BibTex RIS Kaynak Göster
Yıl 2017, Cilt: 3 Sayı: 1, 22 - 31, 01.06.2017
https://doi.org/10.5281/zenodo.3768634

Öz

Kaynakça

  • [1] Atta-ur-Rahman, S. Nasim, I. Baig, S. Jalil, I. Orhan, B. Sener, M.I. Choudhary, Antiinflammatory isoflavonoids from the rhizomes of Iris germanica, J Ethnopharmacol, 86 (2003) 177-180
  • [2] I. Orhan, S. Nasim, B. Şener, F. Ayanoğlu, M. Özgüven, M.I. Choudhary,.Atta-ur-Rahman, Two isoflavones and bioactivity spectrum of the crude extracts of Iris germanica rhizomes, Phytoter Res, 17 (2003) 575-577
  • [3] Y. Akyol, K. Yetişen, C. Özdemir, Morphological and anatomical studies of Iris iberica subsp. elegantissima and Iris sintenisii (Iridaceae) from Turkey, Phytol Balcan, 20 (2014) 71–77
  • [4] P.H. Davis, Flora of Turkey and East Aegean Islands, University Press: Edinburgh, 8 (1984) 382-412
  • [5] Y. Miyake, H. Ito, T. Yoshida, Identification of iridals as piscicidal components of Iridaceous plants and their conformations associated with CD spectra, Canad J Chem, 75 (1997) 734-741
  • [6] K. Takahashi, Y. Hano, M. Suganuma, S. Okabe, T. Nomura, 28-Deacetylbelamcandal, a tumor-promoting triterpenoid from Iris tectorum, J Nat Prod, 62 (1999) 291-293
  • [7] S.M. Wong, J.M. Pezzuto, H.H. Fong, N.R. Farnsworth, Isolation, structural elucidation, and chemical synthesis of 2-hydroxy-3-octadecyl-5-methoxy-1,4-benzoquinone (irisoquin), a cytotoxic constituent of Iris missouriensis, J Pharmaceutical Sci, 74 (1985) 1114-1116
  • [8] Wong, S.M., Oshima, Y., Pezzuto, J.M., Fong, H.H., Farnsworth, N.R. Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae), J Pharmaceutical Sci, 75 (1986) 317-320
  • [9] Y. Muto, H. Ichikawa, O. Kitagawa, K. Kumagai, M. Watanabe, E. Ogawa, M. Seiki, Y. Shirataki, I. Yokoe, M. Komatsu, Studies on antiulcer agents. I. The effects of various methanol and aqueous extracts of crude drugs on antiulcer activity, Yakugaku Zasshi, 114 (1994) 980-984
  • [10] Y. Muto, H. Ichikawa, M. Seiki, Y. Shirataki, I. Yokoe, M. Komatsu, Studies on antiulcer agents. II. Synthesis and antiulcer activity of phenylpropanol derivatives, Yakugaku Zasshi, 114 (1994) 995-1004
  • [11] K. Takahashi, M. Ishino, Y. Hoshino, Y. Tokumaru, S. Suzuki, Study of Iridaceae plants with the capability to induce differentiation of HL-60 promylelocytic leukemia cells, Yakugaku Zasshi, 113 (1993) 647-654
  • [12] M. Jacobson, R.E. Redfern, G.D. Mills, Naturally occurring insect growth regulators. II. Screening of insect and plant extracts as insect juvenile hormone mimics, Lloydia, 38 (1975) 455-472
  • [13] R. Han, Highlight on the studies of anticancer drugs derived from plants in China, Stem Cells (Dayt), 12 (1994) 53-63
  • [14] Baytop, T. Türkiye’de Bitkilerle Tedavi. Istanbul University, Pharmacy Faculty Publication No.40, Virtual Printing, 1984, 384
  • [15] M. Antolovich, P.D. Prenzler, E. Patsalides, S. McDonald, K. Robards, Methods for testing antioxidant activity, Analyst, 127 (2002) 183-198
  • [16] J.M.C. Gutteridge, Biological origin of free radicals, and mechanisms of antioxidant protection, Chem-Biol Interac, 91 (1994) 133
