Examination of the possible effects of ozone application in Duchenne muscular dystrophy

Yıl 2024, Cilt: 3 Sayı: 1, 8 - 13, 29.03.2024

Zeynep Yüce Yasan

Öz

Duchenne muscular dystrophy (DMD), an X-linked disorder, has an incidence of one in 5000 boys and presents in early childhood with proximal muscle weakness. The disease is caused by mutations in DMD (encoding dystrophin) that abolish the production of dystrophin in muscle. In this study, we aimed to investigate the effect of ozone therapy (OT) on muscle oxygenation in DMD patients. For this purpose, DMD was developed in the primary skeletal muscle cell line. The changes that occurred by administering OT to the cell lines were observed. OT reduced mitochondrial ROS caused by DMD, partially improved the shape changes in myoblasts, but had no effect on dystrophin. OT to DMD patients may have a positive effect on muscle cells.

Anahtar Kelimeler

Duchenne muscular dystrophy, mitochondrial ROS, ozone therapy

Kaynakça

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