KLORHEKSİDİN İÇEREN BİR DİŞ MACUNUNUN ANTİ-PLAK AJAN İÇERMEYEN BİR DİŞ MACUNU İLE KARŞILAŞTIRILMASI: 16 GÜNLÜK KLİNİK ÇALIŞMA-A Comparison of a Chlorhexidine Dentfrice with a Conventional Dentfrice: A 16-Day Clinical Trial
Öz
öz
Amaç: Bu çalışmada klorheksidin (CHX) diglukonat içeren test macununu kontrol macunu ile karşılaştırılarak anti-plak ve anti-gingivitis etkinliğinin incelenmesi amaçlanmıştır.
Gereç ve Yöntem: Sistemik ve periodontal sağlıklı olan 20 gönüllü diş hekimliği öğrencisi dahil edilmiştir. Gönüllülere diş yüzeyi temizliği yapıldıktan sonra başlangıç indeksleri (plak indeksi, gingival indeks, ve leke indeksi) alınmıştır. Gönüllüler 16 gün boyunca 1. ve 3. segmenti test macunu ile 2. ve 4. segmenti ise kontrol macunu ile sabah ve akşam olmak üzere günde ikişer defa modifiye Bass tekniği kullanarak fırçalamışlardır. 16. günde indeksler tekrarlanmıştır.
Bulgular: Kontrol macunu ile fırçalanan segmentlerde plak indeks skorlarında daha fazla artış görülmüştür (p<0.05). Gingival indeks değerlerinde; test macunu ile fırçalanan segmentlerde azalma (p>0.05), kontrol macunu ile fırçalanan segmentlerde ise artış görülmüştür. 16. gündeki leke indeksi sonuçlarına göre test macununun diş lekelenmesini arttırdığı görülmüştür (p<0.05).
Sonuç: CHX içeren diş macunu antiplak ve antigingivitis etkinliğe sahiptir; ancak dişlerde leke gibi lokal yan etkilere yol açabilir.
Anahtar kelimeler: Klorheksidin, diş macunu, dental plak
ABSTRACT
Purpose: A test dentifrice with chlorhexidine digluconate compared with the control dentifrice and their anti-plaque and anti-gingivitis effects were examined.
Material and Methods: 20 volunteer periodontally and systemically healthy dental students were included. Plaque index, gingival index, and tooth staining index were measured at baseline and 16 days. Volunteers brushed 1. and 3. quadrants with the test paste and 2. and 4. segments with the control paste using Modified Bass technique for 16 days.
Results: There was significantly more plaque accumulation in the control group demonstrating CHX to be more efficient to prevent plaque accumulation (p<0.05). Gingival index scores were reduced in the test toothpaste (p>0.05), however there was an increase in the control toothpaste group at 16 day compared to baseline. Test paste caused an increased amount of staining (p<0.05).
Conclusion: Chlorhexidine containing toothpaste is more efficient to prevent plaque accumulation and gingivitis compared to a standard toothpaste. Staining is evident.
Keywords: Chlorhexidine, tooth paste, dental plaque
Anahtar Kelimeler
Kaynakça
- Frandsen A. Changing patterns of attitudes and oral health behaviour. Int Dent J, 1985; 35(4): 284-90. Yazıcıoğlu B, Şimşek I. Diş macunları nedir, ne değildir? TDBD, 1993; 21: 25-29. Axelsson P. Current role of pharmaceuticals in prevention of caries and periodontal disease. Int Dent J, 1993; 43(5): 473-82. Weinert W. “Oral hygiene products”
- In: Ullmann’s Encyclopedia of Industrial Chemistry. Germany: Wiley-VCH, 2000. doi:1002/14356007. a18_209. Schiott CR. Effect of chlorhexidine on the microflora of the oral cavity. J Periodontal Res, 1973; 8(suppl): 7-10. Roberts WR, Addy M. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. J Clin Periodontol, 1981; 8: 2953
- Lang NP, Hotz P, Graf H, Geering AH, Saxer UP, Sturzenberger Op, Meckel AH. Effects of supervised chlorhexidine mouthrinses in children. A longitudinal clinical trial. J Periodontal Res, 1982; 17: 101–111. Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000, 1997; 15: 55-62.
