Association of circulating B-type natriuretic peptide with osteoporosis in patients with type 2 diabetes

Abstract

Objective: The aim of this study was to evaluate the relationship of circulating B-type natriuretic peptide (BNP) with osteoporosis in type 2 diabetes mellitus (T2DM) patients. Material and Method: 95 patients with T2DM were included in the study. Patients with circulating BNP levels in their patient file systems and whose BMD were measured within 15 days were included in the study. The patients were divided into three groups according to their BMD scores as normal, osteopenia and osteoporosis. The relationship between circulating BNP and diabetic osteoporosis and other parameters was investigated. Results: A total of 95 patients, 75 female and 20 male, were included in our study. The mean age of the patients was 66.09±5.96 years. Gender, age and BMI were similar between the groups. The duration of DM was found to be significantly higher in the osteoporosis group (p<0.005). In the comparison of laboratory parameters between groups, the averages of glucose, triglyceride, HbA1c, ALP and BNP were statistically significantly higher in the osteoporosis group (p<0.05). Conclusion: Circulating BNP can be used as a biomarker for osteoporosis patients with T2DM.

Keywords

• Type 2 diabetes mellitus
• osteoporosis
• B-type natriuretic peptide

Tip 2 diyabet hastalarında dolaşımdaki B-tipi natriüretik peptidin osteoporoz ile ilişkisi

Abstract

Amaç: Bu çalışmanın amacı tip 2 diabetes mellitus (T2DM) hastalarında dolaşımdaki B-tipi natriüretik peptid (BNP)’in osteoporoz ile ilişkisini değerlendirmektir. Gereç ve Yöntem: T2DM’li 95 hasta çalışmaya dahil edildi. Hasta dosya sistemlerinde dolaşımdaki BNP seviyeleri olan ve 15 gün içerisinde kemik mineral yoğunluğu (KMY) bakılmış hastalar çalışmaya dahil edildi. Hastalar KMY skorlarına göre normal, osteopeni ve osteoporoz olarak üç gruba ayrıldı. Dolaşımdaki BNP ile diyabetik osteoporoz ve diğer parametreler arasındaki ilişki incelendi. Bulgular: Çalışmamıza 75’i kadın, 20’si erkek olmak üzere toplam 95 hasta dahil edildi. Hastaların yaş ortalaması 66,09±5,96 idi. Gruplar arasında cinsiyet, yaş ve vücut kitle indeksi (VKİ) benzer bulundu. DM süresi osteoporoz grubunda anlamlı olarak yüksek saptandı (p<0,005). Laboratuvar paramaretlerinin gruplar arası karşılaştırılmasında glukoz, trigliserid, glikolize hemoglobin (HbA1c), alkalen fosfataz (ALP) ve BNP ortalamaları istatistiksel olarak anlamlı şekilde osteoporoz grubunda daha yüksekti (p<0,05). Sonuç: Dolaşımdaki BNP, T2DM’li osteoporoz hastaları için bir biyobelirteç olarak kullanılabilir.

Keywords

• Tip 2 diabetes mellitus
• osteoporoz
• B-tipi natriüretik peptid

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