  • [17] T.P.A. Devasagaym, J.C. Tilak, K.K. Boloor, K.S. Sane, S.S. Ghaskadbi, R.D. Lele, Review: Free radical and antioxidants in human health, Curr Stat Fut Pros JAPI, 53 (2004) 794-804
  • [18] Atta-ur-Rahman, MI Choudhary. Bioactive natural products as a potential source of new pharmacophores. A theory of memory, Pure Appl Chem, 73 (2001) 555-60
  • [19] I. Parveen, M.D. Threadgill, J.M. Moorby, A. Winters, Oxidative phenols in forage crops containing polyphenol oxidase enzymes, J Agric Food Chem, 58 (2010) 1371-1382
  • [20] M.T.H. Khan, Novel tyrosinase inhibitors from natural resources-their computational studies, Curr Med Chem, 19 (2012) 2262-2272
  • [21] K. Bao, Y. Dai, Z.B. Zhu, F.J. Tu, W.G. Zhang, X.S. Yao, Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors, Bioorg Med Chem, 18 (2010) 6708-6714
  • [22] Y.J. Kim, H. Uyama, Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future, Cell Mol Life Sci, 62 (2005) 1707- 1723
  • [23] F. Solano, S. Briganti, M. Picardo, G.H. Ghanem, Hypopigmenting agents: an updated review on biological, chemical and clinical aspects, Pigment Cell Melanoma Res, 19 (2006) 550-571
  • [24] T.S. Chang, An updated review of tyrosinase inhibitor, Int J Mol Sci, 10 (2009) 2440-2475
  • [25] I. Hacıbekiroğlu, U. Kolak, Screening antioxidant and anticholinesterase potential of Iris albicans extracts, Arabian J Chem, 8 (2012) 264-268
  • [26] N. Nazir, S. Koul, M.A. Qurishi, , S.C. Taneja, G.N. Qazi, Lipase-catalyzed regioselective protection/deprotection of hydroxyl groups of the isoflavone irilone isolated from Iris germanica, Biocatal Biotransform, 27 (2009) 118-123
  • [27] G. Deng, H. Zhang, H. Xue, S. Chen, X. Chen, Chemical Composition and Biological Activities of Essential Oil from the Rhizomes of Iris bulleyana, Agric Sci China, 8 (2009) 691-696
  • [28] P. Shoukat, K. Moonkyu, C. Hwan-Suck, B. Hyunsu, Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries, Phytoter Res, 21 (2007) 805-816
  • [29] R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, C. Rice-Evans, Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Rad Bio Med, 26 (1989) 1231-1237
  • [30] G.J. Marco, A rapid method for evaluation of antioxidants, J American Oil Chem Soc, 45 (1968) 594-598
  • [31] M. Öztürk, U. Kolak, G. Topçu, S. Öksüz, M.I. Choudhary, Antioxidant and anticholinesterase active constituents from Micromeria cilicica by radical-scavenging activity-guided fractionation, Food Chem, 126 (2011) 31-38
  • [32] R. Apak, K. Güçlü, M. Özyürek, S.E. Karademir, Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, Using their cupric ion reducing capacity in the presence of neocuproine: Cuprac Method, J Agric Food Chem, 52 (2004) 7970-7981
  • [33] M.S. Blois, Antioxidant determinations by the use of a stable free radical. Nature, 181 (1958) 1199-1200
  • [34] G.L. Ellman, K.D. Courtney, V. Andres, R.M. Featherstone, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol Behaivor, 7 (1961) 88- 95
  • [35] S. Khatib, O. Nerya, R. Musa, M. Shumel, S. Tamir, J. Vaya, Chalcones as Potent Tyrosinase Inhibitors: The Importance of 2,4-disubstituted Resorcinol Moiety, Bioorg Med Chem, 13 (13) 433-441