- Brecx M, Theilade J. Effect of chlorhexidine rinses on the morphology of early dental plaque formed on plastic film. J Clin Periodontal, 1984; 11: 553–64.
- Kornman KS. The rule of supragingival plaque in the prevention and treatment of periodontal disease. J Periodontal Res, 1986; 21: 5–22.
- Grossman E, Reiter G, Sturzenberger OP, De La Rosa M, Dickinson TD, Floretti Ga, Ludlam GE, Meckel AH. Six month study of the effects of a chlorhexidine mouthrinse on gingivitis in adults. J Periodontal Res, 1986; 21 Suppl 1 (S16): 33–43.
- Yates R, Jenkins S, Newcombe R, Wade W, Moran J, Addy M. A 6-month home usage trial of a 1% chlorhexidine toothpaste (1). Effects on plaque, gingivitis, calculus and toothstaining. J Clin Periodontol, 1993; 20(2): 130-38.
- Dolles OK, Gjermo P. Caries increment and gingival status during 2 years use of chlorhexidine and fluoride containing dentifrices. Scand J Dent Res, 1980; 88(1): 22–
- Johansen JR, Gjermo P, Eriksen HM. Effect of two years use of chlorhexidine -containing dentifrices on plaque, gingivitis and caries. Scand J Dent Res, 1975;83(5): 288–92.
- Jenkins S, Addy M, Newcombe R. The effects of a chlorhexidine toothpaste on the development of plaque, gingivitis and tooth staining. J Clin Periodontol, 1993; 20(1): 59-62. Rathe F, Auschill TM, Sculean A, Gaudszuhn Ch, Arweiler NB. The plaque and gingivitis reducing effect of a chlorhexidine and aluminium lactate containing dentifrice
- (Lacalut aktiv) over a period of 6 months. J Clin Periodontol, 2007; 34(8): 646-51. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta
- Odontol Scand, 1964; 22: 121-35. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence And Severity.
- Acta Odontol Scand, 1963; 21: 533-51. Claydon NC, Addy M, Adams G, Smith SR, Bosma ML, North M, Moran J.
- A comparison of two chlorhexidine gel brushing regimens and a conventional toothpaste brushing regimen for the development of tooth staining over a 6-week period. Int J Dent Hyg, 2006; 4(4): 183-88. Russell BG, Bay LM. Oral use of chlorhexidine gluconate toothpaste in epileptic children. Scand J Dent Res,1978; 86(1): 52- Olympio KP, Bardal PA, de M Bastos
- JR, Buzalaf MA. Effectiveness of a chlorhexidine dentifrice in orthodontic patients: a randomized-controlled trial. J Clin Periodontol, 2006; 33(6): 421-26. Löe H, Schiott CR. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res, 1970; 5(2): 79-83. Flötra L, Gjermo P, Rölla G, Waerhaug J. A 4-month study on the effect of chlorhexidine mouthwashes on 50 soldiers.
- Fasett, 1971; 6(4): 56-61. Flotra L. Different modes of chlorhexidine application and related local side effects. J Periodontal Res, 1973 Suppl; 12: 41Gjermo P. Chlorhexidine in dental practice. J Clin Periodontal, 1974; 1(3): 143
- Addy M, Wade WG, Jenkins S, Goodfield S. Comparison of two commercially available chlorhexidine mouthrinses: I. Staining and antimicrobial effects in vitro. Clin Prev Dent, 1989; 11(5): 10-14.
