Short and long-term safety and durability of PEG-J tube in jejunal levodopa infusion in patients with Parkinson's disease

Abstract

Aims: To investigate PEG-J related adverse events and tube durability in patients with Parkinson’s disease who underwent PEG-J procedure for jejunal drug infusion. Methods: PEG-J implanted patients, who were planned jejunal levodopa infusion, were included in the study. The demographic characteristics of the patients, tube durability, tube replacement, reason for tube replacement, number of procedures, and adverse events related to procedures were retrospectively analyzed. Results: Thirty-four patients with a mean age of 65.7±9.8 years included in the study. The mean total PEG-J follow-up period of the patients was 33.6±21.1 months. Functions of PEG-J tubes were preserved in 82.5% at 6 months, 78.4% at 12 months, and 65.2% at 18 months. Twenty-one (% 61,8) patients required at least one PEG-J replacement. Of the PEG-J replacements, 90.4% were due to device-related advers events. A total of 29 procedure or stoma related adverse events occurred in 21 (61.8%) patients, and a total of 28 PEG-J tube related adverse events occurred in 19 (55.9%) patients. A total of 6 (17.5%) early procedure-related adverse events (acute abdomen and peritonitis, prolonged bleeding, stoma leakage, stoma infection) were observed, all occurring in the first 7 days. Twenty-three (67.6%) stoma-related late adverse events (stoma leakage, stoma infection, abscess) were detected. Two patients who developed peritonitis were successfully treated with conservative treatments. Conclusion: PEG-J used for drug application is a safe method and can be used for a long time without the need for frequent replacement. Most of advers events can be managed with conservative treatments.

Keywords

• PEG-J
• advers events
• Parkinson's disease
• jejunal drug infusion

Jejunal levodopa infüzyonu alan Parkinson hastalarında PEG-J tüpünün kısa ve uzun dönem güvenilirliği ve devamlılığı

Abstract

Amaç: Jejunal ilaç infüzyonu için PEG-J prosedürü uygulanan Parkinson hastalarında PEG-J ile ilişkili advers olayları ve tüp devamlılığını araştırmak. Gereç ve Yöntem: Çalışmaya jejunal Levodopa infüzyonu planlanan PEG-J tüpü takılmış hastalar dahil edildi. Hastaların demografik özellikleri, tüp devamlılığı, tüp değişimi, tüp değiştirme nedeni, işlem sayısı ve işleme bağlı advers olaylar retrospektif olarak incelendi. Bulgular: Çalışmaya yaş ortalaması 65.7±9.8 olan 34 hasta dahil edildi. Hastaların ortalama toplam PEG-J takip süresi 33.6±21.1 aydı. PEG-J tüplerinin fonksiyonları 6. ayda %82.5, 12. ayda %78.4 ve 18. ayda %65.2 oranında korunmuştu. Yirmi bir (% 61.8) hastada en az bir PEG-J replasmanı gerekti. PEG-J değişimlerinin %90.4'ü cihazla ilgili nedenlerden kaynaklanıyordu. Yirmi bir (%61.8) hastada prosedür veya stoma ile ilgili toplam 29 advers olay meydana geldi ve 19 (%55.9) hastada PEG-J tüpü ile ilgili toplam 28 advers olay meydana geldi. İşlemle ilgili toplam 6 (%17.5) erken advers olay (akut karın ve peritonit, uzamış kanama, stoma kaçağı, stoma enfeksiyonu) gözlendi ve tümü ilk 7 gün içinde meydana geldi. Yirmi üç (%67.6) stomaya bağlı geç advers olay (stoma kaçağı, stoma enfeksiyonu, apse) tespit edildi. Peritonit gelişen iki hasta konservatif tedavilerle başarıyla tedavi edildi. Sonuç: İlaç uygulaması için kullanılan PEG-J güvenli bir yöntemdir ve sık tüp değiştirilmesi gerekmeden uzun süre kullanılabilir. Advers olayların çoğu konservatif yöntemlerle tedavi edilebilir. Anahtar kelimeler: PEG-J, advers olaylar, Parkinson hastalığı, jejunal ilaç infüzyonu

Keywords

• PEG-J
• Advers olaylar
• Parkinson Hastalığı
• jejunal ilaç infüzyonu

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