ANTIOXIDANT, ANTICHOLINESTERASE INHIBITORY AND TYROSINASE INHIBITORY ACTIVITIES OF IRIS XANTHOSPURIA EXTRACTS GROWING IN KÖYCEĞIZ REGION

Yıl 2017, Cilt: 3 Sayı: 1, 22 - 31, 01.06.2017
https://doi.org/10.5281/zenodo.3768634

Öz

This study was aimed to investigate antioxidant, anticholinesterase inhibitory and tyrosinase inhibitory activities of n-Hex, DCM, EtOAc, and n-BuOH extracts obtained from rhizome and stem of Iris xanthospuria. Generally, it exhibited the best activity in both antioxidant activity tests of the rhizome and stem EtOAc extracts of the plant. EtOAc extracts reflected moderate activity on butyrylcholinesterase enzyme in BChE assay. EtOAc extract of rhizome showed the good tyrosinase inhibitory activity IC50 value of 4.30±0.25 g/L. In this study, EtOAc extracts may be potentially a source of natural antioxidant, anticholinesterase inhibitory and tyrosinase inhibitory activities

Kaynakça

  • [1] Atta-ur-Rahman, S. Nasim, I. Baig, S. Jalil, I. Orhan, B. Sener, M.I. Choudhary, Antiinflammatory isoflavonoids from the rhizomes of Iris germanica, J Ethnopharmacol, 86 (2003) 177-180
  • [2] I. Orhan, S. Nasim, B. Şener, F. Ayanoğlu, M. Özgüven, M.I. Choudhary,.Atta-ur-Rahman, Two isoflavones and bioactivity spectrum of the crude extracts of Iris germanica rhizomes, Phytoter Res, 17 (2003) 575-577
  • [3] Y. Akyol, K. Yetişen, C. Özdemir, Morphological and anatomical studies of Iris iberica subsp. elegantissima and Iris sintenisii (Iridaceae) from Turkey, Phytol Balcan, 20 (2014) 71–77
  • [4] P.H. Davis, Flora of Turkey and East Aegean Islands, University Press: Edinburgh, 8 (1984) 382-412
  • [5] Y. Miyake, H. Ito, T. Yoshida, Identification of iridals as piscicidal components of Iridaceous plants and their conformations associated with CD spectra, Canad J Chem, 75 (1997) 734-741
  • [6] K. Takahashi, Y. Hano, M. Suganuma, S. Okabe, T. Nomura, 28-Deacetylbelamcandal, a tumor-promoting triterpenoid from Iris tectorum, J Nat Prod, 62 (1999) 291-293
  • [7] S.M. Wong, J.M. Pezzuto, H.H. Fong, N.R. Farnsworth, Isolation, structural elucidation, and chemical synthesis of 2-hydroxy-3-octadecyl-5-methoxy-1,4-benzoquinone (irisoquin), a cytotoxic constituent of Iris missouriensis, J Pharmaceutical Sci, 74 (1985) 1114-1116
  • [8] Wong, S.M., Oshima, Y., Pezzuto, J.M., Fong, H.H., Farnsworth, N.R. Plant anticancer agents XXXIX: Triterpenes from Iris missouriensis (Iridaceae), J Pharmaceutical Sci, 75 (1986) 317-320
  • [9] Y. Muto, H. Ichikawa, O. Kitagawa, K. Kumagai, M. Watanabe, E. Ogawa, M. Seiki, Y. Shirataki, I. Yokoe, M. Komatsu, Studies on antiulcer agents. I. The effects of various methanol and aqueous extracts of crude drugs on antiulcer activity, Yakugaku Zasshi, 114 (1994) 980-984
  • [10] Y. Muto, H. Ichikawa, M. Seiki, Y. Shirataki, I. Yokoe, M. Komatsu, Studies on antiulcer agents. II. Synthesis and antiulcer activity of phenylpropanol derivatives, Yakugaku Zasshi, 114 (1994) 995-1004
  • [11] K. Takahashi, M. Ishino, Y. Hoshino, Y. Tokumaru, S. Suzuki, Study of Iridaceae plants with the capability to induce differentiation of HL-60 promylelocytic leukemia cells, Yakugaku Zasshi, 113 (1993) 647-654
  • [12] M. Jacobson, R.E. Redfern, G.D. Mills, Naturally occurring insect growth regulators. II. Screening of insect and plant extracts as insect juvenile hormone mimics, Lloydia, 38 (1975) 455-472
  • [13] R. Han, Highlight on the studies of anticancer drugs derived from plants in China, Stem Cells (Dayt), 12 (1994) 53-63
  • [14] Baytop, T. Türkiye’de Bitkilerle Tedavi. Istanbul University, Pharmacy Faculty Publication No.40, Virtual Printing, 1984, 384
  • [15] M. Antolovich, P.D. Prenzler, E. Patsalides, S. McDonald, K. Robards, Methods for testing antioxidant activity, Analyst, 127 (2002) 183-198
  • [16] J.M.C. Gutteridge, Biological origin of free radicals, and mechanisms of antioxidant protection, Chem-Biol Interac, 91 (1994) 133
