Araştırma Makalesi
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Yıl 2019, Cilt: 8 Sayı: 1, 1 - 5, 15.12.2019

Öz

Kaynakça

  • Aksit, H., Çelik, S.M., Sen, Ö., Erenler, R., Demirtas, I., et al, 2014. Complete isolation and characterization of polar portion of Mentha dumetorum water extract. Rec Nat Prod, 8: 277-280.
  • Bayir, B., Gündüz, H., Usta, T., Şahin, E., Özdemir, Z., et al, 2014. Chemical Composition of Essential Oil from Marrubium Vulgare L. Leaves. J New Results Sci, 6: 44-50.
  • Demirtas, I., Erenler, R., Elmastas, M., Goktasoglu, A., 2013. Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chem, 136: 34-40.
  • Elmastas, M., Celik, S.M., Genc, N., Aksit, H., Erenler, R., Gulcin, İ., 2018. Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites. Int J Food Prop, 21: 374-384.
  • Elmastas, M., Erenler, R., Isnac, B., Aksit, H., Sen, O., et al, 2016. Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Nat Prod Res, 30: 299-304.
  • Elmastas, M., Ozturk, L., Gokce, I., Erenler, R., Aboul-Enein, H.Y., 2004. Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.). Anal Lett, 37: 1859-1869.
  • Elmastaş, M., Telci, İ., Akşit, H., Erenler, R., 2015. Comparison of total phenolic contents and antioxidant capacities in mint genotypes used as spices/Baharat olarak kullanılan nane genotiplerinin toplam fenolik içerikleri ve antioksidan kapasitelerinin karşılaştırılması. Turk J Biochem, 40: 456-462.
  • Erenler, R., Adak, T., Karan, T., Elmastas, M., Yildiz, I., et al, 2017a. Chemical Constituents isolated from Origanum solymicum with Antioxidant activities. The Eurasia Proceed Sci Tech Eng Math: 139-145.
  • Erenler, R., Demirtas, I., Karan, T., Altun, M., Gul, F., 2017b. Inhibitory Effect of 6, 7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro. Int J Sec Metabol, 4: 512-516.
  • Erenler, R., Demirtas, I., Karan, T., Gul, F., Kayir, O., Karakoc, O.C., 2018a. Chemical constituents, quantitative analysis and insecticidal activities of plant extract and essential oil from Origanum onites L. Trends Phytochem Research, 2: 91-96.
  • Erenler, R., Meral, B., Sen, O., Elmastas, M., Aydin, A., et al, 2017c. Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. Pharm Biol, 55: 1646-1653.
  • Erenler, R., Pabuccu, K., Yaglioglu, A.S., Demirtas, I., Gul, F., 2016a. Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines. Z Naturforsch C, 71: 87-92.
  • Erenler, R., Sen, O., Aksit, H., Demirtas, I., Yaglioglu, A.S., et al, 2016b. Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. J Sci Food Agr, 96: 822-836.
  • Erenler, R., Sen, O., Yaglioglu, A.S., Demirtas, I., 2016c. Bioactivity-guided isolation of antiproliferative sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis. Comb Chem High Throughput Screen, 19: 66-72.
  • Erenler, R., Sen, O., Yildiz, I., Aydin, A., 2016d. Antiproliferative activities of chemical constituents isolated from Thymus praecox subsp grossheimii (Ronniger) Jalas. Rec Nat Prod, 10: 766-770.
  • Erenler, R., Telci, İ., Elmastaş, M., Akşit, H., Gül, F., et al, 2018b. Quantification of flavonoids isolated from Mentha spicata in selected clones of Turkish mint landraces. Turk J Chem, 42: 1695-1705.
  • Erenler, R., Telci, I., Ulutas, M., Demirtas, I., Gul, F., et al, 2015. Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. J Food Biochem, 39: 622-630.
  • Erenler, R., Yilmaz, S., Aksit, H., Sen, O., Genc, N., et al, 2014. Antioxidant activities of chemical constituents isolated from Echinops orientalis Trauv. Rec Nat Prod, 8: 32.
  • Geerlings, P., De Proft, F., Langenaeker, W., 2003. Conceptual density functional theory. Chemical reviews, 103: 1793-1874.
  • Genç, N., Yıldız, İ., Karan, T., Eminağaoğlu, Ö., Erenler, R., 2019. Antioxidant activity and total phenolic contents of Galanthus woronowii (Amaryllidaceae). Turk J Biodiv, 2: 1-5.
  • Gökalp, F., Erenler, R., 2018. Theoretical study of synthesis of 1,3-dibromonaphthanlene. J Chem Soc Pakistan, 40: 1089-1092.
  • Guzel, A., Aksit, H., Elmastas, M., Erenler, R., 2017. Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden. and Scheng. Pharmacogn Mag, 13: 316.
  • Iranshahi, M., Rezaee, R., Parhiz, H., Roohbakhsh, A., Soltani, F., 2015. Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin. Life sciences, 137: 125-132.
  • Karan, T., Erenler, R., 2017. Screening of norharmane from seven cyanobacteria by high-performance liquid chromatography. Pharmacogn Mag, 13: 723-725.
  • Karan, T., Erenler, R., 2018. Fatty acid constituents and anticancer activity of Cladophora fracta (OF Müller ex Vahl) Kützing. Trop J Pharm Res, 17: 1977-1982.
  • Karan, T., Gokalp, F., Erenler, R., 2018. Theoretical Study on Flavonoids Isolated from Allium vineale. Cumhur Sci J, 39: 66-70.
  • Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., et al, 2016. Quercetin, inflammation, and immunity. Nutrients, 8: 167.
  • Lin, J., Teo, L.M., Leong, L.P., Zhou, W., 2019. In vitro bioaccessibility and bioavailability of quercetin from the quercetin-fortified bread products with reduced glycemic potential. Food Chem, 286: 629-635.
  • Tanak, H., 2010. Quantum chemical computational studies on 2-methyl-6-[2-(trifluoromethyl) phenyliminomethyl] phenol. J Mol Struct: Theochem, 950: 5-12.

