Genç erişkin hastalarda koroner arter aterosklerozunu öngörmede kardiyotorasik oranın rolü

Abstract

Amaç: Bu çalışmada, genç erişkin hastalarda koroner atherosklerozu tahmin etmede kardiyotorasik oranın rolünün belirlenmesi amaçlanmıştır. Hastalar ve Yöntemler: Bu tek merkezli retrospektif çalışmada Ekim 2022-Mayıs 2024 tarihleri arasında koroner arter hastalığı şüphesi ile koroner bilgisayarlı tomografi anjiyografi (CTA) çekimi yapılan genç erişkin hasta dâhil edilmiştir. Tüm hastaların demografik ve klinik özgeçmişleri tıbbı kayıt sisteminden belirlendi. Söz konusu hastaların koroner arter kalsiyum skorları (CACSc) ve kardiyotorasik oranları (CTR) koroner CTA görüntüleri üzerinden hesaplanıp kayıt altına alındı. Bulgular: Bu çalışmaya, yaş ortalaması 42,2±3,1 yıl olan 45 yaş altı toplam 264 genç erişkin hasta dahil edildi. Çalışmaya dahil edilen hastalar coroner CTA’da aterosklerotik kalsifik plak varlığına göre iki gruba ayrıldı. Sigara kullanım öyküsü, hyperlipidemia, hipertansiyon ve diabetes mellitus öyküsü iki hasta grubunda anlamlı derecede farklıydı (hepsi için, p<0.05). Tek değişkenli regrasyon analizde hyperlipidemia, diabetes mellitus, hipertansiyon, sigara kullanım öyküsü ve yüksek CTR değerleri koroner aterosklerotik kalsifik plak için risk faktörleri olarak belirlendi. Çok değişkenli regresyon analizde ise sigara kullanım öyküsü (p=0.001, OR: 1.55; 95% confidence interval (CI), 0.819-2.93) ve 0.5150 üstündeki CTR değerleri (p <0.001, OR: 45.8; 95% confidence interval (CI), 14.5-144.4) koroner aterosklerotik kalsifik plak ile bağımsız olarak ilişkili oldukları belirlendi. Sonuç: Bulgularımız, CTR değerleri 0.5150 üzerinde olan genç yetişkin hastalarda koroner atheroskleroz riskinin yüksek olduğunu göstermektedir.

Keywords

• Kardiyotorasik Oran
• Koroner Arter Kalsiyum Skoru
• Aterosklerotik Plak
• Koroner Bilgisayarlı Tomografi Anjiyografi

The role of cardiothoracic ratio in predicting coronary artery atherosclerosis in young adult patients

Abstract

Aims: This study aimed to determine the role of cardiothoracic ratio in predicting coronary atherosclerosis in young adult patients. Methods: In this single-center retrospective study, young adult patients who underwent coronary computed tomography angiography (CTA) with suspicion of coronary artery disease between October 2022 and May 2024 were included. Demographic and clinical histories of all patients were determined from the medical record system. Coronary artery calcium scores (CACSc) and cardiothoracic ratios (CTR) of the patients in question were calculated and recorded from the coronary CTA images. Result: A total of 264 young adult patients under the age of 45, with an average age of 42.2±3.1 years, were included in this study. The patients included in the study were divided into two groups according to the presence of atherosclerotic calcific plaque in coronary CTA. Smoking history, hyperlipidemia, hypertension and diabetes mellitus history were significantly different in the two patient groups (for all, p<0.05). In univariate regression analysis, hyperlipidemia, diabetes mellitus, hypertension, smoking history and high CTR values were determined as risk factors for coronary atherosclerotic calcific plaque. Conclusion: Our findings show that the risk of coronary atherosclerosis is high in young adult patients with CTR values above 0.5150.

Keywords

• Cardiothoracic ratio
• Coronary Artery Calcium Score
• Atherosclerotic Plaque
• Coronary Computed Tomography Angiography

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