kashyap RR, Babu GS, Shetty SR. Dental patient with acromegaly: a case report. J Oral Sci, 2011; 53(1): 133-36. Thoma KH. Oral pathology: a histological rontgenological and clinical study of diseases of the teeth, jaws and mouth. 4th ed., St. Louis: Mosby, 1950, p.710-14. Neville BW, Damm DD, Allen CM, Bouquat JE. Oral and maxillofacial pathology. 3rd ed., St Louis: WB Saunders, 2009, p.832-33. Türkiye Endokrinoloji ve Metabolizma Derneği Hipofiz Çalışma Grubu hipofiz hastalıkları tanı tedavi ve izlem klavuzu.
- Ankara: TEMD, 2009, s.16-21. Hermann BL, Mortsch F, Berg C, Weischer T, Mohr C, Mann K. Acromegaly: a cross-sectional analysis of the oral and maxilofacial pathologies. Exp Clin Endocrinol
- Diabetes, 2011; 119: 9-14. Scully C, Cawson RA. Medical problems in dentistry. 3rd ed., Bristol: Wright, 1993, p.252-54. Öztürk A, Keskin A. Diş hekimliğinde tıbbi sorunlar. 4.bs., Ankara: Özyurt Ofset Matbaacılık, 1999, s.92-93.
- Sung SH, Yoon HD, Shon HS, Kim HT, Choi WY, Seo CJ, Lee JH. A case of Mc Cune –Albright syndrome with associated multiple endocrinopathies. Korean J Intern Med, 2007; 22(1): 45-50.
- Chanson P. Acromegaly. Presse Med, 2009; 38: 92-102.
- Grottoli S, Gasco V, Ragazzoni F, Chigo E. Hormonal diagnosis of GH hypersecrotory states. J Endocrinol Invest, 2003; 26: 27-35.
- Regezi JA, Sciubbas J. Oral pathology. Philladelphia: W.B Saunders, 1993, p.467-68.
- Karaalioğlu OF, Duymuş ZY. Prosthetic restoration of a patient with acromegaly: a case report. Atatürk Üniv Diş Hek Fak Derg, 2009; 19: 41-46.
- Sugata T, Myoken Y, Tanaka S. Acromegaly identified in a patient with a complaint of malocclusion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998; 85(1): 44Sacchi M, Cavagnini F. Acromegaly. Pituitary, 2006; 9(4): 297-303.
- Yalçın S,Yaltırık M. Temporo mandibuler eklem dislokasyon şikayeti ile müracat eden bir akromegali olgusu. Diş Hek Der, 1999; 32: 66-71.
- Dostalova S, Sonka K, Shamel Z, Weiss V, Marek J. Cephalometric asseessment of oral cranial abnormalities in patients with acromegaly. J Craniomaxillofac Surg, 2003; 31(2): 80-87.
- Künzler A, Farmand M. Typical changes in the viscerocranium in acromegaly. J Craniomaxillofac Surg, 1991; 19(8): 332Manetti L, Bogazzi F, Brogioni S, Grasso L, Lupi I, Genovesi M, Cennoni E, Gasperi M, Martino E. Submandibular salivary gland volume is increased in patients with acromegaly. Clin Endocrinol, 2002; 57(1) : 97-100. Mezosi E, Nemes O. Treatment of pituary adenomas. Orv Hetil, 2009; 150(39): 1803 Silverton SF. Endocrine disease. In: Greenberg MS, Glick M, editors. Burket’s oral medicine, diagnosis and treatment. 10th ed., Ontario: BC Decker Inc, 2003, p.578-83. Yazışma Adresi: Hümeyra KOCAELLİ
- İstanbul Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi A.D. 34093 Çapa-Fatih/İSTANBUL Tel: 212 414 20 20 e-posta: kocaelli@istanbul.edu.tr
Abstract
Akromegali, kemik ve yumuşak doku büyümeleri ile karakterize, yıllık insidansı bir milyonda üç
olan nadir hastalıktır. Bu değişiklikler anterior hipofiz bezi adenomu nedeniyle büyüme hormonunun
kronik hipersekresyonuna bağlı meydana gelir.
Akromegali tanısı alan hastalarda, transsfenoidal veya transfrontal cerrahi sonrası radyoterapi, diabet,
hipertansiyon, kardiopulmoner hastalıklar, uyku apnesi, kolon kanseri gibi sistemik rahatsızlıklar ve
kullandıkları ilaçlar dikkate alınmalıdır.
Akromegali sinsi gelişir, hastalığın başlangıcı ve tanısı arasındaki süre 6-10 yıla kadar uzayabilir.