- Gürgan Ca, Zaim E, Bakirsoy I, Soykan E. Short-term side effects of 0.2% alchol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: a double-blind clinical study. J Periodontal, 2006; 77(3): 370-84. Yazışma Adresi: Emine ÇİFCİBAŞI
- İstanbul Üniversitesi Diş Hekimliği Fakültesi Periodontoloji A.D. Tel:414 20 20 e-posta:emineyek@hotmail.com
KLORHEKSİDİN İÇEREN BİR DİŞ MACUNUNUN ANTİ-PLAK AJAN İÇERMEYEN BİR DİŞ MACUNU İLE KARŞILAŞTIRILMASI: 16 GÜNLÜK KLİNİK ÇALIŞMA
Öz
Amaç: Bu çalışmada klorheksidin (CHX) diglukonat içeren test macununu kontrol macunu ile karşılaştırılarak anti-plak ve anti-gingivitis etkinliğinin incelenmesi amaçlanmıştır.Gereç ve Yöntem: Sistemik ve periodontal sağlıklı olan 20 gönüllü diş hekimliği öğrencisi dâhil edilmiştir. Gönüllülere diş yüzeyi temizliği yapıldıktan sonra başlangıç indeksleri (plak indeksi, gingival indeks, ve leke indeksi) alınmıştır. Gönüllüler 16 gün boyunca 1. ve 3. segmenti test macunu ile 2. ve 4. segmenti ise kontrol macunu ile sabah ve akşam olmak üzere günde ikişer defa modifiye Bass tekniği kullanarak fırçalamışlardır. 16. günde indeksler tekrarlanmıştır.Bulgular: Kontrol macunu ile fırçalanan segmentlerde plak indeks skorlarında daha fazla artış görülmüştür (p < 0.05). Gingival indeks değerlerinde; test macunu ile fırçalanan segmentlerde azalma (p > 0.05), kontrol macunu ile fırçalanan segmentlerde ise artış görülmüştür. 16. gündeki leke indeksi sonuçlarına göre test macununun diş lekelenmesini arttırdığı görülmüştür (p < 0.05).Sonuç: CHX içeren diş macunu antiplak ve antigingivitis etkinliğe sahiptir; ancak dişlerde leke gibi lokal yan etkilere yol açabilir.
Anahtar Kelimeler
Kaynakça
- Frandsen A. Changing patterns of attitudes and oral health behaviour. Int Dent J, 1985; 35(4): 284-90. Yazıcıoğlu B, Şimşek I. Diş macunları nedir, ne değildir? TDBD, 1993; 21: 25-29. Axelsson P. Current role of pharmaceuticals in prevention of caries and periodontal disease. Int Dent J, 1993; 43(5): 473-82. Weinert W. “Oral hygiene products”
- In: Ullmann’s Encyclopedia of Industrial Chemistry. Germany: Wiley-VCH, 2000. doi:1002/14356007. a18_209. Schiott CR. Effect of chlorhexidine on the microflora of the oral cavity. J Periodontal Res, 1973; 8(suppl): 7-10. Roberts WR, Addy M. Comparison of the in vivo and in vitro antibacterial properties of antiseptic mouthrinses containing chlorhexidine, alexidine, cetyl pyridinium chloride and hexetidine. Relevance to mode of action. J Clin Periodontol, 1981; 8: 2953
- Lang NP, Hotz P, Graf H, Geering AH, Saxer UP, Sturzenberger Op, Meckel AH. Effects of supervised chlorhexidine mouthrinses in children. A longitudinal clinical trial. J Periodontal Res, 1982; 17: 101–111. Jones CG. Chlorhexidine: is it still the gold standard? Periodontol 2000, 1997; 15: 55-62.
- Brecx M, Theilade J. Effect of chlorhexidine rinses on the morphology of early dental plaque formed on plastic film. J Clin Periodontal, 1984; 11: 553–64.
- Kornman KS. The rule of supragingival plaque in the prevention and treatment of periodontal disease. J Periodontal Res, 1986; 21: 5–22.
- Grossman E, Reiter G, Sturzenberger OP, De La Rosa M, Dickinson TD, Floretti Ga, Ludlam GE, Meckel AH. Six month study of the effects of a chlorhexidine mouthrinse on gingivitis in adults. J Periodontal Res, 1986; 21 Suppl 1 (S16): 33–43.