Theoretical Study of Quercetin Derivatives

Yıl 2019, Cilt: 8 Sayı: 1, 1 - 5, 15.12.2019

Öz

Kuesetin,
birçok bitkiden izole edilen, çok sayıda biyolojik aktivite gösteren önemli bir
doğal üründür. Doğal ürünler, formakolojik etkilerini güçlendirmek için
foksiyonel hale getirilir. Bundan dolayı, en aktif bileşiği ortaya koymak için,
kuersetin türevlendirilerek teorik hesaplamalar yapıldı. Ayrıca, bu çalışma
aktif ve hedef bileşiklerin sentezi için sentetik kimyacılara ilham verecektir.
Kuersetin türevlerinin kimyasal özellikleri teorik olarak araştırıldı.
Bileşiklerin kuantum hesaplamaları, B3lyp/6-31+g(d,p) metoduyla yapıldı.
Bileşik 6 en kararlı bileşik olarak
belirlendi. İnstenilen reaksiyonlar için ve vucudaki dokuya ulaşması bakımından
bu bileşik diğerlerine nazaran daha üstündür. Bileşik 3’ün yüksek polaritesinden dolayı, kanda çözünebilme ve farmasötik
endüstrisinde kullanılabilme potansiyeli vardır.

Kaynakça

  • Aksit, H., Çelik, S.M., Sen, Ö., Erenler, R., Demirtas, I., et al, 2014. Complete isolation and characterization of polar portion of Mentha dumetorum water extract. Rec Nat Prod, 8: 277-280.
  • Bayir, B., Gündüz, H., Usta, T., Şahin, E., Özdemir, Z., et al, 2014. Chemical Composition of Essential Oil from Marrubium Vulgare L. Leaves. J New Results Sci, 6: 44-50.
  • Demirtas, I., Erenler, R., Elmastas, M., Goktasoglu, A., 2013. Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chem, 136: 34-40.
  • Elmastas, M., Celik, S.M., Genc, N., Aksit, H., Erenler, R., Gulcin, İ., 2018. Antioxidant activity of an anatolian herbal tea—Origanum minutiflorum: isolation and characterization of its secondary metabolites. Int J Food Prop, 21: 374-384.
  • Elmastas, M., Erenler, R., Isnac, B., Aksit, H., Sen, O., et al, 2016. Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Nat Prod Res, 30: 299-304.
  • Elmastas, M., Ozturk, L., Gokce, I., Erenler, R., Aboul-Enein, H.Y., 2004. Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.). Anal Lett, 37: 1859-1869.
  • Elmastaş, M., Telci, İ., Akşit, H., Erenler, R., 2015. Comparison of total phenolic contents and antioxidant capacities in mint genotypes used as spices/Baharat olarak kullanılan nane genotiplerinin toplam fenolik içerikleri ve antioksidan kapasitelerinin karşılaştırılması. Turk J Biochem, 40: 456-462.
  • Erenler, R., Adak, T., Karan, T., Elmastas, M., Yildiz, I., et al, 2017a. Chemical Constituents isolated from Origanum solymicum with Antioxidant activities. The Eurasia Proceed Sci Tech Eng Math: 139-145.
  • Erenler, R., Demirtas, I., Karan, T., Altun, M., Gul, F., 2017b. Inhibitory Effect of 6, 7-dimethoxy-5-hydroxyflavone on Human Cervix Carcinoma in Vitro. Int J Sec Metabol, 4: 512-516.
  • Erenler, R., Demirtas, I., Karan, T., Gul, F., Kayir, O., Karakoc, O.C., 2018a. Chemical constituents, quantitative analysis and insecticidal activities of plant extract and essential oil from Origanum onites L. Trends Phytochem Research, 2: 91-96.
  • Erenler, R., Meral, B., Sen, O., Elmastas, M., Aydin, A., et al, 2017c. Bioassay-guided isolation, identification of compounds from Origanum rotundifolium and investigation of their antiproliferative and antioxidant activities. Pharm Biol, 55: 1646-1653.
