The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients

Neçirvan Çağdaş Çaltek; Mahmut Yassa; Gözde Şahin; Başak Özge Kayan; İlteriş Yaman; İlkbal Temel

The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients

Abstract

Aims: To evaluate the diagnostic and therapeutic role of colposcopy in patients with negative cervical cytology but positive for high-risk human papillomavirus (hrHPV) types other than HPV 16 and 18, in light of current guideline recommendations. Methods: This retrospective study included 428 women aged 21-65 who underwent colposcopy at a tertiary care center between June 2020 and December 2024. All patients had negative cytology and tested positive exclusively for high-risk HPV types other than HPV 16/18. Cervical biopsy and endocervical curettage (ECC) were performed during colposcopy. Histopathological evaluations were conducted by experienced gynecologic pathologists using the Lower Anogenital Squamous Terminology (LAST) system. Demographic and clinical data were recorded and analyzed using SPSS version 27. Results: Among the 428 patients, 281 (65.7%) had no dysplasia, 126 (29.4%) had CIN 1, 15 (3.5%) had CIN 2, and 6 (1.4%) had CIN 3. No cases of invasive cervical cancer were detected. ECC results showed CIN 1 lesions in 11 patients (2.6%) and no high-grade lesions. The overall rate of CIN2+ lesions was 4.9%. Most patients with CIN2+ lesions were multiparous, premenopausal, and had a mean age of 40 years. Conclusion: Current ASCCP guidelines recommend follow-up with co-testing after one year for patients with negative cytology and non-16/18 hrHPV positivity. However, the 4.9% rate of CIN2+ lesions observed in this study suggests that immediate colposcopy may be clinically beneficial in this patient group. Especially in populations with low adherence to follow-up, colposcopy may represent an alternative management approach.

Keywords

Supporting Institution

This research received no external funding.

Ethical Statement

This study was approved by the Ethics Committee of Başakşehir Çam and Sakura City Hospital (Approval No: E-96317027-514.10-263703353). According to Turkish legislation and the institutional ethics committee policies of our hospital, informed consent is not required for retrospective studies.

Thanks

We offer our sincere gratitude to all our colleagues who supported and contributed to this study.

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Details

Primary Language

English

Subjects

Gynecologic Oncology Surgery

Journal Section

Research Article

Authors

Neçirvan Çağdaş Çaltek ^*
0000-0002-2823-8630
Türkiye

Mahmut Yassa
0000-0002-1176-7608
Türkiye

Gözde Şahin
0000-0003-3067-9125
Türkiye

Başak Özge Kayan
0000-0003-0699-0482
Türkiye

İlteriş Yaman
0000-0002-5563-2887
Türkiye

İlkbal Temel
0000-0002-7337-9977
Türkiye

Publication Date

June 25, 2026

Submission Date

March 12, 2026

Acceptance Date

May 19, 2026

Published in Issue

Year 2026 Volume: 7 Number: 3

IZ

https://izlik.org/JA82CR72NM

Cite

RIS / Bibtex

APA

Çaltek, N. Ç., Yassa, M., Şahin, G., Kayan, B. Ö., Yaman, İ., & Temel, İ. (2026). The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients. Journal of Medicine and Palliative Care, 7(3), 504-508. https://izlik.org/JA82CR72NM

AMA

1.Çaltek NÇ, Yassa M, Şahin G, Kayan BÖ, Yaman İ, Temel İ. The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients. J Med Palliat Care / JOMPAC / jompac. 2026;7(3):504-508. https://izlik.org/JA82CR72NM

Chicago

Çaltek, Neçirvan Çağdaş, Mahmut Yassa, Gözde Şahin, Başak Özge Kayan, İlteriş Yaman, and İlkbal Temel. 2026. “The Role of Colposcopy in the Clinical Diagnosis and Management of Cytology-Negative, Non-16 18 High-Risk HPV Positive Patients”. Journal of Medicine and Palliative Care 7 (3): 504-8. https://izlik.org/JA82CR72NM.

EndNote

Çaltek NÇ, Yassa M, Şahin G, Kayan BÖ, Yaman İ, Temel İ (June 1, 2026) The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients. Journal of Medicine and Palliative Care 7 3 504–508.

IEEE

[1]N. Ç. Çaltek, M. Yassa, G. Şahin, B. Ö. Kayan, İ. Yaman, and İ. Temel, “The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 3, pp. 504–508, June 2026, [Online]. Available: https://izlik.org/JA82CR72NM

ISNAD

Çaltek, Neçirvan Çağdaş - Yassa, Mahmut - Şahin, Gözde - Kayan, Başak Özge - Yaman, İlteriş - Temel, İlkbal. “The Role of Colposcopy in the Clinical Diagnosis and Management of Cytology-Negative, Non-16 18 High-Risk HPV Positive Patients”. Journal of Medicine and Palliative Care 7/3 (June 1, 2026): 504-508. https://izlik.org/JA82CR72NM.

JAMA

1.Çaltek NÇ, Yassa M, Şahin G, Kayan BÖ, Yaman İ, Temel İ. The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients. J Med Palliat Care / JOMPAC / jompac. 2026;7:504–508.

MLA

Çaltek, Neçirvan Çağdaş, et al. “The Role of Colposcopy in the Clinical Diagnosis and Management of Cytology-Negative, Non-16 18 High-Risk HPV Positive Patients”. Journal of Medicine and Palliative Care, vol. 7, no. 3, June 2026, pp. 504-8, https://izlik.org/JA82CR72NM.

Vancouver

1.Neçirvan Çağdaş Çaltek, Mahmut Yassa, Gözde Şahin, Başak Özge Kayan, İlteriş Yaman, İlkbal Temel. The role of colposcopy in the clinical diagnosis and management of cytology-negative, non-16/18 high-risk HPV positive patients. J Med Palliat Care / JOMPAC / jompac [Internet]. 2026 Jun. 1;7(3):504-8. Available from: https://izlik.org/JA82CR72NM