Bu süreçte ekstremitelerdeki büyümeler, anlamsız baş ağrıları ve görme bozukluğu, gece terlemeleri,
prognati inferior, ön dişlerde protrüzyon, diastemalar, dudaklarda kalınlaşma, burun ve dilde büyümeler,
kondil hiperplazisi, edante hastaların protezlerindeki uyum sorunları akromegaliyi düşündürdüğünde,
endokrinolojik konsültasyonla İnsülin Benzeri Büyüme Faktörü I (Insuline Like Growth Factor I) seviyesi,
Oral Glikoz Tolerans Testi sırasında Büyüme Hormonu (Growth Hormon) ölçümü ve magnetik
resonans görüntüleme ile doğrulama erken teşhis için hayatidir. Akromegali olgularında kardiovasküler,
solunum hastalıkları ve malignansi nedeniyle mortalite oranı iki kat artar.
Keywords
References
- Kashyap RR, Babu GS, Shetty SR. Dental patient with acromegaly: a case report. J Oral Sci, 2011; 53(1): 133-36. Thoma KH. Oral pathology: a histological rontgenological and clinical study of diseases of the teeth, jaws and mouth. 4th ed., St. Louis: Mosby, 1950, p.710-14. Neville BW, Damm DD, Allen CM, Bouquat JE. Oral and maxillofacial pathology. 3rd ed., St Louis: WB Saunders, 2009, p.832-33. Türkiye Endokrinoloji ve Metabolizma Derneği Hipofiz Çalışma Grubu hipofiz hastalıkları tanı tedavi ve izlem klavuzu.
- Ankara: TEMD, 2009, s.16-21. Hermann BL, Mortsch F, Berg C, Weischer T, Mohr C, Mann K. Acromegaly: a cross-sectional analysis of the oral and maxilofacial pathologies. Exp Clin Endocrinol
- Diabetes, 2011; 119: 9-14. Scully C, Cawson RA. Medical problems in dentistry. 3rd ed., Bristol: Wright, 1993, p.252-54. Öztürk A, Keskin A. Diş hekimliğinde tıbbi sorunlar. 4.bs., Ankara: Özyurt Ofset Matbaacılık, 1999, s.92-93.
- Sung SH, Yoon HD, Shon HS, Kim HT, Choi WY, Seo CJ, Lee JH. A case of Mc Cune –Albright syndrome with associated multiple endocrinopathies. Korean J Intern Med, 2007; 22(1): 45-50.
- Chanson P. Acromegaly. Presse Med, 2009; 38: 92-102.
- Grottoli S, Gasco V, Ragazzoni F, Chigo E. Hormonal diagnosis of GH hypersecrotory states. J Endocrinol Invest, 2003; 26: 27-35.
- Regezi JA, Sciubbas J. Oral pathology. Philladelphia: W.B Saunders, 1993, p.467-68.
- Karaalioğlu OF, Duymuş ZY. Prosthetic restoration of a patient with acromegaly: a case report. Atatürk Üniv Diş Hek Fak Derg, 2009; 19: 41-46.
- Sugata T, Myoken Y, Tanaka S. Acromegaly identified in a patient with a complaint of malocclusion. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 1998; 85(1): 44Sacchi M, Cavagnini F. Acromegaly. Pituitary, 2006; 9(4): 297-303.
- Yalçın S,Yaltırık M. Temporo mandibuler eklem dislokasyon şikayeti ile müracat eden bir akromegali olgusu. Diş Hek Der, 1999; 32: 66-71.
- Dostalova S, Sonka K, Shamel Z, Weiss V, Marek J. Cephalometric asseessment of oral cranial abnormalities in patients with acromegaly. J Craniomaxillofac Surg, 2003; 31(2): 80-87.
- Künzler A, Farmand M. Typical changes in the viscerocranium in acromegaly. J Craniomaxillofac Surg, 1991; 19(8): 332Manetti L, Bogazzi F, Brogioni S, Grasso L, Lupi I, Genovesi M, Cennoni E, Gasperi M, Martino E. Submandibular salivary gland volume is increased in patients with acromegaly. Clin Endocrinol, 2002; 57(1) : 97-100. Mezosi E, Nemes O. Treatment of pituary adenomas. Orv Hetil, 2009; 150(39): 1803 Silverton SF. Endocrine disease. In: Greenberg MS, Glick M, editors. Burket’s oral medicine, diagnosis and treatment. 10th ed., Ontario: BC Decker Inc, 2003, p.578-83. Yazışma Adresi: Hümeyra KOCAELLİ
- İstanbul Üniversitesi Diş Hekimliği Fakültesi Ağız, Diş ve Çene Cerrahisi A.D. 34093 Çapa-Fatih/İSTANBUL Tel: 212 414 20 20 e-posta: kocaelli@istanbul.edu.tr
Details
| Primary Language | Turkish |
|---|---|
| Journal Section | Case Reports |
| Authors | |
| Publication Date | May 14, 2013 |
| Published in Issue | Year 2013 Volume: 47 Issue: 1 |
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