  • Erenler, R., Pabuccu, K., Yaglioglu, A.S., Demirtas, I., Gul, F., 2016a. Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines. Z Naturforsch C, 71: 87-92.
  • Erenler, R., Sen, O., Aksit, H., Demirtas, I., Yaglioglu, A.S., et al, 2016b. Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. J Sci Food Agr, 96: 822-836.
  • Erenler, R., Sen, O., Yaglioglu, A.S., Demirtas, I., 2016c. Bioactivity-guided isolation of antiproliferative sesquiterpene lactones from Centaurea solstitialis L. ssp. solstitialis. Comb Chem High Throughput Screen, 19: 66-72.
  • Erenler, R., Sen, O., Yildiz, I., Aydin, A., 2016d. Antiproliferative activities of chemical constituents isolated from Thymus praecox subsp grossheimii (Ronniger) Jalas. Rec Nat Prod, 10: 766-770.
  • Erenler, R., Telci, İ., Elmastaş, M., Akşit, H., Gül, F., et al, 2018b. Quantification of flavonoids isolated from Mentha spicata in selected clones of Turkish mint landraces. Turk J Chem, 42: 1695-1705.
  • Erenler, R., Telci, I., Ulutas, M., Demirtas, I., Gul, F., et al, 2015. Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. J Food Biochem, 39: 622-630.
  • Erenler, R., Yilmaz, S., Aksit, H., Sen, O., Genc, N., et al, 2014. Antioxidant activities of chemical constituents isolated from Echinops orientalis Trauv. Rec Nat Prod, 8: 32.
  • Geerlings, P., De Proft, F., Langenaeker, W., 2003. Conceptual density functional theory. Chemical reviews, 103: 1793-1874.
  • Genç, N., Yıldız, İ., Karan, T., Eminağaoğlu, Ö., Erenler, R., 2019. Antioxidant activity and total phenolic contents of Galanthus woronowii (Amaryllidaceae). Turk J Biodiv, 2: 1-5.
  • Gökalp, F., Erenler, R., 2018. Theoretical study of synthesis of 1,3-dibromonaphthanlene. J Chem Soc Pakistan, 40: 1089-1092.
  • Guzel, A., Aksit, H., Elmastas, M., Erenler, R., 2017. Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden. and Scheng. Pharmacogn Mag, 13: 316.
  • Iranshahi, M., Rezaee, R., Parhiz, H., Roohbakhsh, A., Soltani, F., 2015. Protective effects of flavonoids against microbes and toxins: The cases of hesperidin and hesperetin. Life sciences, 137: 125-132.
  • Karan, T., Erenler, R., 2017. Screening of norharmane from seven cyanobacteria by high-performance liquid chromatography. Pharmacogn Mag, 13: 723-725.
  • Karan, T., Erenler, R., 2018. Fatty acid constituents and anticancer activity of Cladophora fracta (OF Müller ex Vahl) Kützing. Trop J Pharm Res, 17: 1977-1982.
  • Karan, T., Gokalp, F., Erenler, R., 2018. Theoretical Study on Flavonoids Isolated from Allium vineale. Cumhur Sci J, 39: 66-70.
  • Li, Y., Yao, J., Han, C., Yang, J., Chaudhry, M., et al, 2016. Quercetin, inflammation, and immunity. Nutrients, 8: 167.
  • Lin, J., Teo, L.M., Leong, L.P., Zhou, W., 2019. In vitro bioaccessibility and bioavailability of quercetin from the quercetin-fortified bread products with reduced glycemic potential. Food Chem, 286: 629-635.
  • Tanak, H., 2010. Quantum chemical computational studies on 2-methyl-6-[2-(trifluoromethyl) phenyliminomethyl] phenol. J Mol Struct: Theochem, 950: 5-12.
Toplam 29 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Articles
Yazarlar