  • [17] T.P.A. Devasagaym, J.C. Tilak, K.K. Boloor, K.S. Sane, S.S. Ghaskadbi, R.D. Lele, Review: Free radical and antioxidants in human health, Curr Stat Fut Pros JAPI, 53 (2004) 794-804
  • [18] Atta-ur-Rahman, MI Choudhary. Bioactive natural products as a potential source of new pharmacophores. A theory of memory, Pure Appl Chem, 73 (2001) 555-60
  • [19] I. Parveen, M.D. Threadgill, J.M. Moorby, A. Winters, Oxidative phenols in forage crops containing polyphenol oxidase enzymes, J Agric Food Chem, 58 (2010) 1371-1382
  • [20] M.T.H. Khan, Novel tyrosinase inhibitors from natural resources-their computational studies, Curr Med Chem, 19 (2012) 2262-2272
  • [21] K. Bao, Y. Dai, Z.B. Zhu, F.J. Tu, W.G. Zhang, X.S. Yao, Design and synthesis of biphenyl derivatives as mushroom tyrosinase inhibitors, Bioorg Med Chem, 18 (2010) 6708-6714
  • [22] Y.J. Kim, H. Uyama, Tyrosinase inhibitors from natural and synthetic sources: structure, inhibition mechanism and perspective for the future, Cell Mol Life Sci, 62 (2005) 1707- 1723
  • [23] F. Solano, S. Briganti, M. Picardo, G.H. Ghanem, Hypopigmenting agents: an updated review on biological, chemical and clinical aspects, Pigment Cell Melanoma Res, 19 (2006) 550-571
  • [24] T.S. Chang, An updated review of tyrosinase inhibitor, Int J Mol Sci, 10 (2009) 2440-2475
  • [25] I. Hacıbekiroğlu, U. Kolak, Screening antioxidant and anticholinesterase potential of Iris albicans extracts, Arabian J Chem, 8 (2012) 264-268
  • [26] N. Nazir, S. Koul, M.A. Qurishi, , S.C. Taneja, G.N. Qazi, Lipase-catalyzed regioselective protection/deprotection of hydroxyl groups of the isoflavone irilone isolated from Iris germanica, Biocatal Biotransform, 27 (2009) 118-123
  • [27] G. Deng, H. Zhang, H. Xue, S. Chen, X. Chen, Chemical Composition and Biological Activities of Essential Oil from the Rhizomes of Iris bulleyana, Agric Sci China, 8 (2009) 691-696
  • [28] P. Shoukat, K. Moonkyu, C. Hwan-Suck, B. Hyunsu, Naturally occurring tyrosinase inhibitors: mechanism and applications in skin health, cosmetics and agriculture industries, Phytoter Res, 21 (2007) 805-816
  • [29] R. Re, N. Pellegrini, A. Proteggente, A. Pannala, M. Yang, C. Rice-Evans, Antioxidant activity applying an improved ABTS radical cation decolorization assay, Free Rad Bio Med, 26 (1989) 1231-1237
  • [30] G.J. Marco, A rapid method for evaluation of antioxidants, J American Oil Chem Soc, 45 (1968) 594-598
  • [31] M. Öztürk, U. Kolak, G. Topçu, S. Öksüz, M.I. Choudhary, Antioxidant and anticholinesterase active constituents from Micromeria cilicica by radical-scavenging activity-guided fractionation, Food Chem, 126 (2011) 31-38
  • [32] R. Apak, K. Güçlü, M. Özyürek, S.E. Karademir, Novel total antioxidant capacity index for dietary polyphenols and vitamins C and E, Using their cupric ion reducing capacity in the presence of neocuproine: Cuprac Method, J Agric Food Chem, 52 (2004) 7970-7981
  • [33] M.S. Blois, Antioxidant determinations by the use of a stable free radical. Nature, 181 (1958) 1199-1200
  • [34] G.L. Ellman, K.D. Courtney, V. Andres, R.M. Featherstone, A new and rapid colorimetric determination of acetylcholinesterase activity, Biochem Pharmacol Behaivor, 7 (1961) 88- 95
  • [35] S. Khatib, O. Nerya, R. Musa, M. Shumel, S. Tamir, J. Vaya, Chalcones as Potent Tyrosinase Inhibitors: The Importance of 2,4-disubstituted Resorcinol Moiety, Bioorg Med Chem, 13 (13) 433-441
Toplam 35 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Bölüm Research Article
Yazarlar

Yusuf Sıcak Bu kişi benim

Halit Büyüksakallı Bu kişi benim

Salih Malkoçoğlu Bu kişi benim

Mehmet Ali Özler Bu kişi benim

Mehmet Öztürk Bu kişi benim

Yayımlanma Tarihi 1 Haziran 2017
Yayımlandığı Sayı Yıl 2017 Cilt: 3 Sayı: 1

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