SYNTHESIS, CHARACTERIZATION, UREASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF SOME CHIRAL PYRAZOLO DERIVATIVES

Year 2017, , 32 - 49, 01.06.2017

Yusuf Sıcak Said Nadeem Bedriye Seda Kurşun Aktar Emine Elçin Oruç Emre Mehmet Öztürk Ayşegül Karaküçük İyidoğan Mehmet Ali Özler İbrahim Demirtaş

https://doi.org/10.5281/zenodo.3768580

Abstract

A series of some pyrazolo derivatives a-f were synthesized and their urease inhibitory and tyrosinase inhibitory activities were evaluated. Among synthesized compounds, 2f, 2e, 1f, 2d, 1e, 2b, and 1d showed excellent activities IC50 i.e. 11.73±0.28, 14.21±0.56, 15.37±0.89, 17.66±0.82, 18.64±0.19, 19.55±0.39, and 22.08±0.96 µM, respectively. According to tyrosinase assay results, compound 2f showed the good tyrosinase inhibitory activity i.e. 6.12±0.40 mM of IC50

Keywords

Pyrrolidine, chiral, thiazolidine-2, 4-one, 2-thioxothiazolidin-4-one, pyrazolo, urease inhibitory activity, tyrosinase inhibitory activity

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