Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study
Abstract
Aims: To investigate the association between systemic hypertension and vitreous humor attenuation on computed tomography (CT), and to evaluate its relationship with age, gender, and ocular morphometric parameters.
Methods: This retrospective comparative study included 132 participants (66 hypertensive patients and 66 age- and sex-matched controls) who underwent cranial CT between January 2023 and March 2026. Vitreous attenuation values were measured using region-of-interest (ROI) analysis, and ocular globe dimensions (anteroposterior and transverse diameters) were assessed on axial images. Statistical analyses were performed using non-parametric tests, and correlations were evaluated with Spearman’s coefficient. Univariate and multivariate logistic regression analyses were used to assess factors associated with hypertension.
Results: Vitreous attenuation values were significantly higher in the hypertensive group compared to controls (mean: 12.44±2.3 vs. 11.16±1.8 Hounsfield Units, p=0.004). No significant differences were observed in ocular globe dimensions between groups (p>0.05). A significant positive correlation was found between age and vitreous attenuation in both hypertensive (r=0.332, p=0.006) and control groups (r=0.411, p=0.001), while no association was identified between age and globe dimensions. No sex-related differences were detected. In multivariate analysis, mean vitreous attenuation remained significantly associated with hypertension (OR=1.333, 95% CI: 1.101-1.614, p=0.003). Additionally, mean anteroposterior (AP) diameter demonstrated a significant inverse association with hypertension in the multivariable model (OR=0.421, 95% CI: 0.181-0.976, p=0.044).
Conclusion: Systemic hypertension is associated with increased vitreous attenuation on CT, suggesting subtle microstructural alterations. These findings suggest a possible relationship between systemic hypertension and vitreous attenuation.
Keywords
Supporting Institution
The authors received no financial support for the conduct or publication of this research.
Ethical Statement
The study was initiated with the approval of the Gaziantep City Hospital Clinical Researches Ethics Committee (Decision No: 534/2026).
Thanks
None
References
- El-Maghrabi SMMM, Ghazawy RMFE, Dayem HMKA, Swelem AHAM, Saif PS. Evaluating the effect of systemic hypertension on retinal, optic nerve head microvasculature and field of vision using optical coherence tomography angiography and visual field analyzer. BMC Ophthalmol. 2026;26(1):42. doi:10.1186/s12886-025-04460-7
- Bhargava M, Ikram M, Wong TY. How does hypertension affect your eyes? J Human Hypertension. 2012;26(2):71-83. doi:10.1038/jhh.2011.37
- Mayor M, Camafort M, Estruch R. Retinal microvasculature assessment: useful to refine cardiovascular risk. Eur Heart J. 2024;45(33):3086-3088. doi:10.1093/eurheartj/ehae422
- 4. Tan W, Yao X, Le T-T, et al. The application of optical coherence tomography angiography in systemic hypertension: a meta-analysis. Front Med. 2021;8:778330. doi:10.3389/fmed.2021.778330
- Angi M, Kalirai H, Coupland SE, Damato BE, Semeraro F, Romano MR. Proteomic analyses of the vitreous humour. Mediators Inflamm. 2012; 2012(1):148039. doi:10.1155/2012/148039
- Mishra D, Gade S, Glover K, Sheshala R, Singh TRR. Vitreous humor: composition, characteristics and implication on intravitreal drug delivery. Curr Eye Res. 2023;48(2):208-218. doi:10.1080/02713683.2022.2119254
- Murthy KR, Goel R, Subbannayya Y, et al. Proteomic analysis of human vitreous humor. Clin Proteomics. 2014;11(1):29. doi:10.1186/1559-0275-11-29
- Aydin E, Çakir İM, Kiliç Ş, Gürün E, Öztürk M. Evaluation of vitreous humor changes in patients with diabetic retinopathy using computed tomography. Gümüshane Üniv Saglik Bilim Derg. 2025;14(3):1227. doi:10.37989/gumussagbil.1730131
Details
Primary Language
English
Subjects
Radiology and Organ Imaging
Journal Section
Research Article
Publication Date
August 15, 2026
Submission Date
May 5, 2026
Acceptance Date
July 2, 2026
Published in Issue
Year 2026 Volume: 7 Number: 4
APA
Çapkan, D. Ü., Kaplan, M., Gözen, İ., & Şahan, M. H. (2026). Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study. Journal of Medicine and Palliative Care, 7(4), 682-687. https://izlik.org/JA99MB88AM
AMA
1.Çapkan DÜ, Kaplan M, Gözen İ, Şahan MH. Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study. J Med Palliat Care / JOMPAC / jompac. 2026;7(4):682-687. https://izlik.org/JA99MB88AM
Chicago
Çapkan, Davut Ünsal, Mehmet Kaplan, İbrahim Gözen, and Mehmet Hamdi Şahan. 2026. “Vitreous Humor Attenuation on Computed Tomography and Its Association With Hypertension: A Retrospective Comparative Study”. Journal of Medicine and Palliative Care 7 (4): 682-87. https://izlik.org/JA99MB88AM.
EndNote
Çapkan DÜ, Kaplan M, Gözen İ, Şahan MH (August 1, 2026) Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study. Journal of Medicine and Palliative Care 7 4 682–687.
IEEE
[1]D. Ü. Çapkan, M. Kaplan, İ. Gözen, and M. H. Şahan, “Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study”, J Med Palliat Care / JOMPAC / jompac, vol. 7, no. 4, pp. 682–687, Aug. 2026, [Online]. Available: https://izlik.org/JA99MB88AM
ISNAD
Çapkan, Davut Ünsal - Kaplan, Mehmet - Gözen, İbrahim - Şahan, Mehmet Hamdi. “Vitreous Humor Attenuation on Computed Tomography and Its Association With Hypertension: A Retrospective Comparative Study”. Journal of Medicine and Palliative Care 7/4 (August 1, 2026): 682-687. https://izlik.org/JA99MB88AM.
JAMA
1.Çapkan DÜ, Kaplan M, Gözen İ, Şahan MH. Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study. J Med Palliat Care / JOMPAC / jompac. 2026;7:682–687.
MLA
Çapkan, Davut Ünsal, et al. “Vitreous Humor Attenuation on Computed Tomography and Its Association With Hypertension: A Retrospective Comparative Study”. Journal of Medicine and Palliative Care, vol. 7, no. 4, Aug. 2026, pp. 682-7, https://izlik.org/JA99MB88AM.
Vancouver
1.Davut Ünsal Çapkan, Mehmet Kaplan, İbrahim Gözen, Mehmet Hamdi Şahan. Vitreous humor attenuation on computed tomography and its association with hypertension: a retrospective comparative study. J Med Palliat Care / JOMPAC / jompac [Internet]. 2026 Aug. 1;7(4):682-7. Available from: https://izlik.org/JA99MB88AM