- Yates R, Jenkins S, Newcombe R, Wade W, Moran J, Addy M. A 6-month home usage trial of a 1% chlorhexidine toothpaste (1). Effects on plaque, gingivitis, calculus and toothstaining. J Clin Periodontol, 1993; 20(2): 130-38.
- Dolles OK, Gjermo P. Caries increment and gingival status during 2 years use of chlorhexidine and fluoride containing dentifrices. Scand J Dent Res, 1980; 88(1): 22–
- Johansen JR, Gjermo P, Eriksen HM. Effect of two years use of chlorhexidine -containing dentifrices on plaque, gingivitis and caries. Scand J Dent Res, 1975;83(5): 288–92.
- Jenkins S, Addy M, Newcombe R. The effects of a chlorhexidine toothpaste on the development of plaque, gingivitis and tooth staining. J Clin Periodontol, 1993; 20(1): 59-62. Rathe F, Auschill TM, Sculean A, Gaudszuhn Ch, Arweiler NB. The plaque and gingivitis reducing effect of a chlorhexidine and aluminium lactate containing dentifrice
- (Lacalut aktiv) over a period of 6 months. J Clin Periodontol, 2007; 34(8): 646-51. Silness J, Löe H. Periodontal disease in pregnancy. II. Correlation between oral hygiene and periodontal condition. Acta
- Odontol Scand, 1964; 22: 121-35. Löe H, Silness J. Periodontal disease in pregnancy. I. Prevalence And Severity.
- Acta Odontol Scand, 1963; 21: 533-51. Claydon NC, Addy M, Adams G, Smith SR, Bosma ML, North M, Moran J.
- A comparison of two chlorhexidine gel brushing regimens and a conventional toothpaste brushing regimen for the development of tooth staining over a 6-week period. Int J Dent Hyg, 2006; 4(4): 183-88. Russell BG, Bay LM. Oral use of chlorhexidine gluconate toothpaste in epileptic children. Scand J Dent Res,1978; 86(1): 52- Olympio KP, Bardal PA, de M Bastos
- JR, Buzalaf MA. Effectiveness of a chlorhexidine dentifrice in orthodontic patients: a randomized-controlled trial. J Clin Periodontol, 2006; 33(6): 421-26. Löe H, Schiott CR. The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man. J Periodontal Res, 1970; 5(2): 79-83. Flötra L, Gjermo P, Rölla G, Waerhaug J. A 4-month study on the effect of chlorhexidine mouthwashes on 50 soldiers.
- Fasett, 1971; 6(4): 56-61. Flotra L. Different modes of chlorhexidine application and related local side effects. J Periodontal Res, 1973 Suppl; 12: 41Gjermo P. Chlorhexidine in dental practice. J Clin Periodontal, 1974; 1(3): 143
- Addy M, Wade WG, Jenkins S, Goodfield S. Comparison of two commercially available chlorhexidine mouthrinses: I. Staining and antimicrobial effects in vitro. Clin Prev Dent, 1989; 11(5): 10-14.
- Gürgan Ca, Zaim E, Bakirsoy I, Soykan E. Short-term side effects of 0.2% alchol-free chlorhexidine mouthrinse used as an adjunct to non-surgical periodontal treatment: a double-blind clinical study. J Periodontal, 2006; 77(3): 370-84. Yazışma Adresi: Emine ÇİFCİBAŞI
- İstanbul Üniversitesi Diş Hekimliği Fakültesi Periodontoloji A.D. Tel:414 20 20 e-posta:emineyek@hotmail.com
Ayrıntılar
| Birincil Dil | İngilizce |
|---|---|
| Bölüm | Araştırmalar / Original Articles |
| Yazarlar | |
| Yayımlanma Tarihi | 12 Aralık 2013 |
| Yayımlandığı Sayı | Yıl 2013 Cilt: 47 Sayı: 3 |
Kaynak Göster
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