A pilot study on diagnosing laryngopharyngeal reflux disease by pharyngeal pH probe monitoring

Yıl 2013, Cilt: 3 Sayı: 3, 122 - 128, 01.09.2013

Mümtaz Taner Torun Murat Gümüşsoy İbrahim Çukurova İ. Burak Arslan Tolga Kandoğan

https://doi.org/10.2399/jmu.2013003004

Öz

Objective: We aimed to evaluate (laryngopharyngeal reflux) LPR disease group and group with healthy volunteers and compare results obtained using Dx pH probe in the diagnosis of LPR disease. Methods: Fifty-seven LPR patients with typical scores of reflux symptom index (RSI) and reflux finding scoring (RFS) system and 20 healthy volunteers without laryngopharyngeal symptoms and physical examination findings were included in the study after excluding other concomitant diseases. All patients were requested to complete RSI and RFS forms. Healthy volunteers, with RSI 7. Dx pH probes were applied to each group. Fisher's exact test, Shapiro-Wilk test, T test and Mann-Whitney test were used for statistical analysis. A p value

Anahtar Kelimeler

Laryngopharyngeal reflux, reflux symptom index, reflux finding score, pharyngeal pH probe

Larengofarengeal reflü hastalığının tanısında farengeal pH probu ile pilot bir çalışma

Öz

Amaç: Çalışmamızda larengofarengeal reflü (LFR) hastalığı olan ve sağlıklı iki grup değerlendirilerek, Dx pH probunun LPR tanısında sonuçlarını karşılaştırmayı amaçladık. Yöntem: Diğer hastalıklar ekarte edildikten sonra hem reflü semptom indeksi (RSİ) hem de reflü bulgu skoru (RBS) ile tipik skorlara sahip 57 LFR olgusu ile larengofarengeal yakınması ve fizik muayene bulguları olmayan 20 sağlıklı gönüllü çalışmaya alındı. Tüm olgulara RSİ ve RBS formları dolduruldu. RSİ 7 olanlar LFR grubunu oluşturdu. İki gruba Dx pH probu takılarak veriler elde edildi. İstatistiksel değerlendirmede Fisher'in kesin olasılık testi, Shapiro-Wilk testi, T testi ve Mann-Whitney testi kullanıldı. p

Anahtar Kelimeler

Larengofarengeal reflü, reflü semptom indeksi, reflü bulgu skoru, farengeal pH probu

Kaynakça

• Rouev P, Chakarski I, Doskov D, Dimov G, Staykova E. Laryngopharyngeal symptoms and gastroesophageal reflux disease. J Voice 2005;19:476-80.
• Belafsky PC, Postma GN, Koufman JA. Validity and reliability of the reflux symptom index (RSI). J Voice 2002;16:274-7.
• Belafsky PC, Postma GN, Koufman JA. The validity and relia- bilily of the reflux finding score (RFS). Laryngoscope 2001;111: 1313-7.
• Chheda NN, Seybt MW, Schade RR, Postma GN. Normal val- ues for pharyngeal pH monitoring. Ann Otol Rhinol Laryngol 2009;118:166-71.
• Golub JS, Johns MM 3rd, Lim JH, DelGaudio JM, Klein AM. Comparison of an oropharyngeal pH probe and a standard dual pH probe for diagnosis of laryngopharyngeal reflux. Ann Otol Rhinol Laryngol 2009;118:1-5.
• Wiener GJ, Tsukashima R, Kelly C, et al. Oropharyngeal pH monitoring for the detection of liquid and aerosolized suprae- sophageal gastric reflux. J Voice 2009;23:498-504.
• Ayazi S, Lipham JC, Hagen JA, et al. A new technique for meas- urement of pharyngeal ph: normal values and discriminating ph threshold. J Gastrointest Surg 2009;13:1422-9.
• Koufman JA. The otolaryngologic manifestations of gastroe- sophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-hour pH monitoring and an experi- mental investigation of the role of acid and pepsin in the develop- ment of laryngeal injury. Laryngoscope 1991;101(4 Pt 2 Suppl 53):1-78.
• Green WE, Castell JA, Castell DO. Upper esophageal sphincter pressure recording: is an oval manometry catheter necessary? Dysphagia 1988;2:162-5.
• Koufman JA, Amin MR, Panetti M. Prevalence of reflux in 113 consecutive patients with laryngeal and voice disorders. Otolaryngol Head Neck Surg 2000;123:385-8.
• Ossakow SJ, Elta G, Colturi T, Bogdasarian R, Nostrant TT. Esophageal reflux and dysmotility as the basis for persistent cervi- cal symptoms. Ann Otol Laryngol 1987;96:387-92.
• Axford SE, Sharp N, Ross PE, et al. Cell biology of laryngeal epithelial defenses healt and disease: preliminary studies. Ann Otol Laryngol 2001;110:1099-108.
• Koufman JA, Belafsky PC, Bach KK, Daniel E, Postma GN. Prevalence of esophagitis in patients with pH-documented laryn- gopharyngeal reflux. Laryngoscope 2002;112:1606-9.
• Wiener GJ, Koufman JA, Wu WC, Cooper JB, Richter JE, Castell DO. Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitor- ing. Am J Gastroenterol 1989;84:1503-8.
• Yorulmaz ‹. Larengofarengeal reflü. KBB Forum (Ankara) 2002;1: 22-34.
• Little JP, Matthews BL, Glock MS, et al. Extraesophageal pedi- atric reflux: 24-hour double-probe pH monitoring in 222 chil- dren. Ann Otol Rhinol Laryngol Suppl 1997;169:1-16.
• Postma GN, Halum SL. Laryngeal and pharyngeal complications of gastroesophageal reflux disease. GI Motility Online (2006) doi:10.1038/gimo46.
• Naiboglu B, Durmus R, Tek A, Toros SZ, Egeli E. Do the laryn- gopharyngeal symptoms and signs ameliorate by empiric treat- ment in patients with suspected laryngopharyngeal reflux? Auris Nasus Larynx 2011;38:622-7.
• Oelschlager BK, Eubanks TR, Maronian N, et al. Laryngoscopy and pharyngeal pH are complementary in the diagnosis of gas- troesophageal-laryngeal reflux. J Gastrointest Surg 2002;6:189-94.
• Friedman M, Hamilton C, Samuelson CG, et al. The value of rou- tine pH monitoring in the diagnosis and treatment of laryngopha- ryngeal reflux. Otolaryngol Head Neck Surg 2012;146:952-8.
• Cherry J, Margulies SI. Contact ulcer of the larynx. Laryngoscope 1968;78:1937-40.
• Ouatu-Lascar R, Lin OS, Fitzgerald RC, Triadafilopoulos G. Upright versus supine reflux in gastroesophageal reflux disease. J Gastroenterol Hepatol 2001;16:1184-90.
• Freidin N, Mittal RK, McCallum RW. Does body posture affect the incidence and mechanism of gastro-oesophageal reflux? Gut 1991;32:133-6.
• Portale G, Peters J, Hsieh CC, et al. When are reflux episodes symptomatic? Dis Esophagus 2007;20:47-52.
• This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY
• NC-ND0) Licence (http://creativecommons.org/licenses/by-nc-nd/3.0/) which permits unrestricted noncommercial use, distribution, and reproduc
• tion in any medium, provided the original work is properly cited.
• Please cite this article as: Torun MT, Gümüflsoy M, Çukurova ‹, Arslan ‹B, Kando¤an T. A pilot study on diagnosing laryngopharyngeal reflux dis
• ease by pharyngeal pH probe monitoring. J Med Updates 2013;3(3):122-128.