The role of the systemic inflammatory response index in the prediction of chronic total occlusion: useful or not?

Yıl 2023, , 542 - 546, 27.10.2023

Gökhan Ergün , Yasemin Doğan

https://doi.org/10.47582/jompac.1349803

Öz

Aim: Inflammation is very important in the pathogenesis of atherosclerosis and CAD. Chronic total occlusion (CTO) is a chronic form of CAD and is common in patients with severe CAD. The aim of this study was to determine the association of the systemic inflammatory response index (SIRI), a marker of inflammation, with CTO.

Materials and Methods: Our study was retrospective and included 100 CAD patients with CTO and 100 CAD patients without CTO. SIRI was compared between the two groups.

Results: Among the basic clinical and laboratory characteristics of the patients, age, white blood cell, and neutrophil counts were statistically higher in the CTO group (p=0.044, p=0.044, p=0.036, respectively). SIRI parameters were similar between the groups, and no statistical difference was observed (p=0.111). According to the ROC analysis, the optimum cut-off value for SIRI was >1040 (sensitivity 70.0% and specificity 44.0%).

Conclusion: SIRI is not a useful predictor for the detection of CTO.

Anahtar Kelimeler

Systemic inflammatory response index, chronic total occlusion, coronary artery disease

Sistemik inflamatuar yanıt indeksin(SIRI) kronik total oklüzyon öngörülmesinde rolü: yararlı mı değil mi?

Öz

ÖZET
Amaç: Ateroskleroz ve KAH patojeninizde inflamasyon oldukça önemlidir. Kronik total oklüzyon (KTO) KAH’ın kronik bir formudur ve ciddi KAH olanlarda sık görülür. Bu çalışmanın amacı inflamasyon göstergelerinden biri olan sistemik inflamatuar yanıt indeksin (SIRI) KTO ile olan ilişkisini ortaya koymaktır.
Gereç ve Yöntem: Çalışmamız retrospektif olup 100 adet KTO’u olan ve 100 adet KTO’u olmayan KAH hastası çalışmaya dahil edildi. 2 grup arasında SIRI karşılaştırıldı.
Bulgular: Hastaların temel klinik ve laboratuvar özellikleri arasında yaş, beyaz kan hücresi ve nötrofil sayısı KTO su olan grupta istatiksel olarak daha yüksek saptandı. (Sırası ile p=0,044, p=0,044, p=0,036). Gruplar arasında SIRI parametreleri benzer olarak saptanmış olup istatiksel farklılık izlenmedi. (p=0,111). Yapılan ROC analizine göre SIRI için optimum cut-off değeri >1040 (sensitivite %70.0 ve spesifite %44.0) olarak elde edilmiştir.
Sonuç: SIRI KTO saptanmasında kullanışlı bir prediktör değildir.

Anahtar Kelimeler

Sistemik inflamatuar yanıt indeks, kronik total oklüzyon, koroner arter hastalığı

Kaynakça

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