Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe

Ummahan Öz

doi:10.54187/jnrs.1522818

EN

Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe

Abstract

This study uses bioinformatics approaches to elucidate the genetic basis of secondary metabolite biosynthesis in Zingiber officinale (Z. officinale). To this end, it identifies 44 secondary metabolite biosynthetic gene clusters and maps onto individual chromosomes, with chromosomes 1A and 8A exhibiting higher concentrations. Here, protein homology modeling provided insights into the structural characteristics of terpene synthases and Cytochrome P450 enzymes, shedding light on their potential roles in stress response and secondary metabolite production. Moreover, the identification of enzymes, such as (-)-kolavenyl diphosphate synthase TPS28 and cytochrome P450 93A3-like, opens up new possibilities for investigating the intricate pathways involved in terpene diversity and stress response mechanisms within Z. officinale. This study highlights the importance of understanding the molecular mechanisms underlying plant-derived bioactive compounds for pharmaceutical applications.

Keywords

Bioinformatic, Gene cluster, Protein homology, Zingiber officinale

Ethical Statement

No approval from the Board of Ethics is required.

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Details

Primary Language

English

Subjects

Genomics and Transcriptomics

Journal Section

Research Article

Authors

Ummahan Öz ^*
0000-0002-0281-1048
Türkiye

Early Pub Date

August 30, 2024

Publication Date

August 31, 2024

Submission Date

July 26, 2024

Acceptance Date

August 26, 2024

Published in Issue

Year 2024 Volume: 13 Number: 2

DOI

https://doi.org/10.54187/jnrs.1522818

IZ

https://izlik.org/JA83GC82ZU

APA

Öz, U. (2024). Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe. Journal of New Results in Science, 13(2), 134-152. https://doi.org/10.54187/jnrs.1522818

AMA

1.Öz U. Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe. JNRS. 2024;13(2):134-152. doi:10.54187/jnrs.1522818

Chicago

Öz, Ummahan. 2024. “Genomic Analysis of Secondary Metabolite Biosynthesis Gene Clusters and Structural Characterization of Terpene Synthase and Cytochrome P450 Enzymes in Zingiber Officinale Roscoe”. Journal of New Results in Science 13 (2): 134-52. https://doi.org/10.54187/jnrs.1522818.

EndNote

Öz U (August 1, 2024) Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe. Journal of New Results in Science 13 2 134–152.

IEEE

[1]U. Öz, “Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe”, JNRS, vol. 13, no. 2, pp. 134–152, Aug. 2024, doi: 10.54187/jnrs.1522818.

ISNAD

Öz, Ummahan. “Genomic Analysis of Secondary Metabolite Biosynthesis Gene Clusters and Structural Characterization of Terpene Synthase and Cytochrome P450 Enzymes in Zingiber Officinale Roscoe”. Journal of New Results in Science 13/2 (August 1, 2024): 134-152. https://doi.org/10.54187/jnrs.1522818.

JAMA

1.Öz U. Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe. JNRS. 2024;13:134–152.

MLA

Öz, Ummahan. “Genomic Analysis of Secondary Metabolite Biosynthesis Gene Clusters and Structural Characterization of Terpene Synthase and Cytochrome P450 Enzymes in Zingiber Officinale Roscoe”. Journal of New Results in Science, vol. 13, no. 2, Aug. 2024, pp. 134-52, doi:10.54187/jnrs.1522818.

Vancouver

1.Ummahan Öz. Genomic analysis of secondary metabolite biosynthesis gene clusters and structural characterization of terpene synthase and cytochrome P450 enzymes in Zingiber officinale Roscoe. JNRS. 2024 Aug. 1;13(2):134-52. doi:10.54187/jnrs.1522818

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