The relationship between the prognostic nutritional index and the clinical course of COVID-19: a single-center experience

Abstract

Aim: It was aimed to investigate the relationship between the prognostic nutritional index (PNI) and the clinical course in COVID-19 because the nutritional status is important in defense against infection. Material and Method: 1579 patients who applied to the hospital inpatient clinic between 01/04/2020 and 30/11/2020 were included in the study. The PNI scores of the patients were calculated at the time of admission to the hospital. Comparisons were made between PNI scores of the patients and intensive care unit admission status, treatment results, length of hospital stay, and presence of pneumonia on thorax CT. Moreover, comparisons were made between PNI scores and C-reactive protein (CRP), neutrophil/ymphocyte ratio (NLR), CRP/albumin ratio. Results: A total of 1579 patients (755 females and 824 males) were included in the study. The rate of admission to the ICU was significantly higher in males. The mortality rate of the study group was 9.4%. PNI scores were found to be significantly lower in patients who died and in patients admitted to the ICU. CRP and CRP/albumin ratio levels were significantly higher in patients with pneumonia on thorax CT, in patients admitted to the intensive care unit, and in patients who died. There were a significant negative correlation between PNI score and CRP/albumin ratio levels. Conclusion: PNI scores were found to be significantly lower in patients who needed admission to the intensive care unit and died due to severe COVID-19 than the others. In patients with a low PNI score, COVID-19 can be more severe and it may cause worse clinical outcomes.

Keywords

• COVID-19
• CRP/albumin ratio
• neutrophil/lymphocyte ratio
• prognostic nutritional index

Prognostik nütrisyonel indeks ve COVID-19 klinik seyri arasındaki ilişki: tek merkez deneyimi

Abstract

Amaç: Enfeksiyona karşı savunmada beslenme durumunun önemli olması nedeniyle COVID-19’da prognostik beslenme indeksi (PNI) ile klinik seyir arasındaki ilişkinin araştırılması amaçlandı. Gereç ve Yöntem: 01/04/2020-30/11/2020 tarihleri arasında hastaneye başvuran 1579 hasta çalışmaya dahil edildi. Hastaların hastaneye başvuru anında PNI skorları hesaplandı. Hastaların PNI skorları ile yoğun bakıma yatış durumu, tedavi sonuçları, hastanede kalış süreleri ve toraks BT’de pnömoni varlığı arasında karşılaştırmalar yapıldı. Ayrıca PNI skorları ile C-reaktif protein (CRP), nötrofil/imfosit oranı (NLR), CRP/albumin oranı arasında karşılaştırmalar yapıldı. Bulgular: Çalışmaya toplam 1579 hasta (755 kadın ve 824 erkek) dahil edildi. Erkeklerde yoğun bakıma kabul oranı anlamlı olarak daha yüksekti. Çalışma grubunun mortalite oranı %9,4’tü. Ölen hastalarda ve yoğun bakım ünitesine kabul edilen hastalarda PNI skorları anlamlı olarak daha düşük bulundu. Toraks BT’sinde pnömoni olan hastalarda, yoğun bakıma yatırılan hastalarda ve ölen hastalarda CRP ve CRP/albümin oranı anlamlı olarak daha yüksekti. PNI skoru ile CRP/albümin oranı arasında anlamlı negatif korelasyon vardı. Sonuç: Şiddetli COVID-19 nedeniyle yoğun bakım ünitesine yatırılması gereken ve ölen hastalarda PNI skorları anlamlı derecede daha düşük bulundu. PNI skoru düşük olan hastalarda COVID-19 daha şiddetli seyredebilir ve daha kötü klinik sonuçlara neden olabilir.

Keywords

• COVID-19
• CRP/albümin oranı
• nötrofil/lenfosit oranı
• prognostik beslenme indeksi

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