Ramazan Erenler 0000-0002-0505-3190

Faik Gokalp 0000-0003-4363-3839

Yayımlanma Tarihi 15 Aralık 2019
Yayımlandığı Sayı Yıl 2019 Cilt: 8 Sayı: 1

Kaynak Göster

APA Erenler, R., & Gokalp, F. (2019). Theoretical Study of Quercetin Derivatives. Journal of New Results in Science, 8(1), 1-5.
AMA Erenler R, Gokalp F. Theoretical Study of Quercetin Derivatives. JNRS. Aralık 2019;8(1):1-5.
Chicago Erenler, Ramazan, ve Faik Gokalp. “Theoretical Study of Quercetin Derivatives”. Journal of New Results in Science 8, sy. 1 (Aralık 2019): 1-5.
EndNote Erenler R, Gokalp F (01 Aralık 2019) Theoretical Study of Quercetin Derivatives. Journal of New Results in Science 8 1 1–5.
IEEE R. Erenler ve F. Gokalp, “Theoretical Study of Quercetin Derivatives”, JNRS, c. 8, sy. 1, ss. 1–5, 2019.
ISNAD Erenler, Ramazan - Gokalp, Faik. “Theoretical Study of Quercetin Derivatives”. Journal of New Results in Science 8/1 (Aralık 2019), 1-5.
JAMA Erenler R, Gokalp F. Theoretical Study of Quercetin Derivatives. JNRS. 2019;8:1–5.
MLA Erenler, Ramazan ve Faik Gokalp. “Theoretical Study of Quercetin Derivatives”. Journal of New Results in Science, c. 8, sy. 1, 2019, ss. 1-5.
Vancouver Erenler R, Gokalp F. Theoretical Study of Quercetin Derivatives. JNRS. 2019;8(1):1